公开(公告)号：US12274743B2

公开(公告)日：2025-04-15

申请号：US18801143

申请日：2024-08-12

Applicant: ModernaTX, INC.

Inventor： Giuseppe Ciaramella ,  Axel Bouchon ,  Eric Yi-Chun Huang

IPC: A61K39/00 ,  A61K9/00 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/51 ,  A61K31/7105 ,  A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K39/39 ,  A61K48/00 ,  A61P31/16 ,  C12N7/00

Abstract: The invention relates to compositions and methods for the preparation, manufacture, and therapeutic use of ribonucleic acid vaccines comprising polynucleotide molecules encoding one or more antigens.

公开(公告)号：US12150980B2

公开(公告)日：2024-11-26

申请号：US15748773

申请日：2016-07-29

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Nicholas Valiante ,  Tal Zaks

IPC: C12N15/63 ,  A61K9/127 ,  A61K39/00 ,  A61K45/06 ,  A61K47/26 ,  A61K47/54 ,  A61K47/68 ,  A61P35/00 ,  C12N15/62

Abstract: The invention relates to concatemeric peptide epitope RNAs, as well as methods and compositions thereof. mRNA vaccines are also provided according to the invention, including cancer vaccines.

公开(公告)号：US20210220467A1

公开(公告)日：2021-07-22

申请号：US17204801

申请日：2021-03-17

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Axel Bouchon ,  Eric Yi-Chun Huang

IPC: A61K39/145 ,  A61K48/00 ,  A61K31/7105 ,  A61K39/12 ,  A61K39/39 ,  A61K9/00 ,  A61K39/155 ,  A61K9/127 ,  A61K9/51 ,  C12N7/00

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.

公开(公告)号：US10881730B2

公开(公告)日：2021-01-05

申请号：US16279372

申请日：2019-02-19

Applicant: ModernaTX, Inc.

Inventor： Eric Yi-Chun Huang ,  Sze-Wah Tse ,  Jared Iacovelli ,  Kristine McKinney ,  Nicholas Valiante

IPC: A61K39/39 ,  A61K9/50 ,  C07K14/725 ,  A61K39/00 ,  A61K9/00 ,  A61K9/51 ,  A61P35/00 ,  A61K35/00

Abstract: The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator. The disclosure also features methods of using the same, for example, to stimulate anti-cancer immune responses.

公开(公告)号：US10517940B2

公开(公告)日：2019-12-31

申请号：US16136386

申请日：2018-09-20

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks

IPC: A61K39/12 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K39/39 ,  A61K48/00 ,  A61K39/42 ,  A61K39/015 ,  A61K39/00

Abstract: The disclosure relates to Zika virus infection and the treatment thereof. The invention includes ribonucleic acid compositions, as well as methods of using the compositions for treating and preventing Zika virus infection.

公开(公告)号：US20190192653A1

公开(公告)日：2019-06-27

申请号：US16053839

申请日：2018-08-03

Applicant: ModernaTX, Inc.

Inventor： Stephen G. Hoge ,  Eric Yi-Chun Huang

IPC: A61K39/39 ,  A61K39/38 ,  C12N15/88 ,  A61K39/00 ,  A61K39/35

CPC classification number: A61K39/39 ,  A61K39/00 ,  A61K39/0008 ,  A61K39/001 ,  A61K39/35 ,  A61K39/38 ,  A61K2039/53 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/572 ,  C12N15/88

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of molecules for tolerizing cellular systems.

公开(公告)号：US20190015501A1

公开(公告)日：2019-01-17

申请号：US16144394

申请日：2018-09-27

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Axel Bouchon ,  Eric Yi-Chun Huang

IPC: A61K39/145 ,  A61K48/00 ,  A61K9/127 ,  A61K9/51 ,  A61K31/7105 ,  A61K39/12 ,  C12N7/00 ,  A61K9/00 ,  A61K39/39 ,  A61K39/155 ,  A61K39/00

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.

公开(公告)号：US20190000959A1

公开(公告)日：2019-01-03

申请号：US16048154

申请日：2018-07-27

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Axel Bouchon ,  Eric Yi-Chun Huang

IPC: A61K39/145 ,  A61K9/00 ,  A61K48/00 ,  C12N7/00 ,  A61K9/127 ,  A61K9/51

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.

公开(公告)号：US20180318409A1

公开(公告)日：2018-11-08

申请号：US15769710

申请日：2016-10-21

Applicant: ModernaTX, Inc.

Inventor： Nicholas Valiante ,  Tal Zaks ,  Eric Yi-Chun Huang ,  Giuseppe Ciaramella

IPC: A61K39/00 ,  A61K9/51 ,  A61K9/10 ,  A61P35/00

CPC classification number: A61K39/001114 ,  A61K9/10 ,  A61K9/5123 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55588 ,  A61P35/00

Abstract: The disclosure relates to cancer ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US20240366745A1

公开(公告)日：2024-11-07

申请号：US18635203

申请日：2024-04-15

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks

IPC: A61K39/12 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K39/00 ,  A61K39/015 ,  A61K39/39 ,  A61K39/42 ,  A61K48/00 ,  A61P11/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.