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公开(公告)号：US20060021071A1
公开(公告)日：2006-01-26
申请号：US10959309
申请日：2004-10-07
申请人： Mitsuo Satoh , Shigeru Iida , Katsuhiro Mori , Miho Urakubo , Reiko Kamochi , Kazuya Yamano
发明人： Mitsuo Satoh , Shigeru Iida , Katsuhiro Mori , Miho Urakubo , Reiko Kamochi , Kazuya Yamano
IPC分类号： A01K67/027 , C07H21/04 , C12P21/06 , A61K39/395 , A01H1/00 , C12N5/06 , C12N5/04
CPC分类号： C12N9/88 , A01K2217/075 , C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/732 , C12N2510/02
摘要： The present invention provides a cell capable of controlling the sugar chain structure of a glycoprotein which is a producing protein, that is, a cell capable of producing a glycoprotein having high physiological activity; a process for producing a glycoprotein using the cell; a glycoprotein produced by the process; and use thereof.
摘要翻译： 本发明提供能够控制作为产生蛋白质的糖蛋白的糖链结构的细胞，即能够产生具有高生理活性的糖蛋白的细胞; 使用该细胞产生糖蛋白的方法; 通过该过程产生的糖蛋白; 及其用途。
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公开(公告)号：US20050216958A1
公开(公告)日：2005-09-29
申请号：US11127173
申请日：2005-05-12
申请人： Naoko Yamane , Mitsuo Satoh , Katsuhiro Mori , Kazuya Yamano
发明人： Naoko Yamane , Mitsuo Satoh , Katsuhiro Mori , Kazuya Yamano
IPC分类号： A61P9/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/00 , C07K16/28 , C07K16/30 , C12N9/10 , C12P21/08 , A01K67/027 , A01H1/00 , C12N5/04 , C12N5/06 , C12N15/82
CPC分类号： C07K16/3084 , A01K2217/075 , C07K16/2866 , C07K16/2896 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C12N9/1051 , C12N2510/00 , C12Y204/01068
摘要： A cell in which genome is modified so as to have a more decreased or deleted activity of an enzyme relating to modification of a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in a complex N-glycoside-linked sugar chain than its parent cell, and a process for producing an antibody composition using the cell.
摘要翻译： 其中基因组被修饰以具有与糖链修饰相关的酶的更多减少或缺失的活性的细胞，其中岩藻糖的1位通过α通过还原末端结合到N-乙酰氨基葡萄糖的6-位上 在其复合N-糖苷连接的糖链中比其亲本细胞，以及使用该细胞产生抗体组合物的方法。
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3.发明授权公开(公告)号：US07858091B2
公开(公告)日：2010-12-28
申请号：US12013293
申请日：2008-01-11
申请人： Kazuya Yamano , Susumu Sekine , Mitsuo Satoh , Toshio Ota , Akiko Furuya , Kenji Shibata , Yuki Kobayashi , Miho Takebayashi , Yusuke Nakamura , Sumio Sugano
发明人： Kazuya Yamano , Susumu Sekine , Mitsuo Satoh , Toshio Ota , Akiko Furuya , Kenji Shibata , Yuki Kobayashi , Miho Takebayashi , Yusuke Nakamura , Sumio Sugano
IPC分类号： A61K39/395 , C12N5/12 , G01N33/53
CPC分类号： C07K16/26 , A61K38/00 , A61K2039/505 , C07K14/4743 , C07K16/18 , C07K2317/34
摘要： Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.
摘要翻译： 使用本发明的蛋白质，编码蛋白质的DNA和识别蛋白质的抗体，与本发明的新型胰岛素样生长因子结合蛋白相关的疾病的检测方法以及诊断试剂，预防剂和治疗剂 可以提供与本发明的蛋白质相关的疾病的药剂。
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公开(公告)号：US20060078990A1
公开(公告)日：2006-04-13
申请号：US11287324
申请日：2005-11-28
申请人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
发明人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
IPC分类号： C12N5/06
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
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公开(公告)号：US20060063254A1
公开(公告)日：2006-03-23
申请号：US11218473
申请日：2005-09-06
申请人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
发明人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
IPC分类号： A61K39/395 , C12N5/06 , C07K16/44
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
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公开(公告)号：US08329443B2
公开(公告)日：2012-12-11
申请号：US13102565
申请日：2011-05-06
申请人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
发明人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
摘要翻译： 本发明涉及用于生产抗体分子的细胞，例如可用于具有高抗体依赖性细胞介导的细胞毒活性的各种疾病的抗体，抗体片段和具有抗体Fc区的融合蛋白，或 类似物，使用该细胞的抗体组合物的制备方法，抗体组合物及其用途。
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7.发明授权Antibody composition-producing cell with inactivated A-1,6-fusocyltransferase 有权具有灭活的A-1,6-岩藻糖基转移酶的抗体组合物产生细胞公开(公告)号：US08067232B2
公开(公告)日：2011-11-29
申请号：US12048343
申请日：2008-03-14
申请人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
发明人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
摘要翻译： 本发明涉及用于生产抗体分子的细胞，例如可用于具有高抗体依赖性细胞介导的细胞毒活性的各种疾病的抗体，抗体片段和具有抗体Fc区的融合蛋白，或 类似物，使用该细胞的抗体组合物的制备方法，抗体组合物及其用途。
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公开(公告)号：US20110250643A1
公开(公告)日：2011-10-13
申请号：US13102565
申请日：2011-05-06
申请人： Yutaka KANDA , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
发明人： Yutaka KANDA , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
摘要翻译： 本发明涉及用于生产抗体分子的细胞，例如可用于具有高抗体依赖性细胞介导的细胞毒活性的各种疾病的抗体，抗体片段和具有抗体Fc区的融合蛋白，或 类似物，使用该细胞的抗体组合物的制备方法，抗体组合物及其用途。
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公开(公告)号：US08367407B2
公开(公告)日：2013-02-05
申请号：US12409587
申请日：2009-03-24
申请人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
发明人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell and mammal in which GDP-mannose 4,6-dehydratase is knocked-out. The cell and mammal are useful for the production of an antibody molecule having high antibody-dependent cell-mediated cytotoxic activity, such as an antibody useful for treating various diseases. The cell and mammal are also useful for the production of a fragment of the antibody, and a fusion protein having the Fc region of the antibody.
摘要翻译： 本发明涉及其中GDP-甘露糖4,6-脱水酶被淘汰的细胞和哺乳动物。 细胞和哺乳动物可用于生产具有高抗体依赖性细胞介导的细胞毒活性的抗体分子，例如可用于治疗各种疾病的抗体。 细胞和哺乳动物也可用于产生抗体的片段，以及具有抗体Fc区的融合蛋白。
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公开(公告)号：US20090191592A1
公开(公告)日：2009-07-30
申请号：US12351635
申请日：2009-01-09
申请人： Yutaka KANDA , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
发明人： Yutaka KANDA , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
IPC分类号： C12P21/08
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
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