公开(公告)号：US20080153872A1

公开(公告)日：2008-06-26

申请号：US11813885

申请日：2006-01-13

申请人： Mladen Mercep ,  Ivica Malnar ,  Boska Hrvacic ,  Stribor Markovic ,  Anita Filipovic Sucic ,  Berislav Bosnjak ,  Andreja Cempuh Klonkay ,  Renata Rupcic ,  Antun Hutinec ,  Ivaylo Jivkov Elenkov ,  Milan Mesic

发明人： Mladen Mercep ,  Ivica Malnar ,  Boska Hrvacic ,  Stribor Markovic ,  Anita Filipovic Sucic ,  Berislav Bosnjak ,  Andreja Cempuh Klonkay ,  Renata Rupcic ,  Antun Hutinec ,  Ivaylo Jivkov Elenkov ,  Milan Mesic

IPC分类号： A61K31/4709 ,  C07D407/06 ,  A61K31/353 ,  A61K31/357 ,  C07D409/14 ,  A61K31/4406 ,  C07D493/14 ,  A61P37/00 ,  A61P29/00 ,  C07D493/04 ,  A61K31/352 ,  C07D401/14 ,  A61K31/381 ,  C07D405/14 ,  A61K31/4155

CPC分类号： C07D413/12 ,  A61K47/545 ,  C07D311/56 ,  C07D407/06 ,  C07D407/14 ,  C07D413/14 ,  C07H17/00 ,  C07H17/08

摘要： Certain bis-(coumarin) compounds as well as the products of their intramolecular cyclization including pharmaceutically acceptable salts, hydrates, solvates, clathrates, prodrugs, tautomers and stereoisomers thereof are disclosed. Certain processes and intermediates for the preparation of certain bis-(coumarin) compounds, as well as for the use of these compounds as therapeutically active agents in the prophylaxis and treatment of asthma and other inflammatory diseases and conditions in mammals, especially humans are also disclosed.

摘要翻译： 公开了某些双 - （香豆素）化合物及其分子内环化的产物，包括其药学上可接受的盐，水合物，溶剂化物，包合物，前药，互变异构体和立体异构体。 还公开了某些制备某些二 - （香豆素）化合物的方法和中间体，以及将这些化合物用作治疗活性剂用于预防和治疗哺乳动物，特别是人类的哮喘和其它炎性疾病和病症 。

公开(公告)号：US07208518B2

公开(公告)日：2007-04-24

申请号：US11338871

申请日：2006-01-23

申请人： Mladen Mercep ,  Milan Mesic ,  Boska Hrvacic ,  Ivaylo Jivkov Elenkov ,  Ivica Malnar ,  Stribor Markovic ,  Lidija Simicic ,  Andreja Cempuh Klonkay ,  Anita Filipovic

发明人： Mladen Mercep ,  Milan Mesic ,  Boska Hrvacic ,  Ivaylo Jivkov Elenkov ,  Ivica Malnar ,  Stribor Markovic ,  Lidija Simicic ,  Andreja Cempuh Klonkay ,  Anita Filipovic

IPC分类号： C07D495/14 ,  C07D495/04 ,  A61K31/352

CPC分类号： C07D493/04

摘要： The present invention relates to novel compounds of the formula (I) including all stereoisomers and tautomers thereof, to the pharmaceutically acceptable salts and solvates thereof, to the processes and reactive intermediates for their preparation and to their use in the prophylaxis and treatment of asthma and other inflammatory diseases and/or conditions in humans.

摘要翻译： 本发明涉及式（I）的新化合物，其包括其所有立体异构体和互变异构体，其药学上可接受的盐和溶剂化物，其制备方法和反应中间体及其在预防和治疗哮喘中的用途和 人类的其他炎性疾病和/或病症。

公开(公告)号：US20060148889A1

公开(公告)日：2006-07-06

申请号：US11337274

申请日：2006-01-20

申请人： Mladen Mercep ,  Milan Mesic ,  Boska Hrvacic ,  Ivaylo Jivkov Elenkov ,  Ivica Malnar ,  Stribor Markovic ,  Lidija Simicic ,  Andreja Cempuh Klonkay ,  Anita Filipovic

发明人： Mladen Mercep ,  Milan Mesic ,  Boska Hrvacic ,  Ivaylo Jivkov Elenkov ,  Ivica Malnar ,  Stribor Markovic ,  Lidija Simicic ,  Andreja Cempuh Klonkay ,  Anita Filipovic

IPC分类号： A61K31/366 ,  C07D493/02

CPC分类号： C07D493/04

摘要： The invention relates to novel compounds of the formula (I) including all their tautomers, to pharmaceutically acceptable salts and solvates thereof, to processes and reactive intermediates for the preparation thereof, and to processes and reactive intermediates for the preparation of the compounds of the formula (II) including all their stereoisomers and tautomers to the use of the compounds of the formula (II) as suitable precursors for the preparation of the compounds of the formula (I) as well as to use of the compounds of the formula (I) and of the compounds of the formula (II) as therapeutically active agents in the prophylaxis and treatment of asthma and other inflammatory diesases and conditions in humans.

摘要翻译： 本发明涉及包含其所有互变异构体，其药学上可接受的盐和溶剂合物的式（I）化合物，其制备方法和反应中间体，以及制备式I化合物的方法和反应中间体 （II）包括其所有立体异构体和互变异构体以使用式（II）化合物作为制备式（I）化合物的合适前体，以及使用式（I）化合物， 和式（II）的化合物作为预防和治疗哮喘和其它炎性糖尿病和人类病症的治疗活性剂。

公开(公告)号：US07384975B2

公开(公告)日：2008-06-10

申请号：US11337274

申请日：2006-01-20

申请人： Mladen Mercep ,  Milan Mesic ,  Boska Hrvacic ,  Ivaylo Jivkov Elenkov ,  Ivica Malnar ,  Stribor Markovic ,  Lidija Simicic ,  Andreja Cempuh Klonkay ,  Anita Filipovic

发明人： Mladen Mercep ,  Milan Mesic ,  Boska Hrvacic ,  Ivaylo Jivkov Elenkov ,  Ivica Malnar ,  Stribor Markovic ,  Lidija Simicic ,  Andreja Cempuh Klonkay ,  Anita Filipovic

IPC分类号： A61K31/353 ,  C07D311/78 ,  C07D407/14

CPC分类号： C07D493/04

摘要： The invention relates to novel compounds of the formula (I) including all their tautomers, to pharmaceutically acceptable salts and solvates thereof, to processes and reactive intermediates for the preparation thereof, and to processes and reactive intermediates for the preparation of the compounds of the formula (II) including all their stereoisomers and tautomers to the use of the compounds of the formula (II) as suitable precursors for the preparation of the compounds of the formula (I) as well as to use of the compounds of the formula (I) and of the compounds of the formula (II) as therapeutically active agents in the prophylaxis and treatment of asthma and other inflammatory diesases and conditions in humans.

摘要翻译： 本发明涉及包含其所有互变异构体，其药学上可接受的盐和溶剂合物的式（I）化合物，其制备方法和反应中间体，以及制备式（I）化合物的方法和反应中间体 （II）包括其所有立体异构体和互变异构体以使用式（II）化合物作为制备式（I）化合物的合适前体，以及使用式（I）化合物， 和式（II）的化合物作为预防和治疗哮喘和其它炎性糖尿病和人类病症的治疗活性剂。