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    Activatable Two-Component Photosensitizers
    4.
    发明申请
    Activatable Two-Component Photosensitizers 审中-公开

    公开(公告)号：US20200078460A1

    公开(公告)日：2020-03-12

    申请号：US16568886

    申请日：2019-09-12

    Applicant: Carnegie Mellon University

    Inventor： Marcel P. Bruchez ,  Jianjun He ,  Yi Wang

    IPC: A61K41/00 ,  C09B11/22 ,  C07K14/71 ,  C07K14/00 ,  A61N5/06 ,  C09B11/10 ,  C07C233/40 ,  C07C233/36 ,  C07C211/43 ,  A61K47/64

    Abstract: Provided herein is a two-component photosensitizer, which demonstrated robust and selective killing effects for transfected HEK cells and affibody targeted A431 cancer cells when exposed to near infrared light excitation. Free MG2I is a pure and stable fluorogen; it is easy to synthesize and modify, and has no toxicity to cells. Unlike conventional photosensitizers, the dye and FAP itself has no photosensitizing effect until they are bound. Also unlike other activation methods, the activation step is achieved by adding the fluorogen, not the presence of the targeted molecule, requiring an ‘active’ activation instead of a ‘passive’ activation. This method offers the ability to locally switch-on and selective generation of singlet oxygen at the target site and can be used for a wide variety of molecular targets.

    Activatable two-component photosensitizers
    5.
    发明授权
    Activatable two-component photosensitizers 有权

    公开(公告)号：US10434177B2

    公开(公告)日：2019-10-08

    申请号：US15527061

    申请日：2015-11-17

    Applicant: Carnegie Mellon University

    Inventor： Marcel P. Bruchez ,  Jianjun He ,  Yi Wang

    IPC: A61K41/00 ,  C07C211/43 ,  C07C233/36 ,  C07C233/40 ,  C09B11/10 ,  A61K47/64 ,  A61N5/06 ,  C07K14/00 ,  C07K14/71 ,  C09B11/22

    Abstract: Provided herein is a two-component photosensitizer, which demonstrated robust and selective killing effects for transfected HEK cells and affibody targeted A431 cancer cells when exposed to near infrared light excitation. Free MG2I is a pure and stable fluorogen; it is easy to synthesize and modify, and has no toxicity to cells. Unlike conventional photosensitizers, the dye and FAP itself has no photosensitizing effect until they are bound. Also unlike other activation methods, the activation step is achieved by adding the fluorogen, not the presence of the targeted molecule, requiring an ‘active’ activation instead of a ‘passive’ activation. This method offers the ability to locally switch-on and selective generation of singlet oxygen at the target site and can be used for a wide variety of molecular targets.

    Preparation of Di- or triarylmethane dyes by oxidation
    9.
    发明授权
    Preparation of Di- or triarylmethane dyes by oxidation 失效
    通过氧化制备二 - 或三芳基甲烷染料

    公开(公告)号：US5659053A

    公开(公告)日：1997-08-19

    申请号：US615065

    申请日：1996-03-13

    Applicant: Thomas Gessner ,  Udo Mayer

    Inventor： Thomas Gessner ,  Udo Mayer

    IPC: C09B11/02 ,  C09B11/18 ,  C09B11/04 ,  C09B11/10

    CPC classification number: C09B11/02 ,  C09B11/18

    Abstract: A process for preparing di- or triarylmethane dyes by oxidation of di- or triarylmethanes in the presence of a diluent and of an oxygen transfer catalyst that contains a complexed heavy metal ion comprises using as oxidizing agent hydrogen peroxide, a hydrogen peroxide donor compound, an organic hydroperoxide or a percarboxylic acid and as the oxygen transfer catalyst a member of the class of the porphyrins, tetraaza[14]annulenes, phthalocyanines or tetraazacyclotetradecanes.

    Abstract translation: 在稀释剂和含有复合重金属离子的氧转移催化剂存在下，通过氧化二芳基甲烷或三芳基甲烷制备二芳基甲烷或三芳基甲烷染料的方法包括使用过氧化氢，过氧化氢供体化合物， 有机氢过氧化物或过羧酸，并且作为氧转移催化剂是卟啉类，四氮杂萘，酞菁或四氮杂环十四烷的成员。

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