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1.发明申请USE OF MALACHITE GREEN IN THE FORM OF DRUG FOR TREATING MALIGNANT NEOPLASMS 失效用于治疗恶性肿瘤的药物形式中的马拉奇绿色使用公开(公告)号：US20100105776A1
公开(公告)日：2010-04-29
申请号：US12312898
申请日：2006-11-29
IPC分类号： A61K31/191 , C07C55/02 , A61P35/00
CPC分类号： A61K31/14 , A61K31/194
摘要： The use of malachite green in the form of a tetramethyldiamino-triphenyl-carbinol anhydro-oxalate [(C23H25N2)—(C2HO4)]2—C2H2O4 of the following structural formula as a drug for treating malignant neoplasms administered in a single doze of 1 to 2 g. Malachite green can be used when dissolved in an aqueous solution or in a physiological salt solution or in spirit. In different cases, the malachite green solution is perorally administered before and after a meal or is injected per rectum, or a 1% malachite green solution is intravenously introduced, or the malachite green is applied as a rectal suppository component or as a component of 1-5% ointment. The medicinal agent exhibits an extended range of therapeutic actions with respect to different oncological diseases, is freely available, not expensive, non-toxic, does not generate side effects when used in pharmaceutically acceptable doses, and makes it possible to reduce a treating time and to increase the efficiency of treatment.
摘要翻译： 使用以下结构式的四甲基二氨基 - 三苯基 - 甲醇脱草酸盐[（C23H25N2） - （C2HO4）] 2-C2H2O4形式的孔雀石绿作为治疗恶性肿瘤的药物，以单次1〜 2克。 孔雀绿可溶于水溶液或生理盐溶液或精神中使用。 在不同的情况下，孔雀石绿溶液在饭前后经口给药或每个直肠注射，或静脉内引入1％孔雀石绿溶液，或孔雀石绿作为直肠栓剂组分或1成分 -5％软膏。 该药剂对于不同的肿瘤疾病表现出延长的治疗作用范围，可自由获得，不昂贵，无毒，当以药学上可接受的剂量使用时不产生副作用，并且可以减少治疗时间和 提高治疗效率。
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公开(公告)号：US07601133B2
公开(公告)日：2009-10-13
申请号：US10576039
申请日：2004-09-20
CPC分类号： A61M1/3679 , A61M1/1006 , A61M1/1037 , A61M1/1039 , A61M1/3618
摘要： Biology and medicine for cleaning biological fluids. A system for correcting a biological fluid includes a sealed container for a magnetically operated absorbent (MOA), a sealed chamber for mixing the absorbent with a biological fluid and for the absorbent precipitation therefrom, and a sealed filtering unit. The chamber and container are embodied so that they can modify the volumes thereof, have a common interchamber partition-wall fixed to the bottom and are interconnected through a passage embodied in the wall. The other sidewalls of the chambers have corrugations which form bellows. Lids of the chambers are pivotally connected so that they are pivotable around the pivot axis. The MOA container is arranged inside the absorber-mixing chamber and embodied as a bellow. An inlet connection is simultaneously connected to the inside cavities of the absorber-mixing chamber and to the container thereof.
摘要翻译： 用于清洁生物体液的生物学和药物。 用于校正生物流体的系统包括用于磁操作吸收剂（MOA）的密封容器，用于将吸收剂与生物流体混合并用于吸收剂沉淀的密封室和密封过滤单元。 腔室和容器被实施为使得它们可以改变其体积，具有固定到底部并且通过体现在壁中的通道相互连接的共同的室间分隔壁。 腔室的其他侧壁具有形成波纹管的波纹。 腔室的盖子枢转地连接，使得它们可围绕枢转轴线枢转。 MOA容器布置在吸收器 - 混合室的内部并体现为波纹管。 入口连接件同时连接到吸收器 - 混合室的内腔和其容器。
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公开(公告)号：US20120122966A1
公开(公告)日：2012-05-17
申请号：US13138878
申请日：2009-04-14
IPC分类号： A61K31/136 , A61K31/352 , A61P25/04 , A61K31/196
CPC分类号： A61K9/0095 , A61K9/0019 , A61K9/0031 , A61K31/045 , A61K31/136 , A61K31/196 , A61K31/352
摘要： An organic dye from the group of crystal violet, gentian violet, malachite green oxalate and rhodamine 6G used as an analgesic agent in the form of a solution with the agent dosage ranging from 0.000001 mg to 10 g per intake. It is preferable to take the agent at least two times a day. In particular cases of use the agent is administered by mouth in the form of an aqueous solution before or after meals, or it is administered per rectum in the form of an aqueous solution, or a 1% solution of the agent is administered intravenously, or the agent is used in the form of a 1-5% ointment, or the agent is administered per rectum in the form of suppositories, and when arresting cancer pain the agent is injected into the tumor (under the tumor) or into a metastasis. Herein, one uses as analgesic agents widely available and inexpensive substances that are non-toxic, have no allergic effects and cause no addiction (dependence) when used in pharmaceutically acceptable doses; the treatment time is reduced, treatment efficiency is enhanced, and pain relief is provided while preserving patients' functional activity, using the minimum arsenal of analgesic agents with different effects, and completely eliminating the need for opiates.
摘要翻译： 来自结晶紫，龙胆紫，孔雀石绿草酸盐和罗丹明6G的有机染料用作溶液形式的止痛剂，其剂量为每摄入量0.000001mg至10g。 优选每天服用至少两次。 在使用的特别情况下，试剂在饭前或餐后以水溶液的形式口服给药，或以水溶液的形式每直肠施用，或静脉内施用1％的试剂溶液，或 该药剂以1-5％软膏的形式使用，或者以栓剂的形式每个直肠给药，当阻止癌症疼痛时，将药剂注射到肿瘤（肿瘤下）或转移。 这里，作为广泛使用的镇痛剂，使用无毒性的廉价物质，当以药学上可接受的剂量使用时，不会产生过敏反应，不会成瘾（依赖性）; 减少治疗时间，提高治疗效率，同时保持患者的功能活动，使用不同效果的最小剂量的镇痛药，并完全消除对阿片剂的需要，提供疼痛缓解。
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公开(公告)号：US20090305868A1
公开(公告)日：2009-12-10
申请号：US12496396
申请日：2009-07-01
CPC分类号： B01J20/28004 , A61M1/3679 , B01J20/28009 , B01J20/28014 , B01J20/3293 , B82Y25/00 , G01N33/5434 , H01F1/0045 , H01F1/20
摘要： An absorbent includes a ferromagnetic nucleus with a one-layer or two-layer shell or devoid thereof and the nucleus is embodied in the form of a plate with a planar size that ranges from 500-5000 μm and the thickness is equal to 0.1-1000 μm. The method for producing the inventive magnetically-operated absorbent includes evaporating and/or melting a magnetic material powder in a low-temperature plasma, quenching and condensing the thus obtained vaporized and/or melt-particle product in a gas flux, and transferring the product precipitated in the form of crystals or micro slugs of corresponding metals, correspondingly to a stabilizer-containing dispersion medium and holding in the medium until a gas release is over. Then the crystals or micro slugs are processed by flatting, for example pressing so that the plates of a specified thickness are obtained.
摘要翻译： 吸收剂包括具有单层或双层壳或不含其的铁磁核，并且核以具有500-5000μm的平面尺寸并且厚度等于0.1-1000的板的形式体现 妈妈 制造本发明的磁操作吸收剂的方法包括在低温等离子体中蒸发和/或熔化磁性材料粉末，将由此获得的气体和/或熔体颗粒产物冷凝并冷凝在气体助熔剂中，并将产物 以对应于含稳定剂的分散介质的相应金属的晶体或微团块的形式沉淀并保持在介质中直到气体释放结束。 然后，通过平坦化（例如压制）处理晶体或微块，使得获得指定厚度的板。
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公开(公告)号：US20090221708A1
公开(公告)日：2009-09-03
申请号：US11578879
申请日：2005-03-31
IPC分类号： A61K31/192 , A61P29/00 , A61P37/00
CPC分类号： A61K31/192
摘要： Medicine, in particular broad spectrum medicinal preparations. This invention is based on the use of 4-chlorine-2-methyl-phenoxy-acetic acid of formula I, the pharmacologically acceptable derivatives thereof, for example on corresponding alkali metal salts of the acid and the derivatives in the form of pharmaceutical preparations exhibiting immunomodulating, anti-inflammatory and anti-tumoral properties and antiviral activity. The broad spectrum of therapeutic modalities of the inventive medicinal preparation and the fact that it does not produce side effects are proven by study.
摘要翻译： 医药，特别是广谱药用制剂。 本发明基于式I的4-氯-2-甲基 - 苯氧基 - 乙酸，其药学上可接受的衍生物，例如与酸的相应碱金属盐和衍生物形式的药物制剂的展示 免疫调节，抗炎和抗肿瘤性质和抗病毒活性。 本发明药物制剂的广泛的治疗方式和不产生副作用的事实通过研究证明。
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公开(公告)号：US20070071977A1
公开(公告)日：2007-03-29
申请号：US10575830
申请日：2004-09-20
CPC分类号： H01F1/20 , H01F1/33 , Y10T428/2982 , Y10T428/2991
摘要： Biology and medicine that can be used for cleaning biological fluids and for bringing the content to meet physiological standards. An absorbent includes a ferromagnetic nucleus with a one-layer or two-layer shell or devoid thereof and the nucleus is embodied in the form of a plate with a planar size that ranges from 500-5000 □m and the thickness is equal to 0.1-1000 □m. The method for producing the inventive magnetically-operated absorbent includes evaporating and/or melting a magnetic material powder in a low-temperature plasma, quenching and condensing the thus obtained vaporized and/or melt-particle product in a gas flux, and transferring the product precipitated in the form of crystals or micro slugs of corresponding metals, correspondingly to a stabilizer-containing dispersion medium and holding in the medium until a gas release is over. Then the crystals or micro slugs are processed by flatting, for example pressing so that the plates of a specified thickness are obtained. The plates are repeatedly (up to 10 times) washed with distilled water, the weak sections thereof are separated by exposing them in water, for example to the action of ultrasound with power ranges, for example from 200 to 300 W/cm2, and the thus produced plates are dried. The dried plates are broken up, the absorbent nucleuses of a required size are obtained and the shells are formed thereon layer-by-layer. The final product is packed in light-protected sealed containers and sterilized, for example by γ-radiation. The final product can be also selected in the form of an absorbent produced immediately after the fractionation thereof.
摘要翻译： 可用于清洁生物体液和使内容物符合生理标准的生物学和药物。 吸收剂包括具有单层或双层壳或不含它的铁磁核，并且核以具有500-5000μm的平面尺寸并且厚度等于0.1的板的形式体现 1000□m。 制造本发明的磁操作吸收剂的方法包括在低温等离子体中蒸发和/或熔化磁性材料粉末，将由此获得的气体和/或熔体颗粒产物冷凝并冷凝在气体助熔剂中，并将产物 以对应于含稳定剂的分散介质的相应金属的晶体或微团块的形式沉淀并保持在介质中直到气体释放结束。 然后，通过平坦化（例如压制）处理晶体或微块，使得获得指定厚度的板。 重复（最多10次）用蒸馏水洗涤板，其弱部分通过将其暴露在水中而分离，例如超声功能范围的动作，例如200至300W / 2，将如此制得的板干燥。 干燥的板被破碎，获得所需尺寸的吸收核，并且逐层地形成壳。 最终产品包装在防光密封容器中，例如通过γ-辐射灭菌。 最终产品也可以在其分馏后立即选择的吸收剂形式进行选择。
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公开(公告)号：US08436195B2
公开(公告)日：2013-05-07
申请号：US12312898
申请日：2006-11-29
IPC分类号： C09B11/10 , A61K31/136
CPC分类号： A61K31/14 , A61K31/194
摘要： The use of malachite green in the form of a tetramethyldiamino-triphenyl-carbinol anhydro-oxalate [(C23H25N2)—(C2HO4)]2—C2H2O4 of the following structural formula as a drug for treating malignant neoplasms administered in a single dose of 1 to 2 g. Malachite green can be used when dissolved in an aqueous solution or in a physiological salt solution or in spirit. In different cases, the malachite green solution is perorally administered before and after a meal or is injected per rectum, or a 1% malachite green solution is intravenously introduced, or the malachite green is applied as a rectal suppository component or as a component of 1-5% ointment. The medicinal agent exhibits an extended range of therapeutic actions with respect to different oncological diseases, is freely available, not expensive, non-toxic, does not generate side effects when used in pharmaceutically acceptable doses, and makes it possible to reduce a treating time and to increase the efficiency of treatment.
摘要翻译： 使用以下结构式的四甲基二氨基 - 三苯基 - 甲醇脱草酸盐[（C23H25N2） - （C2HO4）] 2-C2H2O4形式的孔雀石绿作为治疗恶性肿瘤的药物，以单剂量1至 2克。 孔雀绿可溶于水溶液或生理盐溶液或精神中使用。 在不同的情况下，孔雀石绿溶液在饭前后经口给药或每个直肠注射，或静脉内引入1％孔雀石绿溶液，或孔雀石绿作为直肠栓剂组分或1成分 -5％软膏。 该药剂对于不同的肿瘤疾病表现出延长的治疗作用范围，可自由获得，不昂贵，无毒，当以药学上可接受的剂量使用时不产生副作用，并且可以减少治疗时间和 提高治疗效率。
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公开(公告)号：US07888284B2
公开(公告)日：2011-02-15
申请号：US12496396
申请日：2009-07-01
IPC分类号： B01J20/00
CPC分类号： B01J20/28004 , A61M1/3679 , B01J20/28009 , B01J20/28014 , B01J20/3293 , B82Y25/00 , G01N33/5434 , H01F1/0045 , H01F1/20
摘要： An absorbent includes a ferromagnetic nucleus with a one-layer or two-layer shell or devoid thereof and the nucleus is embodied in the form of a plate with a planar size that ranges from 500-5000 μm and the thickness is equal to 0.1-1000 μm. The method for producing the inventive magnetically-operated absorbent includes evaporating and/or melting a magnetic material powder in a low-temperature plasma, quenching and condensing the thus obtained vaporized and/or melt-particle product in a gas flux, and transferring the product precipitated in the form of crystals or micro slugs of corresponding metals, correspondingly to a stabilizer-containing dispersion medium and holding in the medium until a gas release is over. Then the crystals or micro slugs are processed by flattening, for example pressing so that the plates of a specified thickness are obtained.
摘要翻译： 吸收剂包括具有单层或双层壳或缺乏它的铁磁核，并且核以具有500-5000μm的平面尺寸并且厚度等于0.1-1000的板的形式体现 μm。 制造本发明的磁操作吸收剂的方法包括在低温等离子体中蒸发和/或熔化磁性材料粉末，将由此获得的气体和/或熔体颗粒产物冷凝并冷凝在气体助熔剂中，并将产物 以对应于含稳定剂的分散介质的相应金属的晶体或微团块的形式沉淀并保持在介质中直到气体释放结束。 然后通过压平（例如压制）来处理晶体或微型块，使得获得特定厚度的板。
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公开(公告)号：US20100280125A1
公开(公告)日：2010-11-04
申请号：US12834627
申请日：2010-07-12
IPC分类号： A61K31/135 , A61P37/04
CPC分类号： A61K31/14
摘要： Medicine and pharmacology, in particular a medicinal agent exhibiting anti-tumoral and immunomodulatory actions and including a tri-p-amino-thiphenyl-chlormethan tetramethylated, pentamethylated or hexamethylated derivative, the mixtures thereof or the combination thereof with dextrin. The agent of this invention exhibits a high activity and a reduced side effect.
摘要翻译： 医药和药理学，特别是具有抗肿瘤和免疫调节作用的药物，包括三对氨基 - 联苯 - 氯代甲烷四甲基化，五甲基化或六甲基化衍生物，其混合物或其与糊精的组合。 本发明的药剂具有高活性和降低副作用。
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