公开(公告)号：US10407683B2

公开(公告)日：2019-09-10

申请号：US15326059

申请日：2015-07-16

Applicant: ModernaTX, Inc.

Inventor： Jennifer Nelson ,  Andrew W. Fraley ,  Amy Rhoden Smith

IPC: C12N15/64 ,  C07H21/02 ,  A61K48/00 ,  C07K14/535 ,  C12N15/10

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of circular polynucleotides.

公开(公告)号：US12109274B2

公开(公告)日：2024-10-08

申请号：US15760686

申请日：2016-09-19

Applicant: ModernaTX, Inc.

Inventor： Gabor Butora ,  Andrew W. Fraley ,  Edward John Miracco ,  Jennifer Nelson ,  Amy Rhoden Smith ,  Matthew Stanton ,  Brian R. Fritz

IPC: A61K48/00 ,  C07F9/6558 ,  C07F9/6561 ,  C07H21/02 ,  C12N15/67

CPC classification number: A61K48/0066 ,  C07F9/65586 ,  C07F9/65616 ,  C07H21/02 ,  C12N15/67

Abstract: The invention features polynucleotides encoding a polypeptide including a 3′-stabilizing region and having increased stability compared to wild-type polynucleotides.

公开(公告)号：US12071620B2

公开(公告)日：2024-08-27

申请号：US17929956

申请日：2022-09-06

Applicant: ModernaTX, Inc.

Inventor： Gabor Butora ,  Andrew W. Fraley ,  Edward John Miracco ,  Jennifer Nelson ,  Amy Rhoden Smith ,  Matthew Stanton

IPC: C12N15/113 ,  C12N15/11

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3233 ,  C12N2310/351 ,  C12N2320/51

Abstract: The disclosure provides polynucleotides encoding a polypeptide including a morpholino linker. In some embodiments, the polynucleotides of the invention have increased stability compared to wild-type polynucleotides.

公开(公告)号：US20230323344A1

公开(公告)日：2023-10-12

申请号：US17929956

申请日：2022-09-06

Applicant: ModernaTx, Inc.

Inventor： Gabor BUTORA ,  Andrew W. Fraley ,  Edward John Miracco ,  Jennifer Nelson ,  Amy Rhoden Smith ,  Matthew Stanton

IPC: C12N15/113 ,  C12N15/11

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3233 ,  C12N2310/351 ,  C12N2320/51

Abstract: The disclosure provides polynucleotides encoding a polypeptide including a morpholino linker. In some embodiments, the polynucleotides of the invention have increased stability compared to wild-type polynucleotides.

公开(公告)号：US11434486B2

公开(公告)日：2022-09-06

申请号：US15760667

申请日：2016-09-19

Applicant: ModernaTX, Inc.

Inventor： Gabor Butora ,  Andrew W. Fraley ,  Edward John Miracco ,  Jennifer Nelson ,  Amy Rhoden Smith ,  Matthew Stanton

IPC: A01N43/04 ,  A61K31/70 ,  C12N15/113 ,  C12N15/11

Abstract: The disclosure provides polynucleotides encoding a polypeptide including a morpholino linker. In some embodiments, the polynucleotides of the invention have increased stability compared to wild-type polynucleotides.

公开(公告)号：US10385088B2

公开(公告)日：2019-08-20

申请号：US15026836

申请日：2014-10-02

Applicant: ModernaTX, Inc.

Inventor： Andrew W. Fraley ,  Atanu Roy ,  Matthew Stanton

IPC: C07H19/10 ,  C07H19/067 ,  C07H19/167 ,  C07H21/02 ,  C07H19/20 ,  C07K14/525 ,  C07K14/535 ,  C07K14/565

Abstract: The present disclosure provides alternative sugar moieties and polynucleotides comprising such sugar moieties, and methods of use thereof.

公开(公告)号：US10286086B2

公开(公告)日：2019-05-14

申请号：US15319840

申请日：2015-06-19

Applicant: ModernaTX, Inc.

Inventor： Atanu Roy ,  Christopher R. Conlee ,  Antonin De Fougerolles ,  Andrew W. Fraley ,  Gabor Butora ,  Matthew Stanton

IPC: A61K48/00 ,  C07F9/6558 ,  C07H19/06 ,  C07H19/16 ,  C12N15/11 ,  C12N15/67 ,  C07H21/02 ,  C07F9/6561 ,  C07D405/04 ,  C07D239/54 ,  C07H19/067 ,  C07H19/10 ,  C07H19/14 ,  C07H19/167 ,  C07H19/20 ,  C07H19/23 ,  C07D473/16 ,  C07D473/18 ,  C07D473/30 ,  C07D473/34 ,  C07D473/38 ,  C07D473/40 ,  C07D487/04 ,  C07D487/16 ,  C07D498/22 ,  C12N15/87

Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.