公开(公告)号：US20120172384A1

公开(公告)日：2012-07-05

申请号：US13379028

申请日：2010-06-17

申请人： Mihiro Sunose ,  Jeremy Major ,  Richard John Harrison ,  Jay Freeman ,  Adeline Morel

发明人： Mihiro Sunose ,  Jeremy Major ,  Richard John Harrison ,  Jay Freeman ,  Adeline Morel

IPC分类号： A61K31/506 ,  A61P37/08 ,  A61P29/00 ,  C07D401/12 ,  A61P37/00

CPC分类号： C07D403/12 ,  C07D413/12

摘要： The invention relates to compounds of formula (I) wherein R1 to R6 and T0 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of ZAP-70, Syk or JAK3 for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

摘要翻译： 本发明涉及式（I）化合物，其中R1至R6和T0具有在说明书和权利要求书中引用的含义。 所述化合物可用作ZAP-70，Syk或JAK3的抑制剂，用于治疗或预防免疫学，炎症，自身免疫，过敏性疾病，免疫介导的疾病。 本发明还涉及包含所述化合物的药物组合物，这些化合物的制备以及作为药物的用途。

公开(公告)号：US20120142667A1

公开(公告)日：2012-06-07

申请号：US13377550

申请日：2010-06-10

申请人： Nigel Ramsden ,  Jeremy Major ,  Adeline Morel ,  Mihiro Sunose ,  Nelly Piton

发明人： Nigel Ramsden ,  Jeremy Major ,  Adeline Morel ,  Mihiro Sunose ,  Nelly Piton

IPC分类号： A61K31/506 ,  C07D239/48 ,  A61P29/00 ,  C07D405/12 ,  A61P37/08 ,  A61P37/00 ,  A61K31/505 ,  C07D401/12

CPC分类号： C07D239/48

摘要： The invention relates to compounds of formula (I) wherein R1 to R5, X and X1 to X3 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of ZAP-70 for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

摘要翻译： 本发明涉及式（I）化合物，其中R 1至R 5，X和X 1至X 3具有如在说明书和权利要求书中引用的含义。 所述化合物可用作ZAP-70的抑制剂，用于治疗或预防免疫学，炎性，自身免疫性，过敏性疾病和免疫介导的疾病。 本发明还涉及包含所述化合物的药物组合物，这些化合物的制备以及作为药物的用途。

公开(公告)号：US20140378438A1

公开(公告)日：2014-12-25

申请号：US14346332

申请日：2012-09-21

申请人： Rosemary Lynch ,  Andrew David Cansfield ,  Daniel Paul Hardy ,  Mihiro Sunose ,  Adeline Morel ,  Laura Convery ,  Rita Adrego

发明人： Rosemary Lynch ,  Andrew David Cansfield ,  Daniel Paul Hardy ,  Mihiro Sunose ,  Adeline Morel ,  Laura Convery ,  Rita Adrego

IPC分类号： C07D498/08 ,  C07D413/14 ,  C07D413/04

CPC分类号： C07D498/08 ,  C07D251/22 ,  C07D401/12 ,  C07D407/12 ,  C07D413/04 ,  C07D413/14

摘要： The invention relates to compounds of formula (I) wherein m, n, R1, T0 and T1 have the meaning as cited in the description and the claims. The compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds as well as methods of treating mTOR related diseases.

摘要翻译： 本发明涉及式（I）化合物，其中m，n，R 1，T 0和T 1具有在说明书和权利要求书中引用的含义。 该化合物可用作mTOR的抑制剂，用于治疗或预防mTOR相关疾病和病症。 本发明还涉及包含所述化合物的药物组合物以及治疗mTOR相关疾病的方法。