公开(公告)号：US20190079068A1

公开(公告)日：2019-03-14

申请号：US16046675

申请日：2018-07-26

申请人： Mohammad E. Taslim ,  Mohammed Fotouhi ,  Mehdi Abedi ,  Reza Mollaaghababa ,  Bahram Fotouhi ,  Kashayar Javaherian ,  Edward Alvin Greenfield ,  Namal Nawana

发明人： Mohammad E. Taslim ,  Mohammed Fotouhi ,  Mehdi Abedi ,  Reza Mollaaghababa ,  Bahram Fotouhi ,  Kashayar Javaherian ,  Edward Alvin Greenfield ,  Namal Nawana

IPC分类号： G01N33/487 ,  C01B32/174 ,  C12Q1/06 ,  C12Q1/14 ,  B01L3/00

摘要： Methods and devices for detecting a target agent of interest, e.g., a pathogen, in a sample are described herein. In some embodiments, a sensor is provided that can include a substrate, a graphene layer disposed on a surface of said substrate, and a protein bound to said graphene layer. The protein can be capable of binding to one or more target agents of interest, e.g., pathogens, etc. The binding of the protein to the one or more target agents of interest can generate a change in an electrical property of the graphene layer.

公开(公告)号：US20190284615A1

公开(公告)日：2019-09-19

申请号：US16260773

申请日：2019-01-29

申请人： Namal Nawana ,  Rite Taste, LLC

发明人： Mohammed Fotouhi ,  Mohammad E. Taslim ,  Mehdi Abedi ,  Edward Alvin Greenfield ,  Reza Mollaaghababa ,  Namal Nawana

IPC分类号： C12Q1/689 ,  G01N33/569 ,  C12Q1/04

摘要： In one aspect, a method of detecting a pathogen, e.g., listeria bacterium, chlamydia bacteria, gonorrhea bacteria and/or HPV, in a sample is disclosed, which comprises bringing a sample into contact with a graphene layer functionalized with an antibody exhibiting specific binding to the pathogen, monitoring electrical resistance of said antibody-functionalized graphene layer in response to interaction with said sample, and detecting presence of the pathogen in said sample by detecting a change in said electrical resistance indicative of interaction of the pathogen with said antibody-functionalized graphene layer. For example, a decrease of the electrical resistance of the graphene layer can indicate the presence of the pathogen in the sample under study. In some embodiments, a method according to the present teachings is capable of detecting pathogens, such as listeria bacteria, chlamydia bacteria, gonorrhea bacteria and HPV in a sample at a concentration as low as 4 cfu per 100 grams of a sample.

公开(公告)号：US20190317081A1

公开(公告)日：2019-10-17

申请号：US16422770

申请日：2019-05-24

申请人： Namal Nawana ,  Rite Taste, LLC

发明人： Mohammad E. Taslim ,  Mohammed Fotouhi ,  Mehdi Abedi ,  Reza Mollaaghababa ,  Bahram Fotouhi ,  Kashayar Javaherian ,  Edward Alvin Greenfield ,  Namal Nawana

IPC分类号： G01N33/53 ,  G01N33/544 ,  G01N33/02 ,  G01N27/04 ,  G01N33/552 ,  B01L3/00 ,  G01N33/543 ,  G01N1/40 ,  G01N33/551 ,  G01N1/28 ,  G01N33/68

摘要： A processing and detection system for detecting presence of at least one gluten protein in a food sample comprises a food processor including: a reservoir containing a process liquid for processing the food sample; a body that comprises a chamber configured to receive the food sample; and a pressing surface configured to press on the reservoir to cause the process liquid to exit the reservoir and mix with the food sample, thereby generating a processed food liquid; and an exit port configured to conduct the processed food liquid out of the food processor; and a cartridge including: at least one sensor configured to receive the processed food liquid and to generate an electrical signal in response to interaction with the at least one gluten protein in the processed food liquid, and an analyzer in electrical communication with the at least one sensor for detecting the electrical signal and determining the presence of the at least one gluten protein in the food sample based on the detected electrical signal.

公开(公告)号：US10782285B2

公开(公告)日：2020-09-22

申请号：US16422770

申请日：2019-05-24

申请人： Rite Taste, LLC ,  Namal Nawana

发明人： Mohammad E. Taslim ,  Mohammed Fotouhi ,  Mehdi Abedi ,  Reza Mollaaghababa ,  Bahram Fotouhi ,  Kashayar Javaherian ,  Edward Alvin Greenfield ,  Namal Nawana

IPC分类号： G01N33/53 ,  G01N33/544 ,  G01N33/02 ,  G01N27/04 ,  G01N33/552 ,  B01L3/00 ,  G01N33/543 ,  G01N33/551 ,  G01N33/68 ,  G01N1/40 ,  G01N1/28

摘要： A processing and detection system for detecting presence of at least one gluten protein in a food sample comprises a food processor including: a reservoir containing a process liquid for processing the food sample; a body that comprises a chamber configured to receive the food sample; and a pressing surface configured to press on the reservoir to cause the process liquid to exit the reservoir and mix with the food sample, thereby generating a processed food liquid; and an exit port configured to conduct the processed food liquid out of the food processor; and a cartridge including: at least one sensor configured to receive the processed food liquid and to generate an electrical signal in response to interaction with the at least one gluten protein in the processed food liquid, and an analyzer in electrical communication with the at least one sensor for detecting the electrical signal and determining the presence of the at least one gluten protein in the food sample based on the detected electrical signal.

公开(公告)号：US20200011860A1

公开(公告)日：2020-01-09

申请号：US16422743

申请日：2019-05-24

申请人： Namal Nawana ,  Rite Taste, LLC

发明人： Namal Nawana ,  Mohammad E. Taslim ,  Mohammed Fotouhi ,  Mehdi Abedi ,  Reza Mollaaghababa ,  Edward Alvin Greenfield

IPC分类号： G01N33/543 ,  B01L3/00 ,  G01N27/12

摘要： In one aspect, the present teachings provide a sensor for detecting troponin, e.g., cardiac troponin in a patient's blood, that relies on an electronic signature generated via interaction of troponin with an anti-troponin antibody. More specifically, as discussed in more detail below, such a sensor can include a graphene layer disposed on an underlying substrate, where the graphene layer has been functionalized with an anti-troponin antibody. The interaction of troponin in a sample, e.g., a patient's blood, with the anti-troponin antibody coupled, e.g., anchored, to the graphene substrate, can modulate an electronic property of the underlying graphene layer. The modulation of the electronic property of the graphene layer can be measured and used to identify, and in some embodiments quantify, troponin in the sample.