公开(公告)号：US5286858A

公开(公告)日：1994-02-15

申请号：US774945

申请日：1991-10-11

申请人： Minoru Moriwaki ,  Syuji Yuasa ,  Hiroyuki Kitani ,  Michio Terasawa

发明人： Minoru Moriwaki ,  Syuji Yuasa ,  Hiroyuki Kitani ,  Michio Terasawa

IPC分类号： A61K31/55 ,  A61K31/00 ,  A61K31/554 ,  A61P7/02 ,  A61P9/00 ,  A61P11/00 ,  A61P29/00 ,  A61P37/00 ,  A61P37/08 ,  A61P43/00 ,  C07D495/14 ,  C07D495/12

CPC分类号： C07D495/14

摘要： Stable crystals of an acid addition salt of an optically active thienotriazolodiazepine compound or its hydrate of the formula ##STR1## wherein R.sup.1 is hydrogen, R.sup.2 is 2-phenylethyl substituted by alkyl having 1 to 5 carbon atoms, 2-morpholinocarbonylethyl or alkyl having 6 to 12 carbon atoms, or R.sup.1 and R.sup.2 may combinedly form a saturated 5-membered ring having one substituent selected from the group consisting of morpholinomethyl, morpholinocarbonyl and N,N-dipropylcarbamoyl, R.sup.3 is halogen, alkyl having 1 to 5 carbon atoms or alkoxy having 1 to 5 carbon atoms, R.sup.4 is trifluoromethyl or alkyl having 1 to 5 carbon atoms, R.sup.5 is hydrogen or methyl, m is 1-2, and n is 0-2. The present invention provides optically active thienotriazolodiazepine compounds having strong PAF-antagonistic activity as markedly stable crystals which are excellent in crystalline property, permit purification by recrystallization, and have high chemical purity and optical purity, thereby rendering industrial large-scale synthesis attainable. In addition, crystallization thereof facilitates medicinal standardization and pharmaceutical formulation.

摘要翻译： 光学活性噻吩并三唑并噻嗪类化合物或其水合物（*化学结构*）（I）的酸加成盐的稳定晶体，其中R 1为氢，R 2为被具有1至5个碳原子的烷基取代的2-苯乙基， 吗啉代羰基乙基或具有6至12个碳原子的烷基，或者R 1和R 2可以组合形成具有一个选自吗啉代甲基，吗啉代羰基和N，N-二丙基氨基甲酰基的一个取代基的饱和五元环，R 3是卤素， 5个碳原子或具有1至5个碳原子的烷氧基，R4是三氟甲基或具有1-5个碳原子的烷基，R5是氢或甲基，m是1-2，n是0-2。 本发明提供具有优异结晶性的显色稳定结晶的具有强PAF拮抗作用的光学活性噻吩并三唑并氮杂化合物，可以通过重结晶进行纯化，化学纯度高，光学纯度高，从而可实现工业化的大规模合成。 此外，其结晶有助于药物标准化和药物制剂。

公开(公告)号：US5721231A

公开(公告)日：1998-02-24

申请号：US535913

申请日：1995-09-28

申请人： Minoru Moriwaki ,  Hiroyuki Kitani ,  Syuji Ehara ,  Hirotsugu Komatsu ,  Mariko Amano

发明人： Minoru Moriwaki ,  Hiroyuki Kitani ,  Syuji Ehara ,  Hirotsugu Komatsu ,  Mariko Amano

IPC分类号： C07D495/14 ,  A61K31/55

CPC分类号： C07D495/14

摘要： N-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno �3,2-f!�1,2,4!triazolo�4,3-a!�1,4!diazepin-6-yl )-N'- (2-methoxyphenyl)urea, optical isomers thereof and pharmaceutically acceptable salts thereof. The compounds of the present invention strongly and selectively inhibit the expression of VCAM-1 and have an inhibitory effect on leukocyte adhesion to vascular endothelial cells. Accordingly, the compounds of the present invention can be used as cell adhesion inhibitors for prophylaxis or treatment of various diseases in which cell adhesion is involved in the onset and progress thereof.

摘要翻译： N-（4-（4-氯苯基）-2,3,9-三甲基-6H-噻吩并〔3,2-f〕〔1,2,4〕三唑并〔4,3-a〕〔1,4〕二氮杂 -6-基）-N'-（2-甲氧基苯基）脲，其旋光异构体和其药学上可接受的盐。 本发明化合物强烈和选择性地抑制VCAM-1的表达，并且对白细胞对血管内皮细胞的粘附具有抑制作用。 因此，本发明的化合物可以用作细胞粘附抑制剂，用于预防或治疗其起因和进展中涉及细胞粘附的各种疾病。

公开(公告)号：US06305170B1

公开(公告)日：2001-10-23

申请号：US09695716

申请日：2000-10-25

申请人： Hiroyuki Kitani ,  Yoshinori Nakagawa

发明人： Hiroyuki Kitani ,  Yoshinori Nakagawa

IPC分类号： F02G300

CPC分类号： F02G5/02 ,  Y02E20/14 ,  Y02T10/166

摘要： An exhaust gas released from the exhaust gas heat exchanger 9 is conveyed into the inlet of a bend 32 communicated to a silencer 31. The exhaust gas mixed with the condensed water is upwardly passed as a mixture fluid through a passage 322 and forced into a first expansion chamber 323. The mixture fluid is separated into the exhaust gas and the condensed water in the chamber 323 and conveyed downwardly in a passage 324 provided with a second expansion chamber 325. While the exhaust gas is forced upwardly from the lower end of the silencer 31, the condensed water is discharged downwardly. The condensed water is conveyed in the drain passage of a waster water trap and released to the outside.

摘要翻译： 从排气热交换器9排出的废气被输送到与消声器31连通的弯曲部32的入口。与冷凝水混合的废气作为混合流体向上通过通道322，并被迫进入第一 混合流体被分离成排气和室323中的冷凝水，并在设有第二膨胀室325的通道324中向下输送。当排气从消音器的下端向上压 如图31所示，冷凝水向下排出。 冷凝水在废水捕集器的排水通道中传送并释放到外部。

公开(公告)号：US20060025025A1

公开(公告)日：2006-02-02

申请号：US11188144

申请日：2005-07-22

申请人： Hiroyuki Kitani ,  Kazumi Miyashita ,  Shigeo Terada ,  Tadafumi Hirose

发明人： Hiroyuki Kitani ,  Kazumi Miyashita ,  Shigeo Terada ,  Tadafumi Hirose

IPC分类号： B60L11/02

CPC分类号： B63H11/107 ,  B63H20/02 ,  B63H21/20 ,  B63H23/30 ,  B63H2021/205 ,  F02N11/00 ,  Y02T70/5236

摘要： An outboard motor is equipped with a centrifugal clutch located between the crankshaft of an engine and a rotor of an electric motor for, when the engine operates, transmitting its output to through the rotor to a propeller, and with a motor output transmission mechanism for, when the engine does not operate, transmitting the output of the motor to the crankshaft. The engine can therefore be started by the motor used to drive the propeller. As a result, there is no need to install a separate electric motor for engine starting, so that starting of the engine by electric power can be made possible with minimum increase in the size and cost of the outboard motor.

摘要翻译： 舷外马达配备有位于发动机的曲轴和电动机的转子之间的离心式离合器，当发动机运转时，将其输出通过转子传递到螺旋桨，并且具有马达输出传动机构， 当发动机不工作时，将马达的输出传递到曲轴。 因此，发动机可以由用于驱动螺旋桨的电机启动。 因此，不需要安装用于发动机起动的单独的电动马达，从而能够以最小的舷外马达的尺寸和成本来增加发动机的电力起动。

公开(公告)号：US07300322B2

公开(公告)日：2007-11-27

申请号：US11188144

申请日：2005-07-22

申请人： Hiroyuki Kitani ,  Kazumi Miyashita ,  Shigeo Terada ,  Tadafumi Hirose

发明人： Hiroyuki Kitani ,  Kazumi Miyashita ,  Shigeo Terada ,  Tadafumi Hirose

IPC分类号： B60L11/00 ,  B63H21/20

CPC分类号： B63H11/107 ,  B63H20/02 ,  B63H21/20 ,  B63H23/30 ,  B63H2021/205 ,  F02N11/00 ,  Y02T70/5236

摘要： An outboard motor is equipped with a centrifugal clutch located between the crankshaft of an engine and a rotor of an electric motor for, when the engine operates, transmitting its output to through the rotor to a propeller, and with a motor output transmission mechanism for, when the engine does not operate, transmitting the output of the motor to the crankshaft. The engine can therefore be started by the motor used to drive the propeller. As a result, there is no need to install a separate electric motor for engine starting, so that starting of the engine by electric power can be made possible with minimum increase in the size and cost of the outboard motor.

摘要翻译： 舷外马达配备有位于发动机的曲轴和电动机的转子之间的离心式离合器，当发动机运转时，将其输出通过转子传递到螺旋桨，并且具有马达输出传动机构， 当发动机不工作时，将马达的输出传递到曲轴。 因此，发动机可以由用于驱动螺旋桨的电机启动。 因此，不需要安装用于发动机起动的单独的电动马达，从而能够以最小的舷外马达的尺寸和成本来增加发动机的电力起动。

公开(公告)号：US06324849B1

公开(公告)日：2001-12-04

申请号：US09691834

申请日：2000-10-18

申请人： Kazuhiro Togawa ,  Hiroyuki Kitani

发明人： Kazuhiro Togawa ,  Hiroyuki Kitani

IPC分类号： F02G300

CPC分类号： F02G5/04 ,  Y02E20/14 ,  Y02T10/166

摘要： An engine cooling unit and an exhaust gas heat exchanger 9 for use with the exhaust gas from an engine are connected with a circulation path 12 for circulating a heat transfer medium. The output of the circulation path 12 is connected via a conduit 18 to an output heat exchanger installed in e.g. a hot water storage tank 17. The exhaust gas heat exchanger 9 is disposed across the circulation path 12 at the upstream side of the engine cooling unit of the engine 2. The heat transfer medium introduced into the exhaust gas heat exchanger 9 is set to a lower temperature enough to maintain the temperature of vapor in the exhaust gas of which heat is transferred to the heat transfer medium lower than the dew point. The heat transfer medium after drawing generic heat from the exhaust gas and receiving its condensation heat in the exhaust gas heat exchanger 9 is passed to the engine cooling unit 6A where it draws more heat. Accordingly, the heat generated by the engine 2 can be recovered at a higher efficiency.

摘要翻译： 用于与发动机的排气一起使用的发动机冷却单元和排气热交换器9与用于循环传热介质的循环路径12连接。 循环路径12的输出通过导管18连接到例如安装在输出侧的输出热交换器。 排气热交换器9在发动机2的发动机冷却单元的上游侧配置在循环路径12的两侧。导入排气热交换器9的传热介质被设定为 较低的温度足以将热量的废气中的蒸气的温度保持在低于露点的传热介质中。 在从排气中抽出通用热量并在排气热交换器9中接收其冷凝热之后的传热介质被传递到发动机冷却单元6A，在那里其吸收更多的热量。 因此，能够以更高的效率回收由发动机2产生的热量。