公开(公告)号：US20220125933A1

公开(公告)日：2022-04-28

申请号：US17310871

申请日：2020-02-28

Applicant: PureTech LYT, Inc. ,  Monash University

Inventor： Joseph BOLEN ,  Daniel Kenneth BONNER ,  Ketki KARANAM ,  Christopher John PORTER ,  Jamie SIMPSON ,  Natalie TREVASKIS ,  Dan ZHENG ,  Nathania LEONG ,  Garima SHARMA ,  Mitchell MCINERNEY ,  Tim QUACH ,  Sifei HAN

IPC: A61K47/54 ,  A61K31/519 ,  A61K31/529 ,  A61K31/437 ,  A61K31/4985 ,  A61P35/00

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

公开(公告)号：US20250152550A1

公开(公告)日：2025-05-15

申请号：US18250509

申请日：2021-10-26

Applicant: Monash University ,  Auckland University

Inventor： Natalie TREVASKIS ,  Christopher John PORTER ,  Given LEE ,  Sifel HAN ,  Anthony PHILLIPS ,  John WINDSOR ,  Jiwon HONG ,  Ian Kenneth STYLES ,  Zijun LU

IPC: A61K31/337 ,  A61K9/00 ,  A61K9/107 ,  A61K47/12 ,  A61P1/18

Abstract: The present invention relates to pharmaceutical formulations comprising a lipase inhibitor and long-chain fatty acids. The formulation enables the lipase inhibitor to be delivered to the intestinal lymph and are thereby useful in the treatment or prevention of diseases and conditions mediated by pancreatic lipase, such as acute pancreatitis and associated syndromes.

公开(公告)号：US20210300962A1

公开(公告)日：2021-09-30

申请号：US17264247

申请日：2019-08-02

Applicant: PureTech LYT, Inc. ,  Monash University

Inventor： Daniel Kenneth BONNER ,  Ketki KARANAM ,  Jamie SIMPSON ,  Christopher John PORTER ,  Natalie TREVASKIS ,  Tim QUACH ,  Sifei HAN ,  Luojuan HU

IPC: C07J7/00 ,  A61K45/06 ,  A61K9/00

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

公开(公告)号：US20230062834A1

公开(公告)日：2023-03-02

申请号：US16955084

申请日：2018-12-19

Applicant: PureTech LYT, Inc. ,  Monash University

Inventor： Daniel Kenneth BONNER ,  Sifei HAN ,  Luojuan HU ,  Ketki KARANAM ,  Christopher John PORTER ,  Tim QUACH ,  Rishab R. SHYAM ,  Jamie SIMPSON ,  Natalie TREVASKIS

IPC: C07D498/18 ,  A61P37/06

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

公开(公告)号：US20220339168A1

公开(公告)日：2022-10-27

申请号：US17753936

申请日：2020-09-21

Applicant: Monash University

Inventor： Natalie TREVASKIS ,  Christopher John PORTER ,  Tim QUACH ,  Sifei HAN ,  Enyuan CAO ,  Luojuan HU ,  Matthew WATT

IPC: A61K31/635 ,  A61K31/404 ,  A61P3/04

Abstract: The present invention provides methods of treating metabolic diseases including obesity, insulin resistance and type 2 diabetes with inhibitors of COX-2 or VEGFR and lipid prodrugs of COX-2 inhibitors, in particular celecoxib lipid prodrugs, that promote transport of the pharmaceutical agent to the lymphatic system and which enhance release of the parent agent.

公开(公告)号：US20210268115A1

公开(公告)日：2021-09-02

申请号：US17169371

申请日：2021-02-05

Applicant: PureTech LYT, Inc. ,  Monash University

Inventor： Daniel Kenneth BONNER ,  Rishab R. SHYAM ,  Jamie SIMPSON ,  Christopher John PORTER ,  Natalie TREVASKIS ,  Tim QUACH ,  Sifei HAN ,  Luojuan HU

IPC: A61K47/55 ,  A61K9/00 ,  A61K31/573

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.