公开(公告)号：US20170258915A1

公开(公告)日：2017-09-14

申请号：US15379284

申请日：2016-12-14

Applicant: ModernaTX, Inc.

Inventor： Antonin de FOUGEROLLES ,  Sayda M. Elbashir

IPC: A61K47/18 ,  A61K31/7088 ,  A61K31/7115 ,  A61K38/19 ,  A61K38/48 ,  A61K47/22 ,  A61K47/28 ,  C07K14/535 ,  C12N15/87 ,  C12N9/64 ,  A61K48/00

CPC classification number: A61K47/18 ,  A61K31/7088 ,  A61K31/7115 ,  A61K38/193 ,  A61K38/4846 ,  A61K47/22 ,  A61K47/28 ,  A61K48/00 ,  C07K14/535 ,  C12N9/644 ,  C12N15/67 ,  C12N15/87 ,  C12N2310/335

Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.

公开(公告)号：US20180000910A1

公开(公告)日：2018-01-04

申请号：US15429532

申请日：2017-02-10

Applicant: ModernaTX, Inc.

Inventor： Tirtha CHAKRABORTY ,  Stephane BANCEL ,  Stephen G. HOGE ,  Atanu ROY ,  Antonin de FOUGEROLLES ,  Noubar B. AFEYAN

IPC: A61K39/00 ,  C12N15/67

CPC classification number: A61K39/00 ,  C12N15/67

Abstract: The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.