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14 条记录 (耗时 0.022 秒)

    1,4-Dihydro-2H-isoquinoline derivatives
    7.
    发明授权
    1,4-Dihydro-2H-isoquinoline derivatives 失效
    1,4-二氢-2H-异喹啉衍生物

    公开(公告)号：US4066764A

    公开(公告)日：1978-01-03

    申请号：US679782

    申请日：1976-04-23

    申请人： Rudolf Kunstmann ,  Joachim Kaiser

    发明人： Rudolf Kunstmann ,  Joachim Kaiser

    IPC分类号： C07D217/22 ,  C07D217/24 ,  C07D471/10 ,  A61K31/535

    CPC分类号： C07D471/10 ,  C07D217/22 ,  C07D217/24 ,  Y10S514/821

    摘要： 1,4-Dihydro-2H-isoquinoline derivatives of the general formula 1 ##STR1## in which R.sup.1 represents hydrogen or straight chain or branched alkyl of 1 to 6 carbon atoms,R.sup.2 represents low molecular dialkylaminoalkyl, in which both alkyl groups of the dialkylamino group together with the nitrogen atom may also form a 5-, 6- or 7-membered saturated ring in which one carbon atom may be substituted by an oxygen atom, a sulfur atom or another nitrogen atom which may be substituted by hydrogen, C.sub.1 -C.sub.4 -alkyl or phenyl, or R.sup.1 and R.sup.2 together may form a 5-or 6-membered saturated ring containing 1 nitrogen atom,R.sup.3 represents phenyl which may be mono- or di-substituted by halogen, nitro, amino or sulfamoyl, or acylamino or alkyl each containing 1 to 4 carbon atoms, or pyridylR.sup.4 andR.sup.5, which may identical or different, represent hydrogen or alkoxy of 1 to 4 carbon atoms, andX represent oxygen or sulfur,Their physiologically tolerated salts, process for preparing them. The compounds are active on the coronary circulation and are distinguished in particular by anti-arrhythmic action and may, therefore, be used in the treatment of disorders of the heart rhythm.

    摘要翻译： 其中R 1表示氢或具有1至6个碳原子的直链或支链烷基的通式I（I）的1,4-二氢-2H-异喹啉衍生物，R2代表低分子二烷基氨基烷基，其中两个烷基 的二烷基氨基与氮原子一起也可以形成5-，6-或7-元饱和环，其中一个碳原子可以被氧原子，硫原子或可被氢取代的另一个氮原子取代 ，C 1 -C 4 - 烷基或苯基，或者R 1和R 2一起可以形成含有1个氮原子的5或6元饱和环，R 3表示可以被卤素，硝基，氨基或氨磺酰基单取代或二取代的苯基 ，或各自含有1至4个碳原子的酰基氨基或烷基，或可以相同或不同的吡啶基R 4和R 5表示1至4个碳原子的氢或烷氧基，X代表氧或硫。它们的生理学可容忍的盐，方法 准备他们 这些化合物在冠状动脉循环中是有活性的，特别是通过抗心律失常作用来区分，因此可以用于治疗心律紊乱。

    Basically substituted 1,4-dihydro-2H-isoquinoline derivatives and process for preparing them
    8.
    发明授权
    Basically substituted 1,4-dihydro-2H-isoquinoline derivatives and process for preparing them 失效
    基本取代的1,4-二氢-2H-异喹啉衍生物及其制备方法

    公开(公告)号：US3980655A

    公开(公告)日：1976-09-14

    申请号：US515659

    申请日：1974-10-17

    申请人： Rudolf Kunstmann ,  Joachim Kaiser

    发明人： Rudolf Kunstmann ,  Joachim Kaiser

    IPC分类号： C07D217/22 ,  C07D401/04 ,  C07D471/10 ,  C07D217/24 ,  C07D401/06

    CPC分类号： C07D471/10 ,  C07D217/22 ,  Y10S514/821

    摘要： 1,4-Dihydro-2H-isoquinoline derivatives of the general formula I ##SPC1##in whichR.sup.1 represents hydrogen or straight chain or branched alkyl of 1 to 6 carbon atoms,R.sup.2 represents low molecular dialkylaminoalkyl, in which both alkyl groups of the dialkylamino group together with the nitrogen atom may also form a 5-, 6- or 7-membered saturated ring in which one carbon atom may be substituted by an oxygen atom, a sulfur atom or another nitrogen atom which may be substituted by hydrogen, C.sub.1 -C.sub.4 -alkyl or phenyl, or R.sup.1 and R.sup.2 together may form a 5- or 6-membered saturated ring containing 1 nitrogen atom,R.sup.3 represents phenyl which may be mono- or di-substituted by halogen, nitro, amino or sulfamoyl, or acylamino or alkyl each containing 1 to 4 carbon atoms, or pyridylR.sup.4 andR.sup.5, which may identical or different, represent hydrogen or alkoxy of 1 to 4 carbon atoms, andX represent oxygen or sulfur,Their physiologically tolerated salts, process for preparing them. The compounds are active on the coronary circulation and are distinguished in particular by an anti-arrhythmic action and may, therefore, be used in the treatment of disorders of the heart rhythm.

    摘要翻译： 通式Ⅰ的1,4-二氢-2H-异喹啉衍生物，其中R1代表氢或1至6个碳原子的直链或支链烷基，R2代表低分子二烷基氨基烷基，其中二烷基氨基的两个烷基与 氮原子也可以形成其中一个碳原子可以被氧原子，硫原子或可被氢取代的另一个氮原子取代的5-，6-或7-元饱和环，C 1 -C 4 - 烷基 或苯基，或R 1和R 2一起可以形成含有1个氮原子的5或6元饱和环，R 3表示可以被卤素，硝基，氨基或氨磺酰基单取代或二取代的苯基，或各自为酰基氨基或烷基 含有1至4个碳原子，或者可以相同或不同的吡啶基R 4和R 5表示1至4个碳原子的氢或烷氧基，X代表氧或硫。它们的生理学可容忍的盐，其制备方法。 该化合物在冠状动脉循环中是有活性的，特别是通过抗心律失常作用来区分，因此可用于治疗心律紊乱。

    Optical short-circuit insert and optical short-circuit plug
    9.
    发明授权
    Optical short-circuit insert and optical short-circuit plug 有权
    光学短路插头和光学短路插头

    公开(公告)号：US07025508B2

    公开(公告)日：2006-04-11

    申请号：US10651137

    申请日：2003-08-28

    申请人： Pia Kopf ,  Joachim Hahn ,  Rudolf Kunstmann ,  Miquel Seidenfaden

    发明人： Pia Kopf ,  Joachim Hahn ,  Rudolf Kunstmann ,  Miquel Seidenfaden

    IPC分类号： G02B6/36

    CPC分类号： G02B6/3827 ,  G02B6/3807 ,  G02B6/3893 ,  G02B6/403

    摘要： The invention provides an optical short-circuit insert for accommodation in a plug housing, with a plug region with two mutually parallel optical fiber ends of an optical fiber portion. A curved region of the optical fiber portion, intermediate optical fiber ends, is guided in an arc of 180 degrees. The optical fiber portion has a curved portion of a fiber consisting of multi-component glass with cladding or of a multi-conductor glass fiber with cladding, which is enveloped in a plastic carrier. An optical short-circuit plug with a plug housing enveloping a plug and a short-circuit insert capable of being pushed into it is also provided.

    摘要翻译： 本发明提供一种用于容纳在插头壳体中的光学短路插件，具有光纤部分的两个相互平行的光纤端部的插头区域。 光纤部分的中间光纤端部的弯曲区域以180度的弧度被引导。 光纤部分具有由多层玻璃与包层或具有包层的多导体玻璃纤维组成的纤维的弯曲部分，其被包封在塑料载体中。 还提供了具有包围插头的插头壳体和能够被推入其中的短路插入件的光学短路插头。