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1.发明授权Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants 失效被氨基酸和羟基酸衍生物取代的苄脒衍生物及其作为抗凝剂的用途公开(公告)号：US06242454B1
公开(公告)日：2001-06-05
申请号：US09393198
申请日：1999-09-09
申请人： Monica Kochanny , Raju Mohan , Michael M. Morrissey , Howard P. Ng , Weiya Yun
发明人： Monica Kochanny , Raju Mohan , Michael M. Morrissey , Howard P. Ng , Weiya Yun
IPC分类号： A61K31505
CPC分类号： C07D401/12
摘要： This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
摘要翻译： 本发明涉及由用作抗凝剂的氨基酸和羟基酸衍生物取代的苯甲脒衍生物。 本发明还涉及含有本发明化合物的药物组合物，以及使用该化合物治疗以血栓形成活性为特征的疾病状态的方法。
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公开(公告)号：US6166088A
公开(公告)日：2000-12-26
申请号：US393180
申请日：1999-09-09
申请人： Monica Kochanny , Raju Mohan , Michael M. Morrissey , Howard P. Ng , Weiya Yun
发明人： Monica Kochanny , Raju Mohan , Michael M. Morrissey , Howard P. Ng , Weiya Yun
IPC分类号： C07D213/60 , A61K31/00 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61P7/00 , A61P7/02 , C07C43/20 , C07C257/18 , C07D401/12 , C07D401/14 , A61K31/155
CPC分类号： C07D401/12
摘要： This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
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3.发明授权Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants 失效被氨基酸和羟基酸衍生物取代的苄脒衍生物及其作为抗凝剂的用途
公开(公告)号：US6071912A
公开(公告)日：2000-06-06
申请号：US394458
申请日：1999-09-09
申请人： Monica Kochanny , Raju Mohan , Michael M. Morrissey , Howard P. Ng , Weiya Yun
发明人： Monica Kochanny , Raju Mohan , Michael M. Morrissey , Howard P. Ng , Weiya Yun
IPC分类号： C07D213/60 , A61K31/00 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61P7/00 , A61P7/02 , C07C43/20 , C07C257/18 , C07D401/12 , C07D401/14 , A61K31/53 , C07D251/26
CPC分类号： C07D401/12
摘要： This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
摘要翻译： 本发明涉及由用作抗凝剂的氨基酸和羟基酸衍生物取代的苯甲脒衍生物。 本发明还涉及含有本发明化合物的药物组合物，以及使用该化合物治疗以血栓形成活性为特征的疾病状态的方法。
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公开(公告)号：US5994375A
公开(公告)日：1999-11-30
申请号：US599834
申请日：1996-02-12
IPC分类号： C07D213/60 , A61K31/00 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61P7/00 , A61P7/02 , C07C43/20 , C07C257/18 , C07D401/12 , C07D401/14 , C07D401/10
CPC分类号： C07D401/12
摘要： This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
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5.发明授权Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants 失效由环状氨基酸和环状羟基酸衍生物取代的苄脒衍生物及其作为抗凝剂的用途
公开(公告)号：US6008234A
公开(公告)日：1999-12-28
申请号：US920319
申请日：1997-08-27
IPC分类号： C07D401/12 , C07D401/14 , C07D417/14 , A01N43/40 , C07D211/72 , C07D401/00 , C07D403/00
CPC分类号： C07D401/12 , C07D401/14 , C07D417/14
摘要： This invention is directed to benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
摘要翻译： 本发明涉及用作抗凝血剂的环状氨基酸和环状羟基酸衍生物取代的苯甲脒衍生物。 本发明还涉及含有本发明化合物的药物组合物，以及使用该化合物治疗以血栓形成活性为特征的疾病状态的方法。
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6.发明授权Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatves and their use as anti-coagulants 失效由环状氨基酸和环状羟基酸衍生物取代的苄脒衍生物及其作为抗凝剂的用途公开(公告)号：US06232325B1
公开(公告)日：2001-05-15
申请号：US09438354
申请日：1999-11-12
IPC分类号： A61K3445
CPC分类号： C07D401/12 , C07D401/14 , C07D417/14
摘要： This invention is directed to benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
摘要翻译： 本发明涉及用作抗凝血剂的环状氨基酸和环状羟基酸衍生物取代的苯甲脒衍生物。 本发明还涉及含有本发明化合物的药物组合物，以及使用该化合物治疗以血栓形成活性为特征的疾病状态的方法。
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公开(公告)号：US06177473B1
公开(公告)日：2001-01-23
申请号：US09439065
申请日：1999-11-12
IPC分类号： A01N3302
CPC分类号： C07D401/12 , C07D401/14 , C07D417/14
摘要： This invention is directed to benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
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8.发明授权Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants 失效由环状氨基酸和环状羟基酸衍生物取代的苄脒衍生物及其作为抗凝剂的用途公开(公告)号：US06265404B1
公开(公告)日：2001-07-24
申请号：US09438270
申请日：1999-11-12
IPC分类号： A61K3153
CPC分类号： C07D401/12 , C07D401/14 , C07D417/14
摘要： This invention is directed to benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
摘要翻译： 本发明涉及用作抗凝血剂的环状氨基酸和环状羟基酸衍生物取代的苯甲脒衍生物。 本发明还涉及含有本发明化合物的药物组合物，以及使用该化合物治疗以血栓形成活性为特征的疾病状态的方法。
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公开(公告)号：US06995156B2
公开(公告)日：2006-02-07
申请号：US10947635
申请日：2004-09-22
申请人： Judi A. Bryant , Brad O. Buckman , Imadul Islam , Raju Mohan , Michael M. Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
发明人： Judi A. Bryant , Brad O. Buckman , Imadul Islam , Raju Mohan , Michael M. Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
IPC分类号： A61K31/496 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
CPC分类号： C07D295/205 , C07D215/48 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Compounds of the following formula (I): where a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译： 下式（I）的化合物：化学式id =“CHEM-US-00001”num =“000
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公开(公告)号：US07268140B2
公开(公告)日：2007-09-11
申请号：US11248618
申请日：2005-10-13
申请人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
发明人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
IPC分类号： A61K31/4965 , C07D241/04
CPC分类号： C07D295/185 , C07D215/18 , C07D241/04 , C07D241/38 , C07D261/14 , C07D295/192 , C07D307/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要： This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
摘要翻译： 本发明涉及可用作抗炎剂的酰基哌嗪衍生物。 本发明还涉及含有本发明化合物的药物组合物，以及使用该化合物治疗人类炎性疾病的方法。
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