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公开(公告)号：US4098815A
公开(公告)日：1978-07-04
申请号：US751951
申请日：1976-12-17
申请人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
发明人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
IPC分类号： C07C45/56 , C07C45/66 , C07C405/00 , C07C177/00
CPC分类号： C07C405/00 , C07C45/567 , C07C45/66 , Y10S514/826
摘要： The present invention relates to novel not naturally occurring analogues of prostanoic acids of the formula ##STR1## as well as a process for their preparation. The compounds of the invention have valuable pharmacological properties similar to those of the natural prostaglandins and therefore can be used as medicaments.
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公开(公告)号：US4174458A
公开(公告)日：1979-11-13
申请号：US902404
申请日：1978-05-03
申请人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
发明人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
IPC分类号： C07C405/00 , C07C177/00
CPC分类号： C07C405/00
摘要： The present invention relates to novel not naturally occurring analogues of prostanoic acids of the formula ##STR1## as well as a process for their preparation. The compounds of the invention have valuable pharmacological properties similar to those of the natural prostaglandins and therefore can be used as medicaments.
摘要翻译： 本发明涉及式（I）的前列腺酸的新型非天然存在的类似物以及它们的制备方法。 本发明的化合物具有与天然前列腺素类似的有价值的药理学性质，因此可用作药物。
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公开(公告)号：US4024181A
公开(公告)日：1977-05-17
申请号：US525174
申请日：1974-11-19
申请人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
发明人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
IPC分类号： C07D319/08 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07D339/06 , C07D493/08 , C07C177/00
CPC分类号： C07C405/00 , C07D339/06 , Y10S514/826 , Y10S514/869
摘要： The present invention relates to novel not naturally occuring analogues of prostanoic acids of the formula ##STR1## as well as a process for their preparation. The compounds of the invention have valuable pharmacological properties similar to those of the natural prostaglandins and therefore can be used as medicaments.
摘要翻译： 本发明涉及式（I）的前列腺酸的新的非天然存在的类似物以及它们的制备方法。 本发明的化合物具有与天然前列腺素类似的有价值的药理学性质，因此可用作药物。
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公开(公告)号：US4097496A
公开(公告)日：1978-06-27
申请号：US698842
申请日：1976-06-23
申请人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
发明人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
IPC分类号： C07C405/00
CPC分类号： C07C405/00
摘要： The present invention relates to novel not naturally occurring 10,11-dihydro-derivatives of prostaglandins of the A-series as well as a process for their preparation. The compounds of the invention have an antiprostaglandin effect and may be used as medicaments for the inhibition or suppression of pharmacological properties of the prostaglandins.
摘要翻译： 本发明涉及A系列前列腺素的新型非天然存在的10,11-二氢衍生物及其制备方法。 本发明的化合物具有抗前列腺素效应，可用作抑制或抑制前列腺素药理学性质的药物。
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公开(公告)号：US3984459A
公开(公告)日：1976-10-05
申请号：US480319
申请日：1974-06-17
申请人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
发明人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
IPC分类号： C07D307/16 , A61K31/22 , A61K31/557 , C07C51/08 , C07C53/19 , C07C59/68 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/33 , C07D307/54 , C07D309/12 , C07C177/00
CPC分类号： C07C253/14 , C07C405/00 , C07C51/08 , C07C53/19 , C07C59/68 , C07D309/12
摘要： The present invention relates to novel not naturally occurring 10,11-dihydro-derivatives of prostaglandins of the A-series as well as a process for their preparation. The compounds of the invention have an antiprostaglandin effect and may be used as medicaments for the inhibition or suppression pharmacological properties of the prostaglandins.
摘要翻译： 本发明涉及A系列前列腺素的新型非天然存在的10,11-二氢衍生物及其制备方法。 本发明的化合物具有抗前列腺素效应，可用作抑制或抑制前列腺素药理学特性的药物。
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公开(公告)号：US4083990A
公开(公告)日：1978-04-11
申请号：US698843
申请日：1976-06-23
申请人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
发明人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
IPC分类号： C07C405/00 , C07C177/00 , C07D309/06
CPC分类号： C07C405/00
摘要： The present invention relates to novel not naturally occurring 10,11-dihydro-derivatives of prostaglandins of the A-series as well as a process for their preparation. The compounds of the invention have an antiprostaglandin effect and may be used as medicaments for the inhibition or suppression of pharmacological properties of the prostaglandins.
摘要翻译： 本发明涉及A系列前列腺素的新型非天然存在的10,11-二氢衍生物及其制备方法。 本发明的化合物具有抗前列腺素效应，可用作抑制或抑制前列腺素药理学性质的药物。
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公开(公告)号：US4078081A
公开(公告)日：1978-03-07
申请号：US582927
申请日：1975-06-02
申请人： Ulrich Lerch , Milos Babej , Wilhelm Bartmann , Rudolf Kunstmann
发明人： Ulrich Lerch , Milos Babej , Wilhelm Bartmann , Rudolf Kunstmann
IPC分类号： A61K31/21 , C07C67/00 , C07C401/00 , C07C405/00 , C07C177/00 , A61K31/19 , A61K31/215
CPC分类号： C07C405/00
摘要： The present invention relates to new cyclopentane derivatives having the formula ##STR1## and to a process for their manufacture. The compounds can be used as medicaments due to their antiprostaglandin effect.
摘要翻译： 本发明涉及具有式“IMAGE”I的新环戊烷衍生物及其制备方法。 这些化合物由于其抗前列腺素的作用可用作药物。
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公开(公告)号：US4078083A
公开(公告)日：1978-03-07
申请号：US659239
申请日：1976-02-19
申请人： Milos Babej , Wilhelm Bartmann , Ulrich Lerch
发明人： Milos Babej , Wilhelm Bartmann , Ulrich Lerch
IPC分类号： C07D307/16 , A61K31/557 , A61K31/5575 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/54 , C07D309/12 , C07C177/00 , A61K31/19
CPC分类号： C07C405/00 , C07D307/54 , Y10S514/826 , Y10S514/87
摘要： New derivatives of prostanoic acids are described as well as a process for their manufacture. The new compounds show valuable pharmacological activities and can be used for treating e.g. asthma bronchiale, high blood pressure and edema.
摘要翻译： 描述了前列腺酸的新衍生物及其制备方法。 新化合物显示出有价值的药理活性，并可用于治疗。 哮喘支气管，高血压和水肿。
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公开(公告)号：US4071530A
公开(公告)日：1978-01-31
申请号：US628479
申请日：1975-11-04
IPC分类号： C07D207/26 , C07D207/277
CPC分类号： C07D207/26 , C07D207/277
摘要： The present invention relates to pyrrolidone derivatives which are analogous to natural prostaglandins and to a process for preparing the same. The compounds according to the present invention have prostaglandin-like properties and may be used as pharmaceuticals.
摘要翻译： 本发明涉及类似于天然前列腺素的吡咯烷酮衍生物及其制备方法。 根据本发明的化合物具有前列腺素样特性并且可以用作药物。
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公开(公告)号：US4061671A
公开(公告)日：1977-12-06
申请号：US563973
申请日：1975-04-01
申请人： Gerhard Beck , Rudolf Kunstmann , Milos Babej , Hermann Teufel
发明人： Gerhard Beck , Rudolf Kunstmann , Milos Babej , Hermann Teufel
IPC分类号： A61K31/557 , A61K31/5575 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07D309/12 , C07F9/38 , C07F9/40 , C07C177/00
CPC分类号： C07D307/935 , C07C405/00 , C07D309/12
摘要： The present invention relates to analogues of prostanoic acids of the formula I ##STR1## their physiologically acceptable salts with organic and inorganic bases, their esters with aliphatic, cycloaliphatic or araliphatic alcohols and to a process for the manufacture of these compounds.The compounds according to the invention have valuable pharmacological properties and can be used as medicaments.
摘要翻译： 本发明涉及式I的前列腺酸类似物，其有机和无机碱的生理上可接受的盐，它们与脂肪族，脂环族或芳脂族醇的酯类，以及这些化合物的制备方法。
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