公开(公告)号：US06780609B1

公开(公告)日：2004-08-24

申请号：US09543771

申请日：2000-04-05

申请人： John P. Carulli ,  Randall D. Little ,  Robert R. Recker ,  Mark L. Johnson

发明人： John P. Carulli ,  Randall D. Little ,  Robert R. Recker ,  Mark L. Johnson

IPC分类号： C12P2106

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/775

摘要： The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.

摘要翻译： 本发明涉及用于分离和检测高骨量基因和相应野生型基因的方法和材料及其突变体。 本发明还涉及高骨量基因，相应的野生型基因及其突变体。 在本发明中鉴定的基因涉及骨发育。 本发明还提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法 在骨发育。 在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。

公开(公告)号：US07285400B2

公开(公告)日：2007-10-23

申请号：US10731739

申请日：2003-12-10

申请人： John P. Carulli ,  Randall D. Little ,  Robert R. Recker ,  Mark L. Johnson

发明人： John P. Carulli ,  Randall D. Little ,  Robert R. Recker ,  Mark L. Johnson

IPC分类号： C12P21/00 ,  C12N15/63 ,  C12N15/11

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/775

摘要： The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.

摘要翻译： 本发明涉及用于分离和检测高骨量基因和相应野生型基因的方法和材料及其突变体。 本发明还涉及高骨量基因，相应的野生型基因及其突变体。 在本发明中鉴定的基因涉及骨发育。 本发明还提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法 在骨发育。 在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。

公开(公告)号：US06770461B1

公开(公告)日：2004-08-03

申请号：US09544398

申请日：2000-04-05

申请人： John P. Carulli ,  Randall D. Little ,  Robert R. Recker ,  Mark L. Johnson

发明人： John P. Carulli ,  Randall D. Little ,  Robert R. Recker ,  Mark L. Johnson

IPC分类号： C12P2100

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/775

摘要： The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.

摘要翻译： 本发明涉及用于分离和检测高骨量基因和相应野生型基因的方法和材料及其突变体。 本发明还涉及高骨量基因，相应的野生型基因及其突变体。本发明鉴定的基因涉及骨发育。 本发明还提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法 在骨发育。 在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。

公开(公告)号：US07151161B1

公开(公告)日：2006-12-19

申请号：US10185047

申请日：2002-07-01

申请人： John P. Carulli ,  Randall D. Little ,  Richard Del Mastro ,  Mark Osborne

发明人： John P. Carulli ,  Randall D. Little ,  Richard Del Mastro ,  Mark Osborne

IPC分类号： C07K14/00 ,  C12P21/06 ,  C12N5/00 ,  C12N15/00 ,  C12N15/63

CPC分类号： C07K14/47

摘要： This invention relates to isolated nucleic acids comprising novel genes of a 20 cM region of human chromosome 11q13.3 and the proteins encoded by these genes. Expression vectors and host cells containing these genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.

摘要翻译： 本发明涉及分离的核酸，其包含人染色体11q13.3的20cM区域的新基因和由这些基因编码的蛋白质。 包含这些基因或其片段的表达载体和宿主细胞以及由这些核酸编码的蛋白质的抗体也包括在本文中。

公开(公告)号：US20100303813A1

公开(公告)日：2010-12-02

申请号：US12663335

申请日：2008-06-06

申请人： John P. Carulli ,  Peter K. Gregersen ,  Franak Batliwalla ,  Jadwiga Bienkowska ,  Chunyu Liu

发明人： John P. Carulli ,  Peter K. Gregersen ,  Franak Batliwalla ,  Jadwiga Bienkowska ,  Chunyu Liu

IPC分类号： A61K39/395 ,  C12Q1/68 ,  G01N33/564 ,  G01N33/68 ,  C40B40/08 ,  A61K31/60 ,  A61K38/13 ,  A61K31/7105 ,  A61P29/00

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present disclosure provides biomarkers that are predictive a subject's responsiveness or non-responsiveness to an anti-TNF therapy. The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities (e.g., an anti-TNF therapy or a non-anti-TNF therapy) for a subject suffering from a disease such as an immune disorder.

摘要翻译： 本公开提供了预测受试者对抗TNF治疗的反应性或非反应性的生物标志物。 本文描述的生物标志物，组合物和方法可用于选择患有诸如免疫疾病的疾病的受试者的合适的治疗方式（例如抗TNF治疗或非抗TNF治疗）。