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1.发明授权公开(公告)号：US07858091B2
公开(公告)日：2010-12-28
申请号：US12013293
申请日：2008-01-11
申请人： Kazuya Yamano , Susumu Sekine , Mitsuo Satoh , Toshio Ota , Akiko Furuya , Kenji Shibata , Yuki Kobayashi , Miho Takebayashi , Yusuke Nakamura , Sumio Sugano
发明人： Kazuya Yamano , Susumu Sekine , Mitsuo Satoh , Toshio Ota , Akiko Furuya , Kenji Shibata , Yuki Kobayashi , Miho Takebayashi , Yusuke Nakamura , Sumio Sugano
IPC分类号： A61K39/395 , C12N5/12 , G01N33/53
CPC分类号： C07K16/26 , A61K38/00 , A61K2039/505 , C07K14/4743 , C07K16/18 , C07K2317/34
摘要： Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.
摘要翻译： 使用本发明的蛋白质，编码蛋白质的DNA和识别蛋白质的抗体，与本发明的新型胰岛素样生长因子结合蛋白相关的疾病的检测方法以及诊断试剂，预防剂和治疗剂 可以提供与本发明的蛋白质相关的疾病的药剂。
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公开(公告)号：US20090258007A1
公开(公告)日：2009-10-15
申请号：US11628745
申请日：2005-06-07
申请人： Atsushi Ochiai , Norihiko Shiraishi , Yoko Kato , Toshio Ota , Susumu Sekine , Kenya Shitara , Akiko Furuya , So Ohta , Emi Hosaka , Yuka Sasaki
发明人： Atsushi Ochiai , Norihiko Shiraishi , Yoko Kato , Toshio Ota , Susumu Sekine , Kenya Shitara , Akiko Furuya , So Ohta , Emi Hosaka , Yuka Sasaki
IPC分类号： A61K39/395 , C07K16/00 , C12N5/12 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00 , G01N33/53 , C12Q1/68 , A61P35/00
CPC分类号： G01N33/57492 , C07K16/28 , C07K2317/732 , C07K2317/734
摘要： The present invention provides an antibody which specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by PERP (p53 apoptosis effector related to PMP-22) gene and binds to the extracellular region. The antibody of the present invention is useful for treatment of various diseases which highly expresses a polypeptide encoded by the PERP gene. Also, a polypeptide encoded by the PERP gene or a cell expressing the polypeptide can be specifically detected by an immunological method using the antibody, so that the antibody is useful for diagnosis of various diseases related to PERP.
摘要翻译： 本发明提供一种特异性识别由PERP编码的多肽的细胞外区域的三维结构的抗体（与PMP-22相关的p53凋亡效应）并结合到细胞外区域。 本发明的抗体可用于治疗高表达由PERP基因编码的多肽的各种疾病。 此外，可以通过使用抗体的免疫学方法特异性检测由PERP基因编码的多肽或表达多肽的细胞，使得该抗体可用于诊断与PERP相关的各种疾病。
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公开(公告)号：US20080044425A1
公开(公告)日：2008-02-21
申请号：US11829510
申请日：2007-07-27
申请人： Hiromasa Miyaji , Motoko Haruoka , Hiroyuki Nagata , Toshio Ota , Ayako Kawabata , Sumio Sugano , Yusuke Nakamura
发明人： Hiromasa Miyaji , Motoko Haruoka , Hiroyuki Nagata , Toshio Ota , Ayako Kawabata , Sumio Sugano , Yusuke Nakamura
IPC分类号： A61K39/395 , A61P1/00 , A61P11/06 , A61P17/00 , A61P19/02 , A61P25/16 , A61P25/28 , A61P3/10 , A61P35/00 , C07H21/04 , C07K14/435 , C07K16/40 , C12N1/00 , C12N1/21 , C12N5/04 , C12N5/06 , C12P21/06 , G01N33/53
CPC分类号： C12N9/16 , A61K38/00 , A61K2039/505 , C07K16/40 , C12N9/20
摘要： The present invention relates to a novel phospholipase A2 polypeptide, DNA encoding the polypeptide, a vector comprising the DNA, a transformant transformed with the vector, and a process for producing the phospholipase A2 polypeptide. The present invention also relates to a method of utilizing the polypeptide, e.g., a method of screening for a compound having agonist or antagonist activity by using the polypeptide or an antibody to the polypeptide, and a pharmaceutical comprising the polypeptide or an antibody to the polypeptide. The present invention further relates to a polypeptide inhibiting the phospholipase A2 activity of a phospholipase A2 polypeptide (hereinafter referred to as inhibitor polypeptide), DNA encoding the inhibitor polypeptide, a vector comprising the DNA encoding the inhibitor polypeptide, a transformant transformed with the vector, a pharmaceutical comprising the inhibitor polypeptide, and a process for producing the inhibitor polypeptide.
摘要翻译： 本发明涉及新的磷脂酶A 2 N多肽，编码多肽的DNA，包含DNA的载体，用载体转化的转化体，以及产生磷脂酶A 2的方法， / SUB多肽。 本发明还涉及一种利用该多肽的方法，例如通过使用该多肽或该多肽的抗体筛选具有激动剂或拮抗剂活性的化合物的方法，以及包含该多肽或该多肽的抗体的药物 。 本发明还涉及抑制磷脂酶A 2 N 2多肽（以下称为抑制剂多肽）的磷脂酶A 2活性的多肽，编码抑制剂多肽的DNA， 包含编码抑制剂多肽的DNA的载体，用载体转化的转化体，包含抑制剂多肽的药物，以及产生抑制剂多肽的方法。
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4.发明授权公开(公告)号：US07279558B2
公开(公告)日：2007-10-09
申请号：US11051410
申请日：2005-02-04
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译： 使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。 使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。 由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。 证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。 该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。
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公开(公告)号：US07217800B2
公开(公告)日：2007-05-15
申请号：US10932004
申请日：2004-09-02
申请人： Jun Takasaki , Masazumi Kamohara , Mitsuyuki Matsumoto , Tetsu Saito , Tohru Sugimoto , Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Kawai
发明人： Jun Takasaki , Masazumi Kamohara , Mitsuyuki Matsumoto , Tetsu Saito , Tohru Sugimoto , Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Kawai
IPC分类号： C07K16/28
CPC分类号： C07K14/705 , A61K38/00 , G01N33/6893 , G01N2500/00 , G01N2500/04
摘要： A cDNA encoding a novel LTC4 receptor has been isolated. Provision of the novel protein, an LTC4 receptor, enabled binding experiments using the LTC4. By screening for compounds that modulate LTC4 receptor activity based on these binding experiments, development of drugs targeting the LTC4 receptor becomes possible.
摘要翻译： 已经分离了编码新型LTC4受体的cDNA。 提供新的蛋白质，LTC4受体，能够使用LTC4N4进行结合实验。 通过基于这些结合实验筛选调节LTC4受体活性的化合物，开发靶向LTC4受体的药物成为可能。
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公开(公告)号：US20070082345A1
公开(公告)日：2007-04-12
申请号：US11429594
申请日：2006-05-08
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Kawai , Tomoyasu Sugiyama , Koji Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Kawai , Tomoyasu Sugiyama , Koji Hayashi
CPC分类号： C07K14/505 , C07K14/47
摘要： Novel human secretory proteins or membrane proteins, and full length cDNAs encoding the proteins are provided. 173 kinds of novel proteins and polynucleotides encoding these proteins have been isolated. The proteins of the present invention are useful as candidates for medicines or as target molecules for developing medicines. The polynucleotides of the present invention are used to produce these proteins.
摘要翻译： 提供新的人类分泌蛋白或膜蛋白，以及编码蛋白质的全长cDNA。 已经分离了173种新型蛋白质和编码这些蛋白质的多核苷酸。 本发明的蛋白质可用作药物的候选物或用作开发药物的靶分子。 本发明的多核苷酸用于制备这些蛋白质。
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公开(公告)号：US07129338B1
公开(公告)日：2006-10-31
申请号：US10305278
申请日：2002-11-27
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Kawai , Tomoyasu Sugiyama , Koji Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Kawai , Tomoyasu Sugiyama , Koji Hayashi
IPC分类号： C07H19/167 , C07H19/173
CPC分类号： C07K14/47 , C07K14/505
摘要： Human cDNA encoding a secretory or membrane protein useful as a candidate for developing medicine or as a target molecule for developing medicine. The expression level of the polynucleotide of the present invention increased in NT2 cells after retinoic acid-treatment. Accordingly, this cDNA is associated neurological disease.
摘要翻译： 编码分泌蛋白或膜蛋白的人类cDNA可用作开发药物或用作开发药物的靶分子。 在视黄酸处理后，本发明的多核苷酸的表达量在NT2细胞中增加。 因此，该cDNA与神经系统疾病相关。
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公开(公告)号：US06960435B1
公开(公告)日：2005-11-01
申请号：US10030269
申请日：2000-07-06
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Hio , Mayako Yamazaki , Susumu Satoh , Hiroyuki Arakawa , Masahiko Morita
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Hio , Mayako Yamazaki , Susumu Satoh , Hiroyuki Arakawa , Masahiko Morita
CPC分类号： C07K14/4711
摘要： The present invention provides: proteins suppressing or promoting the aggregation or deposition of amyloid-β protein; polynucleotides encoding the proteins; a method for screening a compound suppressing or promoting the aggregation or deposition of amyloid-β protein; and therapeutic agents for treating or preventing Alzheimer's diseases comprising a compound that regulates the activity of a protein suppressing or promoting the aggregation or deposition of amyloid-β protein.
摘要翻译： 本发明提供：抑制或促进淀粉样蛋白-β蛋白的聚集或沉积的蛋白质; 编码蛋白质的多核苷酸; 筛选抑制或促进淀粉样蛋白-β蛋白的聚集或沉积的化合物的方法; 以及用于治疗或预防阿尔茨海默病的治疗剂，其包含调节蛋白质抑制或促进淀粉样蛋白-β蛋白的聚集或沉积的活性的化合物。
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9.发明申请公开(公告)号：US20050164934A1
公开(公告)日：2005-07-28
申请号：US11051410
申请日：2005-02-04
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
IPC分类号： A61K38/00 , C07K14/47 , C12Q1/68 , C07K14/705 , C07K16/28
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译： 使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。 使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。 由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。 证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。 该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。
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公开(公告)号：US06878525B1
公开(公告)日：2005-04-12
申请号：US09979603
申请日：2000-09-13
申请人： Jun Takasaki , Masazumi Kamohara , Mitsuyuki Matsumoto , Tetsu Saito , Tohru Sugimoto , Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Kawai
发明人： Jun Takasaki , Masazumi Kamohara , Mitsuyuki Matsumoto , Tetsu Saito , Tohru Sugimoto , Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Kawai
IPC分类号： A61K38/00 , A61P9/08 , A61P43/00 , C07K14/705 , C12N15/12 , G01N33/68 , G01N33/567
CPC分类号： C07K14/705 , A61K38/00 , G01N33/6893 , G01N2500/00 , G01N2500/04
摘要： A cDNA encoding a novel LTC4 receptor has been isolated. Provision of the novel protein, an LTC4 receptor, enabled binding experiments using the LTC4. By screening for compounds that modulate LTC4 receptor activity based on these binding experiments, development of drugs targeting the LTC4 receptor becomes possible.
摘要翻译： 已经分离出编码新的LTC4受体的cDNA。 提供新的蛋白质LTC4受体，启用使用LTC4的结合实验。 通过筛选基于这些结合实验调节LTC4受体活性的化合物，开发靶向LTC4受体的药物成为可能。
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