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    Medicament coated refractive anterior chamber ocular implant
    3.
    发明授权
    Medicament coated refractive anterior chamber ocular implant 失效
    药物涂层折叠前房眼植入物

    公开(公告)号：US5652014A

    公开(公告)日：1997-07-29

    申请号：US193160

    申请日：1994-08-25

    申请人： Miles A. Galin ,  Joseph C. Salamone ,  Stanley C. Israel

    发明人： Miles A. Galin ,  Joseph C. Salamone ,  Stanley C. Israel

    IPC分类号： A61F2/14 ,  A61L27/00 ,  A61L27/34 ,  A61L33/00 ,  A61F2/16

    CPC分类号： A61F2/1605 ,  A61F2/147 ,  A61L27/34 ,  A61L33/0011 ,  A61L33/0094 ,  A61L2430/16 ,  Y10S623/901

    摘要： A minus power anterior chamber ocular implant for placement in the anterior chamber of a phakic eye having an anatomic lens in situ comprises a negative artificial refracting lens having at least one concave surface, a surface coating which comprises a compatible sulfated polysaccharide medicament coating, such as heparin, and and having a structure which positions having a structure which positions the artificial lens in the anterior chamber of the eye to prevent contact between the implant and the anatomic lens. The implant compensates for refractive errors or creates a specific refraction to assist in visual function and has increased biocompatibility in the anterior chamber of the eye, thereby preventing or mitigating detrimental effects typically associated with the implantation of an uncoated refractive anterior chamber implant in the eye. A method of preparing such a minus power anterior chamber ocular implant comprises first exposing an uncoated implant to a plasma to generate a plasma-treated implant having a surface containing amines, carboxylic acids, active free radicals or passive free radicals, and thereafter bonding the medicament to the plasma-treated implant surface. A method of treating myopia comprises surgically implanting and anchoring the implant in the phakic eye to compensate for refractive errors.

    摘要翻译： PCT No.PCT / US92 / 06818 Sec。 371日期：1994年8月25日 102（e）日期1994年8月25日PCT提交1992年8月13日PCT公布。 公开号WO93 / 03776 日期1993年3月4日一种用于放置在具有解剖镜片的晶状体眼的前房中的负功率前房眼植入物包括具有至少一个凹表面的负人造折射透镜，包含相容的硫酸化多糖的表面涂层 药物包衣，例如肝素，并且具有将人造镜片定位在眼前房中的结构的结构，以防止植入物和解剖镜片之间的接触。 植入物补偿屈光不正或产生特定折射以辅助视觉功能，并且增加眼睛前房中的生物相容性，从而防止或减轻通常与眼睛中未涂覆的折射性前房植入物植入有关的有害影响。 制备这种负电源前房眼植入物的方法包括首先将未涂覆的植入物暴露于等离子体以产生具有包含胺，羧酸，活性自由基或被动自由基的表面的等离子体处理的植入物，然后将药物 到等离子体处理的植入物表面。 治疗近视的方法包括将植入物手术植入和固定在晶状体眼中以补偿屈光不正。

    Medicament coated refractive anterior chamber ocular implant
    4.
    发明授权
    Medicament coated refractive anterior chamber ocular implant 失效

    公开(公告)号：US5944753A

    公开(公告)日：1999-08-31

    申请号：US815895

    申请日：1997-03-12

    申请人： Miles A. Galin ,  Joseph C. Salamone ,  Stanley C. Israel

    发明人： Miles A. Galin ,  Joseph C. Salamone ,  Stanley C. Israel

    IPC分类号： A61F2/14 ,  A61L27/00 ,  A61L27/34 ,  A61L33/00 ,  A61F2/16

    CPC分类号： A61F2/1605 ,  A61F2/147 ,  A61L27/34 ,  A61L33/0011 ,  A61L33/0094 ,  A61L2430/16 ,  Y10S623/901

    摘要： A minus power anterior chamber ocular implant for placement in the anterior chamber of a phakic eye having an anatomic lens in situ comprises a negative artificial refracting lens having at least one concave surface, a surface coating which comprises a compatible sulfated polysaccharide medicament coating, such as heparin, and having a structure which positions the artificial lens in the anterior chamber of the eye to prevent contact between the implant and the anatomic lens. The implant compensates for refractive errors or creates a specific refraction to assist in visual function and has increased biocompatibility in the anterior chamber of the eye, thereby preventing or mitigating detrimental effects typically associated with the implantation of an uncoated refractive anterior chamber implant in the eye. A method of preparing such a minus power anterior chamber ocular implant comprises first exposing an uncoated implant to a plasma to generate a plasma-treated implant having a surface containing amines, carboxylic acids, active free radicals or passive free radicals, and thereafter bonding the medicament to the plasma-treated implant surface. A method of treating myopia comprises surgically implanting and anchoring the implant in the phakic eye to compensate for refractive errors.

    Medicament coated refractive anterior chamber ocular implant
    6.
    发明授权
    Medicament coated refractive anterior chamber ocular implant 失效
    药物涂层折叠前房眼植入物

    公开(公告)号：US6143028A

    公开(公告)日：2000-11-07

    申请号：US063624

    申请日：1998-04-20

    申请人： Miles A. Galin ,  Joseph C. Salamone ,  Stanley C. Israel

    发明人： Miles A. Galin ,  Joseph C. Salamone ,  Stanley C. Israel

    IPC分类号： A61F2/14 ,  A61L27/00 ,  A61L27/34 ,  A61L33/00 ,  A61F2/16

    CPC分类号： A61F2/1605 ,  A61F2/147 ,  A61L27/34 ,  A61L33/0011 ,  A61L33/0094 ,  A61L2430/16 ,  Y10S623/901

    摘要： A minus power anterior chamber ocular implant for placement in the anterior chamber of a phakic eye having an anatomic lens in situ comprises a negative artificial refracting lens having at least one concave surface, a surface coating which comprises a compatible sulfated polysaccharide medicament coating, such as heparin, and having a structure which positions the artificial lens in the anterior chamber of the eye to prevent contact between the implant and the anatomic lens. The implant compensates for refractive errors or creates a specific refraction to assist in visual function and has increased biocompatibility in the anterior chamber of the eye, thereby preventing or mitigating detrimental effects typically associated with the implantation of an uncoated refractive anterior chamber implant in the eye. A method of preparing such a minus power anterior chamber ocular implant comprises first exposing an uncoated implant to a plasma to generate a plasma-treated implant having a surface containing amines, carboxylic acids, active free radicals or passive free radicals, and thereafter bonding the medicament to the plasma-treated implant surface. A method of treating myopia comprises surgically implanting and anchoring the implant in the phakic eye to compensate for refractive errors.

    摘要翻译： 用于放置在具有解剖镜片的晶状体眼的前房中的负功率前房眼植入物包括具有至少一个凹表面的负人造折射透镜，包含相容的硫酸化多糖药物涂层的表面涂层，例如 肝素，并且具有将人造镜片定位在眼睛前房中以防止植入物和解剖镜片之间接触的结构。 植入物补偿屈光不正或产生特定折射以辅助视觉功能，并且增加眼睛前房中的生物相容性，从而防止或减轻通常与眼睛中未涂覆的折射性前房植入物植入有关的有害影响。 制备这种负电源前房眼植入物的方法包括首先将未涂覆的植入物暴露于等离子体以产生具有包含胺，羧酸，活性自由基或被动自由基的表面的等离子体处理的植入物，然后将药物 到等离子体处理的植入物表面。 治疗近视的方法包括将植入物手术植入和固定在晶状体眼中以补偿屈光不正。

    Process for the terminal sterilization of intraocular lens
    9.
    发明授权
    Process for the terminal sterilization of intraocular lens 失效
    眼内透镜末端灭菌方法

    公开(公告)号：US4305905A

    公开(公告)日：1981-12-15

    申请号：US170592

    申请日：1980-07-21

    申请人： Miles A. Galin

    发明人： Miles A. Galin

    IPC分类号： A61L12/12 ,  A01N59/00 ,  A61L2/18

    CPC分类号： A61L12/12

    摘要： Intraocular lenses are terminally sterilized without any significant chemical change in the surface of the lenses by placing the intraocular lenses in a 5% to 10% sodium hydroxide solution for from 24 hours to 3 hours, respectively, and storing the intraocular lenses in the same solution until they are used.

    摘要翻译： 通过将眼内透镜分别放置在5％至10％氢氧化钠溶液中24小时至3小时，将眼内透镜终端灭菌，而不会在镜片表面发生任何显着的化学变化，并将眼内透镜保存在同一溶液中 直到它们被使用。

    Fixation of intraocular lenses
    10.
    发明授权
    Fixation of intraocular lenses 失效
    人工晶状体的固定

    公开(公告)号：US4443441A

    公开(公告)日：1984-04-17

    申请号：US290854

    申请日：1981-08-07

    申请人： Miles A. Galin

    发明人： Miles A. Galin

    IPC分类号： A61K9/00 ,  A61K31/22 ,  A61L27/16 ,  A61K31/33 ,  A61K31/135 ,  A61K31/415

    CPC分类号： A61K31/22 ,  A61K9/0048 ,  A61L27/16 ,  Y10S514/912

    摘要： The fixation of an intraocular lens is aided by instilling into an eye having an intraocular lens about one drop of an ophthalmic solution containing an .alpha.-adrenergic blocking agent, such as thymoxamine, in a concentration of from about 0.1% to about 1% by weight, preferably about 0.5% by weight.

    摘要翻译： 通过将浓度为约0.1重量％至约1重量％的浓度滴加入具有约1滴含有α-肾上腺素能阻断剂（例如胸腺嘧啶）的眼用溶液的眼内透镜的眼睛来辅助眼内透镜的固定 ，优选约0.5重量％。