公开(公告)号：US10881730B2

公开(公告)日：2021-01-05

申请号：US16279372

申请日：2019-02-19

Applicant: ModernaTX, Inc.

Inventor： Eric Yi-Chun Huang ,  Sze-Wah Tse ,  Jared Iacovelli ,  Kristine McKinney ,  Nicholas Valiante

IPC: A61K39/39 ,  A61K9/50 ,  C07K14/725 ,  A61K39/00 ,  A61K9/00 ,  A61K9/51 ,  A61P35/00 ,  A61K35/00

Abstract: The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator. The disclosure also features methods of using the same, for example, to stimulate anti-cancer immune responses.

公开(公告)号：US20240123034A1

公开(公告)日：2024-04-18

申请号：US17768514

申请日：2020-10-15

Applicant: ModernaTX, Inc. ,  BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Eric Yi-Chun Huang ,  Jared Iacovelli ,  Seymour De Picciotto ,  Sze-Wah Tse ,  Laurie Kenney ,  Katherine Olson ,  Howard Gendelman ,  Lee R. Mosley

IPC: A61K38/19 ,  A61K9/51 ,  A61K31/7115 ,  A61P25/16

CPC classification number: A61K38/193 ,  A61K9/5123 ,  A61K31/7115 ,  A61P25/16

Abstract: The disclosure features lipid nanoparticle (LNP) compositions comprising mRNA molecules encoding human granulocyte macrophage colony stimulating factor (GM-CSF) polypeptides and uses thereof in the treatment of Parkinson's Disease. The LNP compositions of the present disclosure comprise mRNA therapeutics encoding human GM-CSF for use in such treatment.