New compound
    8.
    发明申请
    New compound 审中-公开
    新化合物

    公开(公告)号:US20050004014A1

    公开(公告)日:2005-01-06

    申请号:US10860508

    申请日:2004-06-04

    CPC分类号: C07K7/56 A61K38/00

    摘要: This invention relates to new lipopeptide compound represented by the following general formula (I): wherein R1, R2, R3, R4 and R5 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.

    摘要翻译: 本发明涉及由以下通式(I)表示的新的脂肽化合物:其中R 1,R 2,R 3,R 4和R 5如说明书中所定义或 其具有抗微生物活性(特别是抗真菌活性),对β-1,3-葡聚糖合酶的抑制活性,其制备方法,包含其的药物组合物,以及预防和/或治疗方法 的感染性疾病,包括人或动物中的卡氏肺囊虫感染(例如肺孢子虫肺炎)。

    APPARATUS AND METHOD OF KNITTING MATERIAL INTO A CIRCULAR TUBE

    公开(公告)号:US20200255990A1

    公开(公告)日:2020-08-13

    申请号:US16274208

    申请日:2019-02-12

    IPC分类号: D04B15/88 D04B15/32

    摘要: The field of the present invention relates, in general, to apparatus and methods of knitting a material into a tubular form, where the length of such tubular form is not dictated by conventional distances between the knitting areas and the catch basins of integrated machines. In short, this invention increases the distal relationship between the needle-equipped element, which performs the knitting function, and the basin that catches the resulting tubular form of the material. The basin rotates synchronized with the rotation of the resulting tubular form. The separation facilitates the continuous production of a length of the resulting tubular form of the material. The tubular form thus can be longer than such length where, as taught in the prior art, the catch basin is fixed—as part of integrated machines—in close proximity with the element that performs the knitting. As an inventive method, the steps include (A) feeding such material into the proximity of a needle-equipped element; (B) knitting such material with such needle-equipped element to produce such resulting tubular form; (C) catching such resulting tubular form in a basin that is physically disconnected from the needle-equipped element and distanced therefrom to produce a desirably longer length of the resulting tubular form; and (D) electronically controlling such feeding step, such knitting step, and such catching step (synchronizing the catching with the rotation of resulting tubular form), whereby the rates of the feeding, knitting and catching produce such resulting tubular form that is unbuckled.