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1.发明授权Apparatus for studying the effects of compressive and tensile bending strains on bones 失效用于研究压缩和拉伸弯曲应变对骨骼的影响的装置
公开(公告)号：US5383474A
公开(公告)日：1995-01-24
申请号：US134446
申请日：1993-10-12
CPC分类号： A61B5/4504 , G01N3/08 , G01N3/20
摘要： An apparatus for applying compressive and tensile loads on bones having a frame with a work surface and a stepper motor. The stepper motor is operably connected to a rotational force to linear force converter which is in turn connected to an articulating arm for applying force to a first pair of pads. A second pair of pads is mounted to the work surface such that a bone may be placed across the second pair of pads such that either end of the bone is supported by the second pair of pads and such that the activation of the stepper motor causes the upper pair of pads to exert compressive bending strain on the lateral surface of the bone and such that the lower pair of pads exert tensile bending strain on the medial surface of the bone. A method of modifying hard tissue morphology is also described.
摘要翻译： 一种用于在具有工作表面的框架和步进电机的骨头上施加压缩和拉伸载荷的装置。 步进电动机可操作地连接到线性力转换器的旋转力，线性力转换器又连接到用于向第一对衬垫施加力的铰接臂。 第二对垫被安装到工作表面，使得骨骼可以跨越第二对衬垫放置，使得骨的任一端由第二对衬垫支撑，并且使得步进电动机的启动使得 上一对垫，以在骨的侧表面上施加压缩弯曲应变，并且使得下一对垫在骨的内侧表面上施加拉伸弯曲应变。 还描述了改变硬组织形态的方法。
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2.发明授权Treatment for osteoporosis using growth hormone releasing factor (GRF) in combination with parathyroid hormone (PTH) 失效使用生长激素释放因子（GRF）与PARATHYROID HORMONE（PTH）联合治疗骨质疏松症
公开(公告)号：US5164368A
公开(公告)日：1992-11-17
申请号：US787051
申请日：1991-11-04
申请人： Robert R. Recker
发明人： Robert R. Recker
CPC分类号： A61K38/29
摘要： A method of treating osteoporosis, especially postmenopausal osteoporosis, by administering on a periodic but regular basis to a patient growth hormone releasing factor, GRF(1-44)-NH.sub.2, or a biologically active analog thereof, and concurrently administering parathyroid hormone, PTH(1-34)-NH.sub.2 and continuing the administration until bone mass increases and the patient's calcium balance becomes positive and indicates a mineral accumulation in the skeleton.
摘要翻译： 一种治疗骨质疏松症，特别是绝经后骨质疏松症的方法，通过定期给予患者生长激素释放因子GRF（1-44）-NH2或其生物活性类似物，同时施用甲状旁腺激素PTH（ 1-34）-NH 2，并继续施用，直到骨量增加，并且患者的钙平衡变为阳性并且指示骨骼中的矿物质积累。
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公开(公告)号：US4710382A
公开(公告)日：1987-12-01
申请号：US780949
申请日：1985-09-27
申请人： Robert R. Recker
发明人： Robert R. Recker
摘要： A method of treating osteoporosis, especially postmenopausal osteoporosis, by administering on a periodic but regular basis to a patient growth hormone releasing factor, GRF(1-44)--NH.sub.2, or a biologically active analog thereof, and continuing the administration until bone mass increases and the patient's calcium balance becomes positive and indicates a mineral accumulation in the skeleton.
摘要翻译： 一种治疗骨质疏松症，特别是绝经后骨质疏松症的方法，通过定期给予患者生长激素释放因子GRF（1-44）-NH2或其生物活性类似物，并继续给药直至骨质量增加 并且患者的钙平衡变为阳性，并表示骨骼中的矿物质积累。
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公开(公告)号：US06770461B1
公开(公告)日：2004-08-03
申请号：US09544398
申请日：2000-04-05
IPC分类号： C12P2100
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/705 , C07K14/775
摘要： The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
摘要翻译： 本发明涉及用于分离和检测高骨量基因和相应野生型基因的方法和材料及其突变体。 本发明还涉及高骨量基因，相应的野生型基因及其突变体。本发明鉴定的基因涉及骨发育。 本发明还提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法 在骨发育。 在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。
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5.发明授权Method and treatment composition for decreasing patient time in catabolic state after traumatic injury 失效创伤性损伤后分解代谢状态患者时间减少的方法和治疗组合物
公开(公告)号：US5700775A
公开(公告)日：1997-12-23
申请号：US410353
申请日：1995-03-24
CPC分类号： A61K38/25
摘要： A method of decreasing patient time in a catabolic state after a traumatic injury. The patient is administered systemically human growth hormone releasing factor or a biologically active analog of human growth hormone releasing factor. Administration in the case of voluntary traumatic injury such as surgery occurs just prior to commencing the surgery and thereafter continuing until recovery. In this way the time in a catabolic state is significantly decreased, and the patient moves more quickly to desired anabolic state necessary for recovery.
摘要翻译： 创伤性损伤后分解代谢状态下患者时间缩短的方法。 患者被系统地施用人生长激素释放因子或人生长激素释放因子的生物活性类似物。 在自愿创伤性损伤（例如外科手术）的情况下，在开始手术之前进行管理，此后继续进行恢复。 以这种方式，分解代谢状态的时间显着降低，并且患者更快地移动到恢复所需的期望的合成代谢状态。
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公开(公告)号：US06780609B1
公开(公告)日：2004-08-24
申请号：US09543771
申请日：2000-04-05
IPC分类号： C12P2106
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/705 , C07K14/775
摘要： The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
摘要翻译： 本发明涉及用于分离和检测高骨量基因和相应野生型基因的方法和材料及其突变体。 本发明还涉及高骨量基因，相应的野生型基因及其突变体。 在本发明中鉴定的基因涉及骨发育。 本发明还提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法 在骨发育。 在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。
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公开(公告)号：US5691153A
公开(公告)日：1997-11-25
申请号：US708175
申请日：1996-09-06
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides the chromosome location of an autosomal dominant gene associated with high bone mass. As a result of this localization, the presence of a polymorphism linked to the autosomal dominant gene in a subject can be detected by analyzing human chromosome 11 of the subject for the presence of the polymorphism located about 30 cM around D11S987 and linked to the autosomal dominant gene. The analysis of chromosome 11 can be accomplished by amplifying the polymorphism, separating the amplified polymorphism to generate a polymorphism pattern, and correlating the presence or absence of the polymorphism with the respective presence or absence of the autosomal dominant gene associated with high bone mass.
摘要翻译： 本发明提供了与高骨量相关的常染色体显性遗传基因的染色体位置。 作为该定位的结果，可以通过分析受试者的人类染色体11存在位于D11S987周围约30cM的多态性并与常染色体显性相关的多态性来检测与受试者中常染色体显性遗传基因连锁的多态性 基因。 可以通过扩增多态性，分离扩增多态性以产生多态性模式，并将多态性的存在与否与相应高骨组织相关的常染色体显性遗传基因的存在或不存在相关联来实现第11号染色体的分析。
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公开(公告)号：US07285400B2
公开(公告)日：2007-10-23
申请号：US10731739
申请日：2003-12-10
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/705 , C07K14/775
摘要： The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
摘要翻译： 本发明涉及用于分离和检测高骨量基因和相应野生型基因的方法和材料及其突变体。 本发明还涉及高骨量基因，相应的野生型基因及其突变体。 在本发明中鉴定的基因涉及骨发育。 本发明还提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法 在骨发育。 在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。
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9.发明授权Treatment for osteoporosis using GRF or a biologically active analog thereof 失效使用GRF或其生物活性类似物治疗骨质疏松症
公开(公告)号：US4870054A
公开(公告)日：1989-09-26
申请号：US80110
申请日：1987-07-31
申请人： Robert R. Recker
发明人： Robert R. Recker
摘要： A method of treating osteoporosis, especially post-menopausal osteoporosis, by administering on a periodic but regular basis to a patient growth hormone releasing factor, GRF(1-44)-NH.sub.2, or a biologically active analog thereof, and continuing the administration until bone mass increases and the patient's calcium balance becomes positive and indicates a mineral accumulation in the skeleton.
摘要翻译： 一种治疗骨质疏松症，特别是绝经后骨质疏松症的方法，通过定期给予患者生长激素释放因子GRF（1-44）-NH2或其生物活性类似物，并继续给药至骨骼 质量增加，患者的钙平衡变为阳性，表明骨骼中矿物质积聚。
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