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1.发明申请公开(公告)号：US20130224258A1
公开(公告)日：2013-08-29
申请号：US13765514
申请日：2013-02-12
CPC分类号： A01N55/02 , A01N25/08 , A01N37/18 , A01N43/16 , A01N43/36 , A01N43/40 , A01N43/54 , A01N43/60 , A01N43/78 , A01N43/84 , A01N43/90 , A01N45/00 , A01N47/44 , A01N57/24 , A61K9/0014 , A61K9/06 , A61K9/10 , A61K9/16 , A61K9/7023 , A61K31/407 , A61K31/427 , A61K31/431 , A61K31/44 , A61K31/4409 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K31/546 , A61K31/555 , A61K31/65 , A61K31/665 , A61K31/7028 , A61K31/7036 , A61K31/7048 , A61K38/12 , A61K38/14 , A61L24/0015 , A61L24/0031 , A61L24/06 , A61L2300/404 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating natural and artificial surfaces that contain bacterial biofilm, including unexpected synergy or enhancing effects between bismuth-thiol (BT) compounds and certain antibiotics, to provide formulations including antiseptic formulations. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating certain gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating certain gram-negative bacterial infections.
摘要翻译： 描述了包含新型均相微粒悬浮液的组合物和方法，用于处理含有细菌生物膜的天然和人造表面，包括铋 - 硫醇（BT）化合物和某些抗生素之间的意外协同作用或增强作用，以提供包括防腐剂配方的制剂。 还描述了所公开的BT化合物和BT化合物 - 抗生素组合的以前不可预测的抗菌性质和抗生物膜性质，包括某些此类组合物用于治疗某些革兰氏阳性细菌感染的优先功效，以及某些此类组合物的明显优势 治疗某些革兰氏阴性细菌感染。
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公开(公告)号：US10960012B2
公开(公告)日：2021-03-30
申请号：US16284723
申请日：2019-02-25
IPC分类号： A61K31/555 , A61K9/06 , A61K9/10 , A61K9/70 , A61K31/095 , A61K31/29 , A61K33/245 , A61K9/00 , A61K31/28 , A61K45/06 , A61K9/16 , A61K31/496 , A61K31/545 , A61K31/546 , A61K31/65 , A61K31/7004 , A61K31/7036 , A61K38/14
摘要： Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating natural surfaces that contain bacterial biofilm, including unexpected synergy or enhancing effects between bismuth-thiol (BT) compounds and certain antibiotics, to provide formulations including antiseptic formulations. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating certain gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating certain gram-negative bacterial infections.
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3.发明申请BISMUTH-THIOLS AS ANTISEPTICS FOR EPITHELIAL TISSUES, ACUTE AND CHRONIC WOUNDS, BACTERIAL BIOFILMS AND OTHER INDICATIONS 审中-公开BISMUTH-THIOLS作为上皮组织，急性和慢性创伤，细菌生物和其他适应症的抗生素公开(公告)号：US20130171210A1
公开(公告)日：2013-07-04
申请号：US13782963
申请日：2013-03-01
IPC分类号： A61K31/29 , A61K31/7036 , A61K31/704 , A61K31/496 , A61K38/14 , A61K31/65 , A61K31/426 , A61K31/165 , A61K45/06 , A61K31/7042
CPC分类号： A61K31/29 , A61K9/0014 , A61K9/145 , A61K31/095 , A61K31/165 , A61K31/426 , A61K31/496 , A61K31/65 , A61K31/7036 , A61K31/704 , A61K31/7042 , A61K33/245 , A61K38/14 , A61K45/06 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , A61K2300/00
摘要： Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating acute wounds, chronic wounds and/or a wound or epithelial tissue surface that contains bacterial biofilm, including unexpected synergy between bismuth-thiol (BT) compounds and certain antibiotics, to provide topical formulations including antiseptic formulations, for management and promotion of wound healing and in particular infected wounds. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating gram-negative bacterial infections.
摘要翻译： 描述了包含新颖的均匀微粒悬浮液的组合物和方法，用于治疗急性伤口，慢性伤口和/或包含细菌生物膜的伤口或上皮组织表面，包括铋 - 硫醇（BT）化合物与某些抗生素之间的意外协同作用，以提供 用于治疗和促进伤口愈合，特别是感染伤口的局部制剂，包括防腐剂。 还描述了所公开的BT化合物和BT化合物 - 抗 - 抗生素组合的以前未预知的抗细菌性质和抗生物膜性质，包括某些此类组合物用于治疗革兰氏阳性细菌感染的优先功效，以及某些此类组合物治疗的明显优势 革兰氏阴性细菌感染。
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公开(公告)号：US11974978B2
公开(公告)日：2024-05-07
申请号：US17713893
申请日：2022-04-05
摘要： The invention relates to bismuth-thiol compounds and pharmaceutical preparations thereof. The invention further relates to methods for treating a topical wound, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a bismuth-thiol compound, wherein the composition is applied to the infection. Methods for treating microbial infections such as diabetic foot infections are also provided.
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公开(公告)号：US11564903B2
公开(公告)日：2023-01-31
申请号：US17063491
申请日：2020-10-05
IPC分类号： A61K31/29 , A61K9/00 , A61K31/095 , A61K33/245 , A61K9/14 , A61K31/165 , A61K31/426 , A61K31/496 , A61K31/65 , A61K31/7036 , A61K31/704 , A61K31/7042 , A61K38/14 , A61K45/06
摘要： Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating acute wounds, chronic wounds and/or a wound or epithelial tissue surface that contains bacterial biofilm, including unexpected synergy between bismuth-thiol (BT) compounds and certain antibiotics, to provide topical formulations including antiseptic formulations, for management and promotion of wound healing and in particular infected wounds. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating gram-negative bacterial infections.
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公开(公告)号：US11464749B2
公开(公告)日：2022-10-11
申请号：US16528145
申请日：2019-07-31
IPC分类号： A61K31/095 , A61P31/04 , A61K9/00
摘要： The invention relates to Bis-thiol compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating, managing or lessening the severity of pulmonary infections in a subject, the method comprising administering to the subject a bismuth-thiol (BT) composition that comprises at least one BT compound.
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公开(公告)号：US11207288B2
公开(公告)日：2021-12-28
申请号：US16528097
申请日：2019-10-15
摘要： The invention relates to bismuth-thiol compounds and pharmaceutical preparations thereof. The invention further relates to methods for treating a topical wound, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a bismuth-thiol compound, wherein the composition is applied to the infection. Methods for treating microbial infections such as diabetic foot infections are also provided.
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公开(公告)号：US12036200B2
公开(公告)日：2024-07-16
申请号：US18137521
申请日：2023-04-21
摘要： The invention relates to bismuth-thiol compounds and pharmaceutical preparations thereof. The invention further relates to methods for treating a topical wound, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a bismuth-thiol compound, wherein the composition is applied to the infection. Methods for treating microbial infections such as diabetic foot infections are also provided.
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公开(公告)号：US11324715B2
公开(公告)日：2022-05-10
申请号：US17526535
申请日：2021-11-15
摘要： The invention relates to bismuth-thiol compounds and pharmaceutical preparations thereof. The invention further relates to methods for treating a topical wound, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a bismuth-thiol compound, wherein the composition is applied to the infection. Methods for treating microbial infections such as diabetic foot infections are also provided.
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公开(公告)号：US20170150724A1
公开(公告)日：2017-06-01
申请号：US15199554
申请日：2016-06-30
IPC分类号： A01N55/02 , A61L24/00 , A61L24/06 , A61K31/555 , A01N43/16 , A61K38/14 , A01N43/60 , A01N43/36 , A01N45/00 , A01N43/40 , A61K31/431 , A61K31/546 , A61K31/407 , A01N43/78 , A61K31/7036 , A61K31/496 , A61K31/5383 , A61K31/7048 , A01N43/84 , A01N57/24 , A01N43/54 , A61K31/4409 , A61K38/12 , A61K31/665 , A61K31/5377 , A61K31/427 , A61K31/44 , A61K31/65 , A61K31/7028 , A61K9/16 , A01N25/08 , A01N43/90
CPC分类号： A01N55/02 , A01N25/08 , A01N37/18 , A01N43/16 , A01N43/36 , A01N43/40 , A01N43/54 , A01N43/60 , A01N43/78 , A01N43/84 , A01N43/90 , A01N45/00 , A01N47/44 , A01N57/24 , A61K9/0014 , A61K9/06 , A61K9/10 , A61K9/16 , A61K9/7023 , A61K31/407 , A61K31/427 , A61K31/431 , A61K31/44 , A61K31/4409 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K31/546 , A61K31/555 , A61K31/65 , A61K31/665 , A61K31/7028 , A61K31/7036 , A61K31/7048 , A61K38/12 , A61K38/14 , A61L24/0015 , A61L24/0031 , A61L24/06 , A61L2300/404 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating natural and artificial surfaces that contain bacterial biofilm, including unexpected synergy or enhancing effects between bismuth-thiol (BT) compounds and certain antibiotics, to provide formulations including antiseptic formulations. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating certain gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating certain gram-negative bacterial infections.
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