公开(公告)号：US20220152178A1

公开(公告)日：2022-05-19

申请号：US17554182

申请日：2021-12-17

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Nicholas Valiante ,  Tal Zaks

IPC: A61K39/00 ,  A61K45/06 ,  A61K47/54 ,  A61K47/68 ,  A61P35/00 ,  A61K9/127 ,  A61K47/26 ,  C12N15/62

Abstract: The invention relates to concatemeric peptide epitope RNAs, as well as methods and compositions thereof. mRNA vaccines are also provided according to the invention, including cancer vaccines.

公开(公告)号：US20250134978A1

公开(公告)日：2025-05-01

申请号：US18807315

申请日：2024-08-16

Applicant: ModernaTX, Inc.

Inventor： Nicholas Valiante ,  Ted Ashburn ,  Kristen Hopson

IPC: A61K39/00 ,  A61K39/39

Abstract: The disclosure relates to cancer ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines. In particular, the disclosure relates to concatemeric mRNA cancer vaccines encoding several cancer epitopes on a single mRNA construct, i.e. poly-epitope mRNA constructs or poly-neo-epitope constructs. The disclosure further relates to p53 and KRAS mutations, as well as incorporation of immune enhancers such as STING, e.g. mRNA constructs further encoding an immune stimulator or adjuvant. The disclosure further relates to inclusion of universal T cell epitopes, such as tetanus or diphtheria toxins to elicit an enhanced immune response.

公开(公告)号：US12150980B2

公开(公告)日：2024-11-26

申请号：US15748773

申请日：2016-07-29

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Nicholas Valiante ,  Tal Zaks

IPC: C12N15/63 ,  A61K9/127 ,  A61K39/00 ,  A61K45/06 ,  A61K47/26 ,  A61K47/54 ,  A61K47/68 ,  A61P35/00 ,  C12N15/62

Abstract: The invention relates to concatemeric peptide epitope RNAs, as well as methods and compositions thereof. mRNA vaccines are also provided according to the invention, including cancer vaccines.

公开(公告)号：US10881730B2

公开(公告)日：2021-01-05

申请号：US16279372

申请日：2019-02-19

Applicant: ModernaTX, Inc.

Inventor： Eric Yi-Chun Huang ,  Sze-Wah Tse ,  Jared Iacovelli ,  Kristine McKinney ,  Nicholas Valiante

IPC: A61K39/39 ,  A61K9/50 ,  C07K14/725 ,  A61K39/00 ,  A61K9/00 ,  A61K9/51 ,  A61P35/00 ,  A61K35/00

Abstract: The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator. The disclosure also features methods of using the same, for example, to stimulate anti-cancer immune responses.

公开(公告)号：US20180318409A1

公开(公告)日：2018-11-08

申请号：US15769710

申请日：2016-10-21

Applicant: ModernaTX, Inc.

Inventor： Nicholas Valiante ,  Tal Zaks ,  Eric Yi-Chun Huang ,  Giuseppe Ciaramella

IPC: A61K39/00 ,  A61K9/51 ,  A61K9/10 ,  A61P35/00

CPC classification number: A61K39/001114 ,  A61K9/10 ,  A61K9/5123 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55588 ,  A61P35/00

Abstract: The disclosure relates to cancer ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US20190351040A1

公开(公告)日：2019-11-21

申请号：US16482844

申请日：2017-10-26

Applicant: ModernaTX, Inc.

Inventor： Nicholas Valiante ,  Ted Ashburn ,  Kristen Flopson

IPC: A61K39/00 ,  A61K39/39

Abstract: The disclosure relates to cancer ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines. In particular, the disclosure relates to concatemeric mRNA cancer vaccines encoding several cancer epitopes on a single mRNA construct, i.e. poly-epitope mRNA constructs or poly-neo-epitope constructs. The disclosure further relates to p53 and KRAS mutations, as well as incorporation of immune enhancers such as STING, e.g. mRNA constructs further encoding an immune stimulator or adjuvant. The disclosure further relates to inclusion of universal T cell epitopes, such as tetanus or diphtheria toxins to elicit an enhanced immune response.

公开(公告)号：US20190008938A1

公开(公告)日：2019-01-10

申请号：US15748773

申请日：2016-07-29

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Nicholas Valiante ,  Tal Zaks

IPC: A61K39/00 ,  A61P35/00 ,  A61K47/68 ,  C12N15/62 ,  A61K9/127 ,  A61K47/54 ,  A61K47/26

Abstract: The invention relates to concatemeric peptide epitope RNAs, as well as methods and compositions thereof. mRNA vaccines are also provided according to the invention, including cancer vaccines.