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公开(公告)号：US12246029B2
公开(公告)日：2025-03-11
申请号：US17523034
申请日：2021-11-10
Applicant: ModernaTX, Inc.
Inventor： Stephen Hoge , William Issa , Edward J. Miracco , Jennifer Nelson , Amy E. Rabideau , Gabor Butora
IPC: A61K31/7105 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , C07K14/505 , C12N15/10 , C12P19/34 , G01N33/68
Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
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公开(公告)号：US20180363019A1
公开(公告)日：2018-12-20
申请号：US16001786
申请日：2018-06-06
Applicant: ModernaTX, Inc.
Inventor： Stephen Hoge , William Issa , Edward J. Miracco , Jennifer Nelson , Amy E. Rabideau , Gabor Butora
IPC: C12P19/34
Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by inproved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
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公开(公告)号：US10072057B2
公开(公告)日：2018-09-11
申请号：US15656740
申请日：2017-07-21
Applicant: ModernaTX, Inc.
Inventor： Stephen G. Hoge , William Joseph Issa , Edward John Miracco , Jennifer Nelson , John Reynders , Matthew Stanton
IPC: C07K14/535 , C12P19/34 , C07K14/505 , C12N9/00 , A61K48/00 , C12P21/02 , C12N9/02
CPC classification number: C07K14/535 , A61K48/005 , C07K14/505 , C12N9/0069 , C12P19/34 , C12P21/02 , C12Y113/12007
Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.
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公开(公告)号：US12233084B2
公开(公告)日：2025-02-25
申请号：US17523060
申请日：2021-11-10
Applicant: ModernaTX, Inc.
Inventor： Stephen Hoge , William Issa , Edward J. Miracco , Jennifer Nelson , Amy E. Rabideau , Gabor Butora
IPC: A61K31/7105 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , C07K14/505 , C12N15/10 , C12P19/34 , G01N33/68
Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by inproved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
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公开(公告)号：US12071620B2
公开(公告)日：2024-08-27
申请号：US17929956
申请日：2022-09-06
Applicant: ModernaTX, Inc.
Inventor： Gabor Butora , Andrew W. Fraley , Edward John Miracco , Jennifer Nelson , Amy Rhoden Smith , Matthew Stanton
IPC: C12N15/113 , C12N15/11
CPC classification number: C12N15/113 , C12N15/111 , C12N2310/317 , C12N2310/321 , C12N2310/3231 , C12N2310/3233 , C12N2310/351 , C12N2320/51
Abstract: The disclosure provides polynucleotides encoding a polypeptide including a morpholino linker. In some embodiments, the polynucleotides of the invention have increased stability compared to wild-type polynucleotides.
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Patent Agency Ranking
公开(公告)号：US20190247417A1
公开(公告)日：2019-08-15
申请号：US16333330
申请日：2017-09-14
Applicant: ModernaTX, Inc.
Inventor： Stephen Hoge , William Issa , Edward J. Miracco , Jennifer Nelson , Amy E. Rabideau , Gabor Butora
CPC classification number: A61K31/7105 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , C07K14/505 , C12N15/10 , C12P19/34 , G01N33/6851
Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
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公开(公告)号：US20180009866A1
公开(公告)日：2018-01-11
申请号：US15656740
申请日：2017-07-21
Applicant: ModernaTX, Inc.
Inventor： Stephen G. Hoge , William Joseph Issa , Edward John Miracco , Jennifer Nelson , John Reynders , Matthew Stanton
IPC: C07K14/535 , C07K14/505 , C12N9/02 , C12P19/34
CPC classification number: C07K14/535 , A61K48/005 , C07K14/505 , C12N9/0069 , C12P19/34 , C12P21/02 , C12Y113/12007
Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.
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公开(公告)号：US20220096522A1
公开(公告)日：2022-03-31
申请号：US17523060
申请日：2021-11-10
Applicant: ModernaTX, Inc.
Inventor： Stephen Hoge , William Issa , Edward J. Miracco , Jennifer Nelson , Amy E. Rabideau , Gabor Butora
IPC: A61K31/7105 , C07K14/505 , C12P19/34 , A61P33/00 , A61P31/12 , A61P31/04 , A61P35/00 , C12N15/10 , G01N33/68
Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by inproved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
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公开(公告)号：US20220096521A1
公开(公告)日：2022-03-31
申请号：US17523034
申请日：2021-11-10
Applicant: ModernaTX, Inc.
Inventor： Stephen Hoge , William Issa , Edward J. Miracco , Jennifer Nelson , Amy E. Rabideau , Gabor Butora
IPC: A61K31/7105 , C07K14/505 , C12P19/34 , A61P33/00 , A61P31/12 , A61P31/04 , A61P35/00 , C12N15/10 , G01N33/68
Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
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公开(公告)号：US10407683B2
公开(公告)日：2019-09-10
申请号：US15326059
申请日：2015-07-16
Applicant: ModernaTX, Inc.
Inventor： Jennifer Nelson , Andrew W. Fraley , Amy Rhoden Smith
IPC: C12N15/64 , C07H21/02 , A61K48/00 , C07K14/535 , C12N15/10
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of circular polynucleotides.
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