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公开(公告)号：US20210300962A1
公开(公告)日：2021-09-30
申请号：US17264247
申请日：2019-08-02
发明人： Daniel Kenneth BONNER , Ketki KARANAM , Jamie SIMPSON , Christopher John PORTER , Natalie TREVASKIS , Tim QUACH , Sifei HAN , Luojuan HU
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
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公开(公告)号：US20220125933A1
公开(公告)日：2022-04-28
申请号：US17310871
申请日：2020-02-28
发明人： Joseph BOLEN , Daniel Kenneth BONNER , Ketki KARANAM , Christopher John PORTER , Jamie SIMPSON , Natalie TREVASKIS , Dan ZHENG , Nathania LEONG , Garima SHARMA , Mitchell MCINERNEY , Tim QUACH , Sifei HAN
IPC分类号： A61K47/54 , A61K31/519 , A61K31/529 , A61K31/437 , A61K31/4985 , A61P35/00
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
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公开(公告)号：US20180243425A1
公开(公告)日：2018-08-30
申请号：US15758633
申请日：2016-09-08
申请人： Monash University
发明人： Chris FORTER , Jamie SIMPSON , Natalie TREVASKIS , Tim QUACH , Sifei HAN , Luojuan HU
IPC分类号： A61K47/54 , A61K31/568 , A61K31/27 , A61K31/485 , A61K31/167 , A61K31/138 , A61K31/365 , A61K9/00 , A61K45/06
CPC分类号： A61K47/542 , A61K9/0053 , A61K31/138 , A61K31/165 , A61K31/167 , A61K31/222 , A61K31/27 , A61K31/365 , A61K31/485 , A61K31/568 , A61K45/06 , C07C219/06 , C07C235/36 , C07C271/24 , C07C2602/26 , C07D307/88 , C07D489/12 , C07J1/0025 , C07J1/0029 , A61K2300/00
摘要： The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that pro mote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.
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公开(公告)号：US20230062834A1
公开(公告)日：2023-03-02
申请号：US16955084
申请日：2018-12-19
发明人： Daniel Kenneth BONNER , Sifei HAN , Luojuan HU , Ketki KARANAM , Christopher John PORTER , Tim QUACH , Rishab R. SHYAM , Jamie SIMPSON , Natalie TREVASKIS
IPC分类号： C07D498/18 , A61P37/06
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
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公开(公告)号：US20220339168A1
公开(公告)日：2022-10-27
申请号：US17753936
申请日：2020-09-21
申请人： Monash University
发明人： Natalie TREVASKIS , Christopher John PORTER , Tim QUACH , Sifei HAN , Enyuan CAO , Luojuan HU , Matthew WATT
IPC分类号： A61K31/635 , A61K31/404 , A61P3/04
摘要： The present invention provides methods of treating metabolic diseases including obesity, insulin resistance and type 2 diabetes with inhibitors of COX-2 or VEGFR and lipid prodrugs of COX-2 inhibitors, in particular celecoxib lipid prodrugs, that promote transport of the pharmaceutical agent to the lymphatic system and which enhance release of the parent agent.
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公开(公告)号：US20210268115A1
公开(公告)日：2021-09-02
申请号：US17169371
申请日：2021-02-05
发明人： Daniel Kenneth BONNER , Rishab R. SHYAM , Jamie SIMPSON , Christopher John PORTER , Natalie TREVASKIS , Tim QUACH , Sifei HAN , Luojuan HU
IPC分类号： A61K47/55 , A61K9/00 , A61K31/573
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
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