公开(公告)号：US20100113556A1

公开(公告)日：2010-05-06

申请号：US12449867

申请日：2008-03-03

申请人： Moon Sung Kim ,  Moo Hi Yoo ,  Jae Keol Rhee ,  Yong Jik Kim ,  Seong Jin Park ,  Jun Ho Choi ,  Si Young Sung ,  Hong Gyu Lim ,  Dae Won Cha

发明人： Moon Sung Kim ,  Moo Hi Yoo ,  Jae Keol Rhee ,  Yong Jik Kim ,  Seong Jin Park ,  Jun Ho Choi ,  Si Young Sung ,  Hong Gyu Lim ,  Dae Won Cha

IPC分类号： A61K31/40 ,  C07D207/30 ,  A61P3/06

CPC分类号： C07D207/34

摘要： The present invention provides novel crystalline forms D1 and D2 of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt, and hydrates thereof. The crystalline forms D1 and D2 have X-ray powder diffraction peaks described in FIGS. 1 and 3, respectively. Further, the present invention provides processes for preparing the crystalline forms and pharmaceutical compositions comprising the crystalline forms. The crystalline forms can be produced on a commercial scale and exhibit excellent stability.

摘要翻译： 本发明提供了[R-（R *，R *）] - 2-（4-氟苯基） - ，β-二羟基-5-（1-甲基乙基）-3-苯基 - 4 - [（苯基氨基）羰基] -1H-吡咯-1-庚酸半钙盐及其水合物。 结晶形式D1和D2具有图1和2所述的X射线粉末衍射峰。 1和3。 此外，本发明提供了制备结晶形式的方法和包含结晶形式的药物组合物。 结晶形式可以以商业规模生产并且表现出优异的稳定性。

公开(公告)号：US07915302B2

公开(公告)日：2011-03-29

申请号：US12449867

申请日：2008-03-03

申请人： Moon Sung Kim ,  Moo Hi Yoo ,  Jae Keol Rhee ,  Yong Jik Kim ,  Seong Jin Park ,  Jun Ho Choi ,  Si Young Sung ,  Hong Gyu Lim ,  Dae Won Cha

发明人： Moon Sung Kim ,  Moo Hi Yoo ,  Jae Keol Rhee ,  Yong Jik Kim ,  Seong Jin Park ,  Jun Ho Choi ,  Si Young Sung ,  Hong Gyu Lim ,  Dae Won Cha

IPC分类号： A61K31/40 ,  C07D207/30

CPC分类号： C07D207/34

摘要： The present invention provides novel crystalline forms D1 and D2 of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt, and hydrates thereof. The crystalline forms D1 and D2 have X-ray powder diffraction peaks described in FIGS. 1 and 3, respectively. Further, the present invention provides processes for preparing the crystalline forms and pharmaceutical compositions comprising the crystalline forms. The crystalline forms can be produced on a commercial scale and exhibit excellent stability.

摘要翻译： 本发明提供了[R-（R *，R *）] - 2-（4-氟苯基） - ，β-二羟基-5-（1-甲基乙基）-3-苯基 - 4 - [（苯基氨基）羰基] -1H-吡咯-1-庚酸半钙盐及其水合物。 结晶形式D1和D2具有图1和2所述的X射线粉末衍射峰。 1和3。 此外，本发明提供了制备结晶形式的方法和包含结晶形式的药物组合物。 结晶形式可以以商业规模生产并且表现出优异的稳定性。

公开(公告)号：US09617623B2

公开(公告)日：2017-04-11

申请号：US14235616

申请日：2012-07-26

申请人： Si Young Sung ,  Beom Suck Han

发明人： Si Young Sung ,  Beom Suck Han

IPC分类号： C22F1/04 ,  B22D21/04 ,  C22C21/00 ,  B22D17/00 ,  C22C21/02 ,  C22C21/08 ,  C22C1/02 ,  B22D21/00

CPC分类号： C22C21/00 ,  B22D17/00 ,  B22D21/007 ,  C22C1/026 ,  C22C21/02 ,  C22C21/08

摘要： Provided are an aluminum alloy including an iron-manganese complete solid solution and a method of manufacturing the same. According to an embodiment of the present invention, iron-manganese alloy powder is provided. The iron-manganese alloy powder is introduced into an aluminum melt. An aluminum alloy including an iron-manganese complete solid solution is manufactured by die casting the aluminum melt.

公开(公告)号：US20130236351A1

公开(公告)日：2013-09-12

申请号：US13988940

申请日：2011-11-21

申请人： Si Young Sung ,  Beom Suck Han

发明人： Si Young Sung ,  Beom Suck Han

IPC分类号： C22C21/06 ,  C22C23/02 ,  B22D25/00

CPC分类号： C22C21/06 ,  B22D21/007 ,  B22D25/00 ,  C22C1/03 ,  C22C23/02

摘要： Provided are an extruded aluminum (Al)-magnesium (Mg) material and a method of producing the same. An Al—Mg master alloy having a first Mg content is provided. An Al—Mg alloy having a second Mg content less than the first Mg content is prepared by adding the Al—Mg master alloy into molten Al and then casting the molten Al. An extruded Al—Mg material is prepared by extruding the Al—Mg alloy.

摘要翻译： 提供挤出的铝（Al） - 镁（Mg）材料及其制备方法。 提供具有第一Mg含量的Al-Mg母合金。 通过将Al-Mg母合金加入到熔融Al中然后浇铸熔融的Al来制备具有比第一Mg含量低的第二Mg含量的Al-Mg合金。 通过挤出Al-Mg合金制备挤出的Al-Mg材料。

公开(公告)号：US20120020829A1

公开(公告)日：2012-01-26

申请号：US13146304

申请日：2010-01-25

申请人： Si Young Sung ,  Beom Suck Han ,  Young Jig Kim ,  Bong Jae Choi ,  Yung Mun Ryu ,  Dong Ok Kim ,  Sang Ho Noh ,  Chang Su Hahn

发明人： Si Young Sung ,  Beom Suck Han ,  Young Jig Kim ,  Bong Jae Choi ,  Yung Mun Ryu ,  Dong Ok Kim ,  Sang Ho Noh ,  Chang Su Hahn

IPC分类号： C22C21/12 ,  C22C21/00 ,  B22D25/00

CPC分类号： C22C21/12 ,  C21D6/00 ,  C21D2201/03 ,  C21D2211/004 ,  C22C1/03 ,  C22C21/00 ,  C22F1/04 ,  C22F1/057

摘要： Disclosed is a heat-resistant aluminum alloy including aluminum and two types of alloy elements which are combined while forming a homogeneous solid solution reinforcing phase. The disclosed heat-resistant aluminum alloy includes the alloy elements that form a homogeneous solid solution and do not have a solvus line with respect to aluminum as a matrix metal and, therefore, the formed homogeneous solid solution reinforcing phase does not react with aluminum even at a temperature up to 300° C., thus not becoming coarse or undergoing phase decomposition. Consequently, the disclosed aluminum alloy may have remarkably enhanced heat resistance.

摘要翻译： 公开了一种耐热铝合金，其包括铝和两种类型的合金元素，其在形成均匀的固溶体增强相的同时组合。 所公开的耐热铝合金包括形成均匀固溶体并且相对于铝作为基质金属没有固溶线的合金元素，因此形成的均匀固溶体增强相不与铝反应，即使在 温度高达300℃，因此不会变粗或发生相分解。 因此，所公开的铝合金可以具有显着提高的耐热性。