公开(公告)号：US20060194231A1

公开(公告)日：2006-08-31

申请号：US11340145

申请日：2006-01-25

申请人： Milan Stojanovic ,  Sergei Rudchenko

发明人： Milan Stojanovic ,  Sergei Rudchenko

IPC分类号： C12Q1/68

CPC分类号： G01N33/5308 ,  C12Q1/6837 ,  C12Q2565/626 ,  C12Q2563/149

摘要： Cross-reactive arrays on encoded beads are used to correlate ‘fingerprints’ of urine, serum and other biological liquids to disease states. Fluorescent hydrophobic sensors are based on nucleic acid three-way junctions, and beads may be encoded by size (could be registered by light scattering) and fluorescence in combination with flow cytometry analysis, also known as suspension array technology (SAT).

摘要翻译： 编码珠上的交叉反应阵列用于将尿液，血清和其他生物液体的“指纹”与疾病状态相关联。 荧光疏水传感器基于核酸三向接头，珠可以通过尺寸（可以通过光散射记录）和荧光结合流式细胞术分析（也称为悬浮阵列技术（SAT））编码。

公开(公告)号：US20160153989A1

公开(公告)日：2016-06-02

申请号：US14931941

申请日：2015-11-04

申请人： Milan N. Stojanovic ,  Sergei Rudchenko ,  Maria Rudchenko ,  Steven Taylor

发明人： Milan N. Stojanovic ,  Sergei Rudchenko ,  Maria Rudchenko ,  Steven Taylor

IPC分类号： G01N33/569

CPC分类号： G01N33/56966 ,  G01N2333/705

摘要： Provided herein are molecular automaton systems for identification, isolation, or elimination of a target biological object. Some embodiments include modules specific for a target biological object having a first biological object surface marker and a second biological object surface marker. Some embodiments include modules specific for a target biological object having a first biological object surface marker but not a second biological object surface marker.

摘要翻译： 本文提供了用于鉴定，分离或消除靶生物的物质的分子自动机系统。 一些实施方案包括特定于具有第一生物物体表面标记和第二生物物体表面标记的靶生物的物质的模块。 一些实施方案包括对具有第一生物物体表面标记而不是第二生物物体表面标记的目标生物体特异性的模块。

公开(公告)号：US07820400B2

公开(公告)日：2010-10-26

申请号：US11453186

申请日：2006-06-13

申请人： Ilya Trakht ,  Robert Canfield ,  Gary Kalantarov ,  Sergei Rudchenko

发明人： Ilya Trakht ,  Robert Canfield ,  Gary Kalantarov ,  Sergei Rudchenko

IPC分类号： G01N33/574

CPC分类号： G01N33/57407 ,  C07K16/28 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/77 ,  C12N5/163 ,  C12N5/166 ,  C12N2510/02 ,  C12N2510/04 ,  G01N33/57492

摘要： The present invention provides monoclonal antibody-producing hybridomas designated 27.F7 and 27.B1. The invention provides a method of detecting TIP-2 antigen bearing cancer cells in a sample. The invention provides a method of detecting TIP-2 antigen on the surface of cancer cells. The invention provides a method for diagnosing cancer in a subject. The invention provides a method for delivering exogenous material to TIP-2 antigen-bearing cancer cells of a human subject. The invention provides a method for treating cancer in a human subject. The invention provides isolated peptides having the amino acid sequences Lys Leu Leu Gly Gly Gln Ile Gly Leu (SEQ. ID No.) and Ser Leu Leu Gly Cys Arg His Tyr Glu Val (SEQ. ID No.). The invention provides a method for immunohistochemical screening of a tissue section for the presence of TIP-2 antigen bearing cancer cells. The invention provides a kit for detecting the presence of TIP-2 antigen-bearing cancer cells. The invention provides a method for detecting the presence of TIP-2 antigen. The invention provides a method for immunohistochemical screening of tissue sections. The invention provides a method for monitoring progression of cancer wherein the cancer cells are TIP-2 antigen-bearing cells. The invention provides a method for diagnosing cancer associated with the expression of TIP-2.

摘要翻译： 本发明提供了称为27.F7和27.B1的产生单克隆抗体的杂交瘤。 本发明提供一种检测样品中携带TIP-2抗原的癌细胞的方法。 本发明提供了检测癌细胞表面的TIP-2抗原的方法。 本发明提供了一种用于诊断受试者的癌症的方法。 本发明提供了将外源性材料递送至人受试者的TIP-2抗原携带癌细胞的方法。 本发明提供了一种治疗人类受试者的癌症的方法。 本发明提供具有氨基酸序列Lys Leu Leu Gly Gly Gln Ile Gly Leu（SEQ ID NO）和Ser Leu Leu Gly Cys Arg His Tyr Glu Val的分离肽（SEQ ID NO：SEQ ID NO： 本发明提供了一种组织切片对于携带TIP-2抗原的癌细胞存在的免疫组织化学筛选方法。 本发明提供了用于检测携带TIP-2抗原的癌细胞的存在的试剂盒。 本发明提供了检测TIP-2抗原存在的方法。 本发明提供了组织切片的免疫组织化学筛选方法。 本发明提供了一种监测癌症进展的方法，其中癌细胞是携带TIP-2抗原的细胞。 本发明提供了一种诊断与TIP-2表达相关的癌症的方法。

公开(公告)号：US20060292644A1

公开(公告)日：2006-12-28

申请号：US11453186

申请日：2006-06-13

申请人： Ilya Trakht ,  Robert Canfield ,  Gary Kalantarov ,  Sergei Rudchenko

发明人： Ilya Trakht ,  Robert Canfield ,  Gary Kalantarov ,  Sergei Rudchenko

IPC分类号： G01N33/574 ,  C12N5/06 ,  C07K16/30

CPC分类号： G01N33/57407 ,  C07K16/28 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/77 ,  C12N5/163 ,  C12N5/166 ,  C12N2510/02 ,  C12N2510/04 ,  G01N33/57492

摘要： The present invention provides monoclonal antibody-producing hybridomas designated 27.F7 and 27.B1. The invention provides a method of detecting TIP-2 antigen bearing cancer cells in a sample. The invention provides a method of detecting TIP-2 antigen on the surface of cancer cells. The invention provides a method for diagnosing cancer in a subject. The invention provides a method for delivering exogenous material to TIP-2 antigen-bearing cancer cells of a human subject. The invention provides a method for treating cancer in a human subject. The invention provides isolated peptides having the amino acid sequences Lys Leu Leu Gly Gly Gln Ile Gly Leu (SEQ. ID No.) and Ser Leu Leu Gly Cys Arg His Tyr Glu Val (SEQ. ID No.). The invention provides a method for immunohistochemical screening of a tissue section for the presence of TIP-2 antigen bearing cancer cells. The invention provides a kit for detecting the presence of TIP-2 antigen-bearing cancer cells. The invention provides a method for detecting the presence of TIP-2 antigen. The invention provides a method for immunohistochemical screening of tissue sections. The invention provides a method for monitoring progression of cancer wherein the cancer cells are TIP-2 antigen-bearing cells. The invention provides a method for diagnosing cancer associated with the expression of TIP-2.

摘要翻译： 本发明提供了称为27.F7和27.B1的产生单克隆抗体的杂交瘤。 本发明提供一种检测样品中携带TIP-2抗原的癌细胞的方法。 本发明提供了检测癌细胞表面的TIP-2抗原的方法。 本发明提供了一种用于诊断受试者的癌症的方法。 本发明提供了将外源性材料递送至人受试者的TIP-2抗原携带癌细胞的方法。 本发明提供了一种治疗人类受试者的癌症的方法。 本发明提供具有氨基酸序列Lys Leu Leu Gly Gly Gln Ile Gly Leu（SEQ ID NO）和Ser Leu Leu Gly Cys Arg His Tyr Glu Val的分离肽（SEQ ID NO：SEQ ID NO： 本发明提供了一种组织切片对于携带TIP-2抗原的癌细胞存在的免疫组织化学筛选方法。 本发明提供了用于检测携带TIP-2抗原的癌细胞的存在的试剂盒。 本发明提供了检测TIP-2抗原存在的方法。 本发明提供了组织切片的免疫组织化学筛选方法。 本发明提供了一种监测癌症进展的方法，其中癌细胞是携带TIP-2抗原的细胞。 本发明提供了一种诊断与TIP-2表达相关的癌症的方法。

公开(公告)号：US07060802B1

公开(公告)日：2006-06-13

申请号：US09664958

申请日：2000-09-18

申请人： Ilya Trakht ,  Robert Canfield ,  Gary Kalantarov ,  Sergei Rudchenko

发明人： Ilya Trakht ,  Robert Canfield ,  Gary Kalantarov ,  Sergei Rudchenko

IPC分类号： C07K16/00

CPC分类号： G01N33/57407 ,  C07K16/28 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/77 ,  C12N5/163 ,  C12N5/166 ,  C12N2510/02 ,  C12N2510/04 ,  G01N33/57492

摘要： This invention provides monoclonal antibody-producing hybridomas designated 27.F7 and 27.B1. The invention also provides methods for detecting TIP-2 antigen-bearing cancer cells in a sample, detecting the presence of TIP-2 antigen, optionally on the surface of cancer cells, immunohistochemical screening of a tissue section for the presence of TIP-2 antigen bearing cancer cells, diagnosing cancer in a subject, monitoring progression of cancer wherein the cancer cells are TIP-2 antigen-bearing cells, delivering exogenous material to TIP-2 antigen-bearing cancer cells of a human subject, and treating cancer in a human subject. This invention further provides a kit for detecting the presence of TIP-2 antigen-bearing cancer cells. This invention also provides isolated peptides having the amino acid sequences Lys Leu Leu Gly Gly Gln Ile Gly Leu (SEQ ID No:3) and Ser Leu Leu Gly Cys Arg His Tyr Glu Val (SEQ ID NO:4).

摘要翻译： 本发明提供了称为27.F7和27.B1的产生单克隆抗体的杂交瘤。 本发明还提供了用于检测样品中TIP-2抗原的癌细胞的方法，任选地在癌细胞表面检测TIP-2抗原的存在，组织切片的TIP-2抗原的存在的免疫组织化学筛选 诊断受试者中的癌症，监测癌症的进展，其中癌细胞是TIP-2抗原携带细胞，将外源性物质递送到人受试者的TIP-2抗原携带癌细胞，以及治疗人类的癌症 学科。 本发明还提供了用于检测携带TIP-2抗原的癌细胞的存在的试剂盒。 本发明还提供了具有氨基酸序列Lys Leu Leu Gly Gly Gln Ile Gly Leu（SEQ ID No.3）和Ser Leu Leu Gly Cys Arg His Tyr Glu Val（SEQ ID NO：4）的分离肽。