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1.发明申请DROPLET DISPENSATION FROM A RESERVOIR WITH REDUCTION IN UNCONTROLLED ELECTROSTATIC CHARGE 有权从不受控制的静电电荷中减少的储层中的液滴分配公开(公告)号：US20060244778A1
公开(公告)日：2006-11-02
申请号：US11481341
申请日：2006-07-03
申请人： Mitchell Mutz , David Lee , George McLendon
发明人： Mitchell Mutz , David Lee , George McLendon
IPC分类号： B41J2/015
CPC分类号： B41J2/04511 , B41J2/04526 , B41J2/04575 , B41J2/14008
摘要： Devices and methods are provided for reducing the uncontrolled electrostatic charges that can alter the volume and/or trajectory of a droplet, which is typically ejected through the application of focused acoustic radiation. Also provided are reservoirs and substrates, e.g., well plates formed from a material that is at least partially nonmetallic or polymeric and either has an electrical resistivity of no more than about 1011 ohm-cm, has a surface electrical resistivity of no more than about 1012 ohm/sq, or both.
摘要翻译： 提供了用于减少不受控制的静电电荷的装置和方法，所述静电电荷可以改变液滴的体积和/或轨迹，所述液滴和/或轨迹通常通过聚焦声辐射的应用而被喷射。 还提供了储存器和基底，例如，由至少部分非金属或聚合物材料形成的并且具有不大于约10欧姆 - 厘米的电阻率的材料形成的孔板具有表面 电阻率不超过约10欧姆/平方或两者。
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2.发明申请Droplet dispensation from a reservoir with reduction in uncontrolled electrostatic charge 有权来自储存器的液滴分配，减少不受控制的静电电荷公开(公告)号：US20070153049A1
公开(公告)日：2007-07-05
申请号：US11714391
申请日：2007-03-05
申请人： Mitchell Mutz , David Lee , George McLendon
发明人： Mitchell Mutz , David Lee , George McLendon
IPC分类号： B41J2/015
CPC分类号： B41J2/04511 , B41J2/04526 , B41J2/04575 , B41J2/14008
摘要： Devices and methods are provided for reducing the uncontrolled electrostatic charges that can alter the volume and/or trajectory of a droplet, which is typically ejected through the application of focused acoustic radiation. Also provided are reservoirs and substrates, e.g., well plates formed from a material that is at least partially nonmetallic or polymeric and either has an electrical resistivity of no more than about 1011 ohm-cm, has a surface electrical resistivity of no more than about 1012 ohm/sq, or both.
摘要翻译： 提供了用于减少不受控制的静电电荷的装置和方法，所述静电电荷可以改变液滴的体积和/或轨迹，所述液滴和/或轨迹通常通过聚焦声辐射的应用而被喷射。 还提供了储存器和基底，例如，由至少部分非金属或聚合物材料形成的并且具有不大于约10欧姆 - 厘米的电阻率的材料形成的孔板具有表面 电阻率不超过约10欧姆/平方或两者。
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公开(公告)号：US20210020026A1
公开(公告)日：2021-01-21
申请号：US16679231
申请日：2019-11-10
申请人： George McLendon , Alex Dzeda , Joshua Phipps , Shannon Stearman
发明人： George McLendon , Alex Dzeda , Joshua Phipps , Shannon Stearman
摘要： This document presents a system and method for analyzing migraine related sensor and diary data to permit the prediction of migraine headaches for individuals. A mobile device is adapted to collect and transmit to a server data content from sensors associated with the mobile device and self-reported data content indicative of contemporaneous environmental conditions and individual physical conditions when the individual is suffering from a migraine headache. The server uses the data content to develop predictive metrics indicative of a correlation between the migraine events and the sensor data. The predictive metrics will provide an alert to a designated individual if it is likely the individual will experience a migraine within a future time period.
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公开(公告)号：US20100261914A1
公开(公告)日：2010-10-14
申请号：US12761737
申请日：2010-04-16
申请人： Yigong Shi , Martin F. Semmelhack , Martin Case , Philip A. Albiniak , George McLendon , Rachael A. Kipp , Aislyn D. Wist
发明人： Yigong Shi , Martin F. Semmelhack , Martin Case , Philip A. Albiniak , George McLendon , Rachael A. Kipp , Aislyn D. Wist
IPC分类号： C07D207/06
CPC分类号： C07K5/06026 , A61K38/00 , C07K5/0821 , C07K5/1008 , G01N33/574
摘要： Compounds that bind cellular IAPs (inhibitor of apoptosis proteins) are disclosed. The compounds are mimetics of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABOLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these compounds for therapeutic, diagnostic and assay purposes.
摘要翻译： 公开了结合细胞IAP（凋亡蛋白的抑制剂）的化合物。 这些化合物是IAP结合蛋白的N-末端四肽的模拟物，例如与IAP的特定表面凹槽相互作用的Smac / DIABOLO，Hid，Grim和Reaper。 还公开了使用这些化合物用于治疗，诊断和测定目的的方法。
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5.发明授权Droplet dispensation from a reservoir with reduction in uncontrolled electrostatic charge 有权来自储存器的液滴分配，减少不受控制的静电电荷公开(公告)号：US07070260B2
公开(公告)日：2006-07-04
申请号：US10340557
申请日：2003-01-09
IPC分类号： B41J2/06
CPC分类号： B41J2/04511 , B41J2/04526 , B41J2/04575 , B41J2/14008
摘要： Devices and methods are provided for reducing the uncontrolled electrostatic charges that can alter the volume and/or trajectory of a droplet, which is typically ejected through the application of focused acoustic radiation. Also provided are reservoirs and substrates, e.g., well plates formed from a material that is at least partially nonmetallic or polymeric and either has an electrical resistivity of no more than about 1011 ohm-cm, has a surface electrical resistivity of no more than about 1012 ohm/sq, or both.
摘要翻译： 提供了用于减少不受控制的静电电荷的装置和方法，所述静电电荷可以改变液滴的体积和/或轨迹，所述液滴和/或轨迹通常通过聚焦声辐射的应用而被喷射。 还提供了储存器和基底，例如，由至少部分非金属或聚合物材料形成的并且具有不大于约10欧姆 - 厘米的电阻率的材料形成的孔板具有表面 电阻率不超过约10欧姆/平方或两者。
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6.发明申请Iap binding peptides and assays for identifying compounds that bind iap 审中-公开Iap结合肽和用于鉴定结合iap的化合物的测定公开(公告)号：US20050176649A1
公开(公告)日：2005-08-11
申请号：US10478521
申请日：2002-05-31
申请人： George McLendon , Rachel Kipp , Martin Case , Yigong Shi
发明人： George McLendon , Rachel Kipp , Martin Case , Yigong Shi
IPC分类号： G01N33/566 , A61K38/05 , C07K5/06 , C07K5/103 , G01N21/78 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/533 , G01N33/58 , G01N33/68
CPC分类号： G01N33/68 , C07K5/1008 , G01N33/533 , G01N33/6845
摘要： Assays are disclosed for identifying peptides and peptidomimetics for promoting apotosis in cells, through a pathway involving the Inhibitor of Apoptosis Proteins (IAPs), exemplified by XIAP, and the mitochondrial protein Smac/DIABOLO (hereinafter Smac) and homologs thereof. Also disclosed are IAP-binding peptides and peptidomimetics identified through the use of the assay.
摘要翻译： 通过涉及由XIAP例证的细胞凋亡蛋白抑制剂（IAP）和线粒体蛋白Smac / DIABOLO（以下称Smac）及其同系物的途径，公开了用于鉴定用于促进细胞凋亡的肽和肽模拟物的测定。 还公开了通过使用测定法鉴定的IAP结合肽和肽模拟物。
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公开(公告)号：US07718600B2
公开(公告)日：2010-05-18
申请号：US10521723
申请日：2003-07-15
申请人： George McLendon , Rachael A. Kipp , Martin Case , Yigong Shi , Martin F. Semmelhack , Philip A. Albiniak , Aislyn D. Wist
发明人： George McLendon , Rachael A. Kipp , Martin Case , Yigong Shi , Martin F. Semmelhack , Philip A. Albiniak , Aislyn D. Wist
CPC分类号： C07K5/06026 , A61K38/00 , C07K5/0821 , C07K5/1008 , G01N33/574
摘要： Compounds that bind cellular IAPs (inhibitor of apoptosis proteins) are disclosed. The compounds are mimetics of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABOLO, IIid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these compounds for therapeutic, diagnostic and assay purposes.
摘要翻译： 公开了结合细胞IAP（凋亡蛋白的抑制剂）的化合物。 这些化合物是IAP结合蛋白的N-末端四肽的模拟物，例如与IAP的特定表面凹槽相互作用的Smac / DIABOLO，IIid，Grim和Reaper。 还公开了使用这些化合物用于治疗，诊断和测定目的的方法。
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8.发明授权Droplet dispensation from a reservoir with reduction in uncontrolled electrostatic charge 有权来自储存器的液滴分配，减少不受控制的静电电荷公开(公告)号：US07481511B2
公开(公告)日：2009-01-27
申请号：US11714391
申请日：2007-03-05
IPC分类号： B41J2/015
CPC分类号： B41J2/04511 , B41J2/04526 , B41J2/04575 , B41J2/14008
摘要： Devices and methods are provided for reducing the uncontrolled electrostatic charges that can alter the volume and/or trajectory of a droplet, which is typically ejected through the application of focused acoustic radiation. Also provided are reservoirs and substrates, e.g., well plates formed from a material that is at least partially nonmetallic or polymeric and either has an electrical resistivity of no more than about 1011 ohm-cm, has a surface electrical resistivity of no more than about 1012 ohm/sq, or both.
摘要翻译： 提供了用于减少不受控制的静电电荷的装置和方法，所述静电电荷可以改变液滴的体积和/或轨迹，所述液滴和/或轨迹通常通过聚焦声辐射的应用而被喷射。 还提供了储存器和基板，例如由至少部分非金属或聚合物材料形成的并且具有不超过约1011欧姆 - 厘米的电阻率的材料形成的孔板，其表面电阻率不超过约1012 欧姆/平方或两者。
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公开(公告)号：US20070032437A1
公开(公告)日：2007-02-08
申请号：US10521723
申请日：2003-07-15
申请人： Yigong Shi , Martin Semmelhack , Martin Case , Philip Albiniak , George McLendon , Rachael Kipp , Aislyn Wost
发明人： Yigong Shi , Martin Semmelhack , Martin Case , Philip Albiniak , George McLendon , Rachael Kipp , Aislyn Wost
IPC分类号： A61K38/04 , A61K31/401 , C07K5/04 , C12Q1/37
CPC分类号： C07K5/06026 , A61K38/00 , C07K5/0821 , C07K5/1008 , G01N33/574
摘要： Compounds that bind cellular IAPs (inhibitor of apoptosis proteins) are disclosed. The compounds are mimetics of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABOLO, IIid. Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these compounds for therapeutic, diagnostic and assay purposes.
摘要翻译： 公开了结合细胞IAP（凋亡蛋白的抑制剂）的化合物。 这些化合物是IAP结合蛋白的N-末端四肽的模拟物，如Smac / DIABOLO，IIid。 Grim和Reaper与IAP的特定表面槽相互作用。 还公开了使用这些化合物用于治疗，诊断和测定目的的方法。
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10.发明授权公开(公告)号：US07185969B2
公开(公告)日：2007-03-06
申请号：US11481341
申请日：2006-07-03
IPC分类号： B41J2/015
CPC分类号： B41J2/04511 , B41J2/04526 , B41J2/04575 , B41J2/14008
摘要： Devices and methods are provided for reducing the uncontrolled electrostatic charges that can alter the volume and/or trajectory of a droplet, which is typically ejected through the application of focused acoustic radiation. Also provided are reservoirs and substrates, e.g., well plates formed from a material that is at least partially nonmetallic or polymeric and either has an electrical resistivity of no more than about 1011 ohm-cm, has a surface electrical resistivity of no more than about 1012 ohm/sq, or both.
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