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1.发明申请公开(公告)号：US20090221441A1
公开(公告)日：2009-09-03
申请号：US12091990
申请日：2006-10-31
CPC分类号： G01N33/5014 , B01J19/0046 , B01J2219/00387 , B01J2219/00527 , B01J2219/0065 , B01J2219/00659 , B01J2219/00664 , B01J2219/00743 , C12N2503/00 , C12N2533/54
摘要： The present invention is directed to a screening platform employing a miniaturized three-dimensional cell chip for high-throughput toxicology screening of test and lead compounds, prodrugs, drugs and P-450 generated drug metabolites. To this end, the three-dimensional cell chip, employs human cells encapsulated in a matrix (e.g., collagen or alginate gels) in volumes as small as 10 nL arrayed on a functionalized substrates (e.g., glass microscope slides) for spatially addressable screening against multiple test compounds. With the present platform, over 3,000 cell-matrix islands may be spotted providing for simultaneous screening against multiple compounds at multiple doses and in high replicate.
摘要翻译： 本发明涉及采用小型化三维细胞芯片用于测试和引导化合物，前药，药物和P-450产生的药物代谢物的高通量毒理学筛选的筛选平台。 为此，三维细胞芯片采用封装在矩阵（例如，胶原或藻酸胶体）中的人体细胞，其体积小于排列在官能化底物（例如，玻璃显微镜载片）上的10nL，用于空间可寻址筛选 多种试验化合物。 利用目前的平台，可以发现超过3,000个细胞基质岛可以同时筛选多个剂量的多种化合物和高度复制。
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2.发明申请MICROBIAL TESTING DEVICES, METHODS OF MAKING MICROBIAL TESTING DEVICES AND METHODS OF IDENTIFYING NOVEL ANTIMICROBIAL DRUG CANDIDATES 审中-公开微生物测试装置，制备微生物测试装置的方法和鉴定新型抗微生物药物候选药物的方法公开(公告)号：US20150167046A1
公开(公告)日：2015-06-18
申请号：US14603873
申请日：2015-01-23
IPC分类号： C12Q1/18
CPC分类号： C12Q1/18 , G01N33/56961
摘要： The present disclosure provides for microbial testing devices, methods for making microbial testing devices, methods for growing and testing microbial cultures and methods for testing compounds for antimicrobial activity.
摘要翻译： 本公开提供了微生物测试装置，用于制备微生物测试装置的方法，用于生长和测试微生物培养物的方法以及用于测试抗微生物活性化合物的方法。
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3.发明授权Development of a high-throughput screen for the identification of novel antifungal drug candidates 有权开发用于鉴定新型抗真菌药物候选物的高通量筛选公开(公告)号：US08962531B2
公开(公告)日：2015-02-24
申请号：US13522446
申请日：2011-01-14
IPC分类号： C40B30/06 , C40B50/06 , C40B40/02 , G01N33/569
CPC分类号： C12Q1/18 , G01N33/56961
摘要： In one embodiment, a testing device includes a substrate and a plurality of spatially distinct fungal cultures disposed on the substrate.
摘要翻译： 在一个实施例中，测试装置包括衬底和设置在衬底上的多个空间不同的真菌培养物。
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公开(公告)号：US10577638B2
公开(公告)日：2020-03-03
申请号：US15023568
申请日：2014-09-23
IPC分类号： C12Q1/18
摘要： The present disclosure provides for systems, devices, products, and methods for detecting and identifying microbial organisms in a sample as well as testing antimicrobial susceptibility of microbial organisms.
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5.发明申请SYSTEMS, DEVICES, & METHODS FOR MICROBIAL DETECTION & IDENTIFICATION, AND ANTIMICROBIAL SUSCEPTIBILITY TESTING 审中-公开用于微生物检测和鉴定的系统，设备和方法以及抗微生物的可检测性公开(公告)号：US20160215324A1
公开(公告)日：2016-07-28
申请号：US15023568
申请日：2014-09-23
IPC分类号： C12Q1/18
CPC分类号： C12Q1/18
摘要： The present disclosure provides for systems, devices, products, and methods for detecting and identifying microbial organisms in a sample as well as testing antimicrobial susceptibility of microbial organisms.
摘要翻译： 本公开提供用于检测和鉴定样品中微生物生物体的系统，装置，产品和方法以及测试微生物生物的抗微生物敏感性。
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6.发明申请DEVELOPMENT OF A HIGH-THROUGHPUT SCREEN FOR THE IDENTIFICATION OF NOVEL ANTIFUNGAL DRUG CANDIDATES 有权开发用于鉴定新型抗真菌药物候选药物的高通量筛选公开(公告)号：US20130040854A1
公开(公告)日：2013-02-14
申请号：US13522446
申请日：2011-01-14
CPC分类号： C12Q1/18 , G01N33/56961
摘要： In one embodiment, a testing device includes a substrate and a plurality of spatially distinct fungal cultures disposed on the substrate.
摘要翻译： 在一个实施例中，测试装置包括衬底和设置在衬底上的多个空间不同的真菌培养物。
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