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    Waveguide with integrated lens
    5.
    发明授权
    Waveguide with integrated lens 有权
    波导与集成镜头

    公开(公告)号：US08300993B2

    公开(公告)日：2012-10-30

    申请号：US12617535

    申请日：2009-11-12

    申请人： Kevin D. Moll ,  Kurt R. Vogel ,  Marie J. Delaney ,  Michael J. Lochhead ,  Christopher J. Myatt

    发明人： Kevin D. Moll ,  Kurt R. Vogel ,  Marie J. Delaney ,  Michael J. Lochhead ,  Christopher J. Myatt

    IPC分类号： G02B6/12

    CPC分类号： G01N21/552 ,  G02B6/12004 ,  G02B6/4206 ,  G02B2006/12102

    摘要： A sample can be illuminated for analysis using apparatus including a light source, a planar waveguide, and a refractive volume. The light source provides light along a propagation vector. The planar waveguide is oriented such that the propagation vector is perpendicular to the normal vector of the planar waveguide and offset from the planar waveguide in a direction parallel to the normal vector of the planar waveguide. The refractive volume is positioned proximate to the planar waveguide and can optically coupling light provided by the light source to the planar waveguide.

    摘要翻译： 可以使用包括光源，平面波导和折射体积的装置照亮样品进行分析。 光源沿着传播矢量提供光。 平面波导取向为使得传播矢量垂直于平面波导的法线向量并且平行于平面波导的方向平行于平面波导的法向矢量。 折射体积位于平面波导附近，并且可将由光源提供的光光学耦合到平面波导。

    Waveguide With Integrated Lens
    6.
    发明申请
    Waveguide With Integrated Lens 有权
    波导与集成镜头

    公开(公告)号：US20100220318A1

    公开(公告)日：2010-09-02

    申请号：US12617535

    申请日：2009-11-12

    申请人： Kevin D. Moll ,  Kurt R. Vogel ,  Marie J. Delaney ,  Michael J. Lochhead ,  Christopher I. Myatt

    发明人： Kevin D. Moll ,  Kurt R. Vogel ,  Marie J. Delaney ,  Michael J. Lochhead ,  Christopher I. Myatt

    IPC分类号： G01N21/41 ,  G02B6/32

    CPC分类号： G01N21/552 ,  G02B6/12004 ,  G02B6/4206 ,  G02B2006/12102

    摘要： A sample can be illuminated for analysis using apparatus including a light source, a planar waveguide, and a refractive volume. The light source provides light along a propagation vector. The planar waveguide is oriented such that the propagation vector is perpendicular to the normal vector of the planar waveguide and offset from the planar waveguide in a direction parallel to the normal vector of the planar waveguide. The refractive volume is positioned proximate to the planar waveguide and can optically coupling light provided by the light source to the planar waveguide.

    摘要翻译： 可以使用包括光源，平面波导和折射体积的装置照亮样品进行分析。 光源沿着传播矢量提供光。 平面波导取向为使得传播矢量垂直于平面波导的法线向量并且平行于平面波导的方向平行于平面波导的法向矢量。 折射体积位于平面波导附近，并且可将由光源提供的光光学耦合到平面波导。

    Integrated sample preparation and analyte detection
    7.
    发明授权
    Integrated sample preparation and analyte detection 有权
    综合样品制备和分析物检测

    公开(公告)号：US08697435B2

    公开(公告)日：2014-04-15

    申请号：US12871402

    申请日：2010-08-30

    申请人： James R. Heil ,  Michael J. Lochhead ,  Kevin D. Moll ,  Christopher J. Myatt

    发明人： James R. Heil ,  Michael J. Lochhead ,  Kevin D. Moll ,  Christopher J. Myatt

    IPC分类号： C12M1/34 ,  G01N33/543

    CPC分类号： G01N33/54326 ,  G01N33/54373 ,  G01N33/585 ,  Y10S435/808 ,  Y10S436/805 ,  Y10S436/806

    摘要： A system for sample preparation and analyte detection includes a cartridge, with a fluidic channel, a waveguide, and a capture spot. The system further includes a force field generator, an imaging system, and a fluid, which includes a sample potentially containing a target analyte, first type particles, which include binding moieties specific for the target analyte and are responsive to a force field, and second type particles, which include binding moieties specific for the target analyte and are capable of generating a signal. When the sample contains the target analyte, specific binding interactions between the target analyte and binding moieties link first and second type particles via the target analyte to form multiple-particle complex capturable at a capture spot. The force field allows manipulation of the particles and multiple-particle complex such that the detected signal from the second type particles is indicative of the target analyte within the sample.

    摘要翻译： 用于样品制备和分析物检测的系统包括具有流体通道，波导和捕获点的盒。 该系统还包括力场发生器，成像系统和流体，其包括潜在地包含目标分析物的样品，第一类型颗粒，其包括对于目标分析物特异的并且对力场有反应的结合部分，并且第二 型颗粒，其包括对目标分析物特异性的结合部分并且能够产生信号。 当样品含有目标分析物时，目标分析物和结合部分之间的特异性结合相互作用通过目标分析物连接第一和第二类型颗粒，以在捕捉点处形成可以捕获的多重颗粒复合物。 力场允许操作颗粒和多颗粒复合物，使得来自第二类型颗粒的检测信号指示样品内的目标分析物。

    Integrated Sample Preparation and Analyte Detection
    8.
    发明申请
    Integrated Sample Preparation and Analyte Detection 有权
    综合样品制备和分析物检测

    公开(公告)号：US20110065209A1

    公开(公告)日：2011-03-17

    申请号：US12871402

    申请日：2010-08-30

    申请人： James R. Heil ,  Michael J. Lochhead ,  Kevin D. Moll ,  Christopher J. Myatt

    发明人： James R. Heil ,  Michael J. Lochhead ,  Kevin D. Moll ,  Christopher J. Myatt

    IPC分类号： G01N33/53 ,  G01N30/96

    CPC分类号： G01N33/54326 ,  G01N33/54373 ,  G01N33/585 ,  Y10S435/808 ,  Y10S436/805 ,  Y10S436/806

    摘要： A system for sample preparation and analyte detection includes a cartridge, with a fluidic channel, a waveguide, and a capture spot. The system further includes a force field generator, an imaging system, and a fluid, which includes a sample potentially containing a target analyte, first type particles, which include binding moieties specific for the target analyte and are responsive to a force field, and second type particles, which include binding moieties specific for the target analyte and are capable of generating a signal. When the sample contains the target analyte, specific binding interactions between the target analyte and binding moieties link first and second type particles via the target analyte to form multiple-particle complex capturable at a capture spot. The force field allows manipulation of the particles and multiple-particle complex such that the detected signal from the second type particles is indicative of the target analyte within the sample.

    摘要翻译： 用于样品制备和分析物检测的系统包括具有流体通道，波导和捕获点的盒。 该系统还包括力场发生器，成像系统和流体，其包括潜在地包含目标分析物的样品，第一类型颗粒，其包括对于目标分析物特异的并且对力场有反应的结合部分，并且第二 型颗粒，其包括对目标分析物特异性的结合部分并且能够产生信号。 当样品含有目标分析物时，目标分析物和结合部分之间的特异性结合相互作用通过目标分析物连接第一和第二类型颗粒，以在捕捉点处形成可以捕获的多重颗粒复合物。 力场允许操作颗粒和多颗粒复合物，使得来自第二类型颗粒的检测信号指示样品内的目标分析物。

    PLANAR OPTICAL WAVEGUIDE WITH CORE OF LOW-INDEX-OF-REFRACTION INTERROGATION MEDIUM
    9.
    发明申请
    PLANAR OPTICAL WAVEGUIDE WITH CORE OF LOW-INDEX-OF-REFRACTION INTERROGATION MEDIUM 有权
    具有低折射介质介质核心的平面光波导

    公开(公告)号：US20110049388A1

    公开(公告)日：2011-03-03

    申请号：US12942234

    申请日：2010-11-09

    申请人： Marie J. Delaney ,  Kevin D. Moll

    发明人： Marie J. Delaney ,  Kevin D. Moll

    IPC分类号： G01J1/58 ,  G02B6/32

    CPC分类号： G01N21/552 ,  G02B6/124 ,  G02B6/4206

    摘要： An apparatus for illuminating a sample includes a planar waveguide. The planar waveguide includes a first substrate, including a first outer surface and a first inner surface, and a second substrate, including a second outer surface and a second inner surface. The first and second inner surfaces of the first and second substrates, respectively, are spaced apart from each other and partly define a volume for confining the sample therein. The apparatus also includes a light source for providing light directed toward the planar waveguide, such that the light is optically coupled to and contained within the planar waveguide between the outer surfaces of the first and second substrates, while illuminating at least a portion of the sample confined within the volume.

    摘要翻译： 用于照射样品的装置包括平面波导。 平面波导包括包括第一外表面和第一内表面的第一基板和包括第二外表面和第二内表面的第二基板。 第一和第二基板的第一和第二内表面分别彼此分开，并且部分地限定用于将样品限制在其中的体积。 该装置还包括用于提供朝向平面波导的光的光源，使得光在第一和第二基板的外表面之间光耦合到平面波导内并且包含在平面波导内，同时照亮样品的至少一部分 限于卷内。

    Planar optical waveguide with core of low-index-of-refraction interrogation medium
    10.
    发明授权
    Planar optical waveguide with core of low-index-of-refraction interrogation medium 有权
    具有低折射率询问介质核的平面光波导

    公开(公告)号：US08331751B2

    公开(公告)日：2012-12-11

    申请号：US12942234

    申请日：2010-11-09

    申请人： Marie J. Delaney ,  Kevin D. Moll

    发明人： Marie J. Delaney ,  Kevin D. Moll

    IPC分类号： G02B6/10

    CPC分类号： G01N21/552 ,  G02B6/124 ,  G02B6/4206

    摘要： An apparatus for illuminating a sample includes a planar waveguide. The planar waveguide includes a first substrate, including a first outer surface and a first inner surface, and a second substrate, including a second outer surface and a second inner surface. The first and second inner surfaces of the first and second substrates, respectively, are spaced apart from each other and partly define a volume for confining the sample therein. The apparatus also includes a light source for providing light directed toward the planar waveguide, such that the light is optically coupled to and contained within the planar waveguide between the outer surfaces of the first and second substrates, while illuminating at least a portion of the sample confined within the volume.

    摘要翻译： 用于照射样品的装置包括平面波导。 平面波导包括包括第一外表面和第一内表面的第一基板和包括第二外表面和第二内表面的第二基板。 第一和第二基板的第一和第二内表面分别彼此间隔开，并且部分地限定用于将样品限制在其中的体积。 该装置还包括用于提供朝向平面波导的光的光源，使得光在第一和第二基板的外表面之间光耦合到平面波导内并且包含在平面波导内，同时照亮样品的至少一部分 限于卷内。