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公开(公告)号：US20120165224A1
公开(公告)日：2012-06-28
申请号：US13335182
申请日：2011-12-22
申请人： Suk Ho SONG , Bo Sung Ku , Se Hoon Jeong , Moo Yeal Lee , Dong Woo Lee
发明人： Suk Ho SONG , Bo Sung Ku , Se Hoon Jeong , Moo Yeal Lee , Dong Woo Lee
IPC分类号： C40B40/00
CPC分类号： B01J19/0046 , B01J2219/00619 , B01J2219/00637 , B01J2219/00644 , B01J2219/00743 , C40B60/12
摘要： Disclosed herein is a cell chip including: an upper substrate having a plurality of biometrics spaced therefrom by fillers, the biometrics fixing a biomaterial thereinto; a first hydrophobic coating layer formed on the upper substrate; and a lower substrate combined with the upper substrate and having a plurality of wells formed therein, the well storing fluid provided to the biometrics therein. The cell chip includes two substrates functionally separated from each other to implement a three dimensional cell chip, solves a cross contamination problem, and provides a similar environment to a bio environment, thereby making it possible to increase the accuracy of a test.
摘要翻译： 本文公开了一种细胞芯片，包括：上基板，其具有多个通过填料与其间隔开的生物特征，生物测定法将生物材料固定在其中; 形成在上基板上的第一疏水涂层; 以及与上基板结合并具有形成在其中的多个井的下基板，所述井存储提供给其中的生物特征的流体。 电池芯片包括彼此功能分离以实现三维电池芯片的两个基板，解决交叉污染问题，并且为生物环境提供类似的环境，从而可以提高测试的准确性。
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公开(公告)号：US20140227145A1
公开(公告)日：2014-08-14
申请号：US13821928
申请日：2012-05-17
申请人： Sang Jin Kim , Suk-ho Song , Bo Sung Ku , Moo-Yeal Lee
发明人： Sang Jin Kim , Suk-ho Song , Bo Sung Ku , Moo-Yeal Lee
IPC分类号： B01L3/02
CPC分类号： B01L3/0293 , B01L3/0268 , B01L2300/0867 , B01L2300/14 , B01L2400/0487 , G01F11/02
摘要： There is provided a fluid discharging device including: a first pressure generating unit generating a first pressure for discharging a fluid; a second pressure generating unit generating a second pressure for discharging a fluid, and being controllable so as to change a magnitude of the second pressure; and a nozzle discharging the fluid pressurized by the first and second pressure generating units.
摘要翻译： 提供了一种流体排放装置，包括：第一压力产生单元，其产生用于排出流体的第一压力; 第二压力产生单元，其产生用于排出流体的第二压力，并且可控制以改变第二压力的大小; 以及喷嘴，排出由第一和第二压力发生单元加压的流体。
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公开(公告)号：US20070000781A1
公开(公告)日：2007-01-04
申请号：US10351976
申请日：2003-01-24
申请人： Jonathan Dordick , Moo-Yeal Lee , Aravind Srinivasan , Bosung Ku
发明人： Jonathan Dordick , Moo-Yeal Lee , Aravind Srinivasan , Bosung Ku
CPC分类号： C07K17/14
摘要： Disclosed herein is a method and apparatus of immobilizing a biocatalyst on a microfluidic biochip for conducting reactions in the presence of electroosmotic flow. The biochip includes a polymer on its microfluidic flow surfaces, wherein the polymer includes a first substituent selected from ionic groups of the same polarity or precursors thereof, a second substituent that is a hydrophobic group, and a third substituent comprising an immobilized biocatalyst- or precursor thereof. The biochip can be used to conduct multiple sequential biocatalyzed reactions in the presence of electroosmotic flow.
摘要翻译： 本文公开了将生物催化剂固定在微流体生物芯片上以在存在电渗流的情况下进行反应的方法和装置。 生物芯片包括其微流体流动表面上的聚合物，其中聚合物包括选自相同极性的离子基团的第一取代基或其前体，作为疏水基团的第二取代基，和包含固定的生物催化剂或前体的第三取代基 其中。 生物芯片可用于在电渗流的存在下进行多次连续的生物催化反应。
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公开(公告)号：US20120088693A1
公开(公告)日：2012-04-12
申请号：US13228668
申请日：2011-09-09
申请人： Moo-Yeal Lee , Dong Woo Lee , Se Hoon Jeong , Jeong Suong Yang , Bo Sung Ku
发明人： Moo-Yeal Lee , Dong Woo Lee , Se Hoon Jeong , Jeong Suong Yang , Bo Sung Ku
IPC分类号： C40B40/04
CPC分类号： C12M23/12 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/00644 , B01J2219/0065 , B01J2219/00659 , B01J2219/00743 , C40B30/06
摘要： Disclosed herein is a microarray cell chip. The microarray cell chip includes an upper substrate that has biomatrices encapsulating biomaterials formed on one surface thereof and through holes penetrating from one surface to the other surface thereof and a lower substrate that is coupled with the upper substrate and is provided with wells storing reagents supplied to the biomatrices. The microarray cell chip according to the present invention can smoothly transfer the culture media and the reagents to the biomaterials embedded in the biomatrices through the diffusion and simply separate the upper substrate from the lower substrate, thereby improving the easiness of washing. Therefore, the present invention provides an environment similar to the bio environment, thereby making it possible to increase accuracy of an experiment.
摘要翻译： 本文公开了一种微阵列细胞芯片。 微阵列电池芯片包括上基板，其具有密封在其一个表面上形成的生物材料的生物基质，以及穿透从一个表面到另一个表面的孔，以及与上基板结合的下基板，并且设置有储存试剂的孔 生物基因。 根据本发明的微阵列芯片可以通过扩散将培养基和试剂顺利地转移到嵌入在生物基质中的生物材料，并且简单地将上基底与下基底分离，从而提高洗涤的容易性。 因此，本发明提供与生物环境相似的环境，从而可以提高实验的准确性。
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公开(公告)号：US20070108057A1
公开(公告)日：2007-05-17
申请号：US11651269
申请日：2007-01-09
申请人： Jonathan Dordick , Moo-Yeal Lee , Aravind Srinivasan , Bosung Ku
发明人： Jonathan Dordick , Moo-Yeal Lee , Aravind Srinivasan , Bosung Ku
IPC分类号： G01N27/00
CPC分类号： C07K17/14
摘要： Disclosed herein is a method and apparatus of immobilizing a biocatalyst on a microfluidic biochip for conducting reactions in the presence of electroosmotic flow. The biochip includes a polymer on its microfluidic flow surfaces, wherein the polymer includes a first substituent selected from ionic groups of the same polarity or precursors thereof, a second substituent that is a hydrophobic group, and a third substituent comprising an immobilized biocatalyst-or precursor thereof. The biochip can be used to conduct multiple sequential biocatalyzed reactions in the presence of electroosmotic flow.
摘要翻译： 本文公开了将生物催化剂固定在微流体生物芯片上以在存在电渗流的情况下进行反应的方法和装置。 生物芯片包括在其微流体流动表面上的聚合物，其中聚合物包括选自相同极性的离子基团的第一取代基或其前体，作为疏水基团的第二取代基和包含固定的生物催化剂或前体的第三取代基 其中。 生物芯片可用于在电渗流的存在下进行多次连续的生物催化反应。
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6.发明申请公开(公告)号：US20110190162A1
公开(公告)日：2011-08-04
申请号：US12945214
申请日：2010-11-12
摘要： The invention is directed to a three-dimensional cell culture array comprising spatially-separated matrices attached to a solid support, wherein a plurality of said matrices encapsulate cells transfected with nucleic acids, method for the preparation of the array and methods reducing the expression of a target gene.
摘要翻译： 本发明涉及一种三维细胞培养阵列，其包含连接到固体支持物的空间分离的基质，其中多个所述基质包封用核酸转染的细胞，用于制备阵列的方法和减少 靶基因。
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7.发明申请公开(公告)号：US20090221441A1
公开(公告)日：2009-09-03
申请号：US12091990
申请日：2006-10-31
CPC分类号： G01N33/5014 , B01J19/0046 , B01J2219/00387 , B01J2219/00527 , B01J2219/0065 , B01J2219/00659 , B01J2219/00664 , B01J2219/00743 , C12N2503/00 , C12N2533/54
摘要： The present invention is directed to a screening platform employing a miniaturized three-dimensional cell chip for high-throughput toxicology screening of test and lead compounds, prodrugs, drugs and P-450 generated drug metabolites. To this end, the three-dimensional cell chip, employs human cells encapsulated in a matrix (e.g., collagen or alginate gels) in volumes as small as 10 nL arrayed on a functionalized substrates (e.g., glass microscope slides) for spatially addressable screening against multiple test compounds. With the present platform, over 3,000 cell-matrix islands may be spotted providing for simultaneous screening against multiple compounds at multiple doses and in high replicate.
摘要翻译： 本发明涉及采用小型化三维细胞芯片用于测试和引导化合物，前药，药物和P-450产生的药物代谢物的高通量毒理学筛选的筛选平台。 为此，三维细胞芯片采用封装在矩阵（例如，胶原或藻酸胶体）中的人体细胞，其体积小于排列在官能化底物（例如，玻璃显微镜载片）上的10nL，用于空间可寻址筛选 多种试验化合物。 利用目前的平台，可以发现超过3,000个细胞基质岛可以同时筛选多个剂量的多种化合物和高度复制。
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公开(公告)号：US07172682B2
公开(公告)日：2007-02-06
申请号：US10351976
申请日：2003-01-24
IPC分类号： C07K17/14
CPC分类号： C07K17/14
摘要： Disclosed herein is a method and apparatus of immobilizing a biocatalyst on a microfluidic biochip for conducting reactions in the presence of electroosmotic flow. The biochip includes a polymer on its microfluidic flow surfaces, wherein the polymer includes a first substituent selected from ionic groups of the same polarity or precursors thereof, a second substituent that is a hydrophobic group, and a third substituent comprising an immobilized biocatalyst-or precursor thereof. The biochip can be used to conduct multiple sequential biocatalyzed reactions in the presence of electroosmotic flow.
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