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    Tablets quickly disintegrating in oral cavity
    4.
    发明申请
    Tablets quickly disintegrating in oral cavity 审中-公开
    片剂在口腔内迅速崩解

    公开(公告)号：US20050147666A1

    公开(公告)日：2005-07-07

    申请号：US10506349

    申请日：2003-03-06

    申请人： Motohiro Ohta ,  Yuji Iwase ,  Naohiro Saito ,  Kiyoshi Morimoto

    发明人： Motohiro Ohta ,  Yuji Iwase ,  Naohiro Saito ,  Kiyoshi Morimoto

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K31/22 ,  A61P3/06

    CPC分类号： A61K31/22 ,  A61K9/0056 ,  A61K9/2018

    摘要： According to the present invention, provided are an intraorally rapidly disintegrable tablet which comprises D-mannitol and a disintegrator in addition to fine granules prepared by granulating a mixture of a water-soluble pharmacologically active ingredient and an adsorbent; a process for producing an intraorally rapidly disintegrable tablet which comprises mixing D-mannitol and a disintegrator with fine granules prepared by granulating a mixture of a water-soluble pharmacologically active ingredient and an adsorbent to yield a material for compression molding, and subjecting the material to compression molding; and an intraorally rapidly disintegrable tablet which is prepared by mixing D-mannitol and a disintegrator with fine granules prepared by granulating a mixture of a water-soluble pharmacologically active ingredient and an adsorbent to yield a material for compression molding, subjecting the material to compression molding.

    摘要翻译： 根据本发明，提供了除了通过将水溶性药理活性成分和吸附剂的混合物制粒而制备的细颗粒以外还含有D-甘露糖醇和崩解剂的口腔内快速崩解片剂， 一种生产口腔内快速崩解片剂的方法，其包括将D-甘露糖醇和崩解剂与通过将水溶性药理学活性成分和吸附剂的混合物制粒而制备的细粒混合，得到压缩成型材料， 压缩成型; 以及通过将D-甘露糖醇和崩解剂与通过将水溶性药理活性成分和吸附剂的混合物制粒而制备的细颗粒混合而制备的口腔内快速崩解片剂，得到压缩成型材料，将其压缩成型 。

    Pulsating vibration air generation means
    6.
    发明授权
    Pulsating vibration air generation means 失效
    脉动振动空气产生装置

    公开(公告)号：US06607008B1

    公开(公告)日：2003-08-19

    申请号：US09869040

    申请日：2001-08-22

    申请人： Hirokazu Yoshimoto ,  Kiyoshi Morimoto ,  Yuji Iwase ,  Kazue Murata

    发明人： Hirokazu Yoshimoto ,  Kiyoshi Morimoto ,  Yuji Iwase ,  Kazue Murata

    IPC分类号： B06B118

    CPC分类号： F16K11/0525 ,  B06B1/18 ,  F26B3/0926 ,  F26B21/12 ,  G10K7/06 ,  Y10T137/86405

    摘要： Pulsating vibration air generation apparatus comprising a cylindrical casing having an air supply port connected with an air source and a wave transmission port provided at the circumferential surface thereof, and a drum type rotary valve constructed rotatably in the casing, wherein the air supply port is located where a circumferential surface of the rotary valve is positioned when the rotary valve is contained in the casing, the wave transmission port is located apart from where the circumferential surface of the rotary valve is positioned when the rotary valve is contained in the casing, the drum type rotary valve is comprised of a rotary support shaft at a center axis, one end of the rotary valve is opened, another end of the rotary valve is closed, at least one ventilation window is provided at the circumferential surface of the rotary valve, the rotary valve is contained in the casing in such a manner that the open end of the rotary valve faces to the wave transmission port of the casing, and the at least one ventilation window provided at the circumferential surface of the rotary valve is designed to intermittently meet the air supply port according to rotation of the valve when a rotary drive apparatus is connected with the rotary support shaft and the rotary drive apparatus is driven.

    摘要翻译： 脉冲振动空气产生装置，包括：具有与空气源连接的空气供给口的圆筒形壳体和设置在其圆周表面的波浪传送口;以及滚筒式旋转阀，其可旋转地构造在所述壳体中，其中所述空气供给口位于 当旋转阀被容纳在壳体中时旋转阀的圆周表面定位，当旋转阀被容纳在壳体中时，波传播口位于旋转阀的圆周表面位于其周围的位置，滚筒 旋转阀由中心轴线的旋转支撑轴构成，旋转阀的一端开口，旋转阀的另一端关闭，在旋转阀的圆周面上设置至少一个通风窗， 旋转阀以这样的方式容纳在壳体中，使得旋转阀的开口端面向th的波浪传输端口 并且设置在旋转阀的圆周表面处的至少一个通风窗被设计成当旋转驱动装置与旋转支撑轴和旋转驱动器连接时，根据阀的旋转间歇地与空气供应口相遇 装置被驱动。

    Production method and system for granulating powdered material
    7.
    发明授权
    Production method and system for granulating powdered material 失效
    造粒方法和制粉系统

    公开(公告)号：US06464737B1

    公开(公告)日：2002-10-15

    申请号：US09084919

    申请日：1998-05-28

    申请人： Kiyoshi Morimoto ,  Hirokazu Yoshimoto ,  Sanji Tokuno ,  Hiroshi Tada ,  Kazue Murata

    发明人： Kiyoshi Morimoto ,  Hirokazu Yoshimoto ,  Sanji Tokuno ,  Hiroshi Tada ,  Kazue Murata

    IPC分类号： C05B1900

    CPC分类号： B01J2/16 ,  B01J2/18 ,  F26B3/0926

    摘要： A production method and system for granulating powdered material wherein powdered material is fluidized by applying heated pulsating vibration air, and the fluidized powdered material is suspended up and down at a regular cycle by means of heated pulsating vibration air, the aggregated material is compressed by further vibration of pulsating vibration air, whereby the aggregated powdered material is efficiently made into granulated material with high density and rather small specific volume without causing projection on the surface and without being made porous. The production system is comprised of a granulation tank for storing powdered material to be granulated, the granulation tank having a supply port for introducing heated air at the bottom thereof, a discharge port for discharging the introduced heated air at the top thereof, and a fluidization bed provided above the supply port for receiving the powdered material. A spray apparatus for spraying a binder solution provided in the granulation tank for aggregating the powdered material stored in the granulation tank for growing the material is provided. An air source connected to the supply port of the granulation tank via a conduit pipe; heating apparatus interposed in the conduit pipe for heating the air generated from the air source; and a pulsating vibration air generation means interposed in the conduit pipe for converting the air generated from the air source to pulsating vibration air.

    摘要翻译： 通过施加加热的脉动振动空气使粉末材料流化的制粉方法和制造方法，流化粉末材料通过加热的脉动振动空气以规律的周期上下悬浮，聚集的材料进一步压缩 脉动振动空气的振动，由此将聚集的粉末材料有效地制成具有高密度和相当小的比体积的粒状材料，而不会在表面上产生突起而不被制成多孔。 该生产系统包括用于储存待造粒的粉末材料的造粒罐，该造粒罐具有用于在其底部引入加热空气的供给口，用于在其顶部排出引入的加热空气的排出口， 提供在供应口上方的用于接收粉末材料的床。 提供一种喷雾装置，用于喷射设置在造粒罐中的粘合剂溶液，用于聚集存储在造粒罐中用于生长材料的粉末材料。 通过管道连接到造粒罐的供应口的空气源; 插入导管中的加热装置，用于加热从空气源产生的空气; 以及插入在导管中的脉动振动空气产生装置，用于将从空气源产生的空气转换成脉动的振动空气。

    Powder density-measuring device and automatic powder spray amount control system using the same
    8.
    发明申请
    Powder density-measuring device and automatic powder spray amount control system using the same 审中-公开
    粉末密度测量装置和自动粉末喷雾量控制系统使用相同

    公开(公告)号：US20050173555A1

    公开(公告)日：2005-08-11

    申请号：US10515996

    申请日：2003-05-30

    申请人： Eiichiro Hirota ,  Kimiaki Hayakawa ,  Yuji Iwase ,  Hirokazu Yoshimoto ,  Kiyoshi Morimoto

    发明人： Eiichiro Hirota ,  Kimiaki Hayakawa ,  Yuji Iwase ,  Hirokazu Yoshimoto ,  Kiyoshi Morimoto

    IPC分类号： B05B7/14 ,  B05B12/08 ,  G01N21/59 ,  B67D5/08 ,  B67D5/38

    CPC分类号： B05B7/1404 ,  B05B7/1445 ,  B05B12/08 ,  G01N21/59

    摘要： A powder concentration measuring apparatus comprising a pair of purge gas introducing paths being provided across a material measuring path which introduces a powder material pneumatically transported, a pair of transparent windows being provided so that said material measuring path is viewable through said pair of purge gas introducing paths at the one of the transparent windows, and the light receiving device being provided at the other of the transparent windows, and a powder concentration operation and control means, wherein the control means calculates a powder concentration depending on the light amount received by the light receiving device when a light beam is projected into the material measuring path from the light projecting device.

    摘要翻译： 一种粉末浓度测量装置，包括一对吹扫气体导入路径，横跨材料测量路径设置，所述材料测量路径引入气动输送的粉末材料，设置一对透明窗口，使得所述材料测量路径可通过所述一对吹扫气体引入 在透明窗口中的一个处的路径和设置在另一个透明窗口处的光接收装置以及粉末浓度操作和控制装置，其中控制装置根据由光接收的光量计算粉末浓度 当光束从投光装置投射到材料测量路径中时，接收装置。

    Pulsating vibration air generation apparatus
    9.
    发明申请
    Pulsating vibration air generation apparatus 有权
    脉动振动空气发生装置

    公开(公告)号：US20050076776A1

    公开(公告)日：2005-04-14

    申请号：US10492535

    申请日：2002-10-25

    申请人： Kiyoshi Morimoto ,  Hirokazu Yoshimoto ,  Yasushi Watanabe

    发明人： Kiyoshi Morimoto ,  Hirokazu Yoshimoto ,  Yasushi Watanabe

    IPC分类号： B65G53/66 ,  B06B1/20 ,  F15B21/12 ,  F01B1/00

    CPC分类号： B06B1/20 ,  F15B21/125 ,  Y10T137/86405 ,  Y10T137/86421

    摘要： A pulsating vibration air generation apparatus capable of sharply and quickly controlling air flow in turning on and off operation, thereby generating a pulsating vibration air with sharp and hardly attenuated peak and valley, and capable of operation without occurrence of so much mechanical vibration. The pulsating vibration air generation apparatus is comprised of a main body having a tubular hollow space R2 with which two air communication ports are associated, and a rotary body situated for rotation in the tubular hollow space R2 and which has a peripheral side surface S4c so as to slide on the inner surface S2c forming the tubular hollow space R2.

    摘要翻译： 一种脉动振动空气产生装置，其能够在打开和关闭操作中快速和快速地控制空气流动，从而产生具有锐利且几乎不衰减的峰谷的脉动振动空气，并且能够在没有发生太多机械振动的情况下进行操作。 脉动振动空气产生装置包括：主体，其具有与空气连通口相连的管状中空空间R2;以及旋转体，其位于管状中空空间R2中并且具有外周侧面S4c， 在形成管状中空空间R2的内表面S2c上滑动。

    INTRABUCCALLY RAPIDLY DISINTEGRATING TABLET AND A PRODUCTION METHOD OF THE TABLETS
    10.
    发明申请
    INTRABUCCALLY RAPIDLY DISINTEGRATING TABLET AND A PRODUCTION METHOD OF THE TABLETS 有权
    快速消毒片和片剂的生产方法

    公开(公告)号：US20120135076A1

    公开(公告)日：2012-05-31

    申请号：US13282271

    申请日：2011-10-26

    申请人： Motohiro OHTA ,  Eiji Hayakawa ,  Kunio Ito ,  Sanji Tokuno ,  Kiyoshi Morimoto ,  Yasushi Watanabe

    发明人： Motohiro OHTA ,  Eiji Hayakawa ,  Kunio Ito ,  Sanji Tokuno ,  Kiyoshi Morimoto ,  Yasushi Watanabe

    IPC分类号： A61K9/20 ,  B02C23/00

    CPC分类号： A61K9/2095 ,  A61J3/10 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2027

    摘要： An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.

    摘要翻译： 通过简单的方法制造的口腔内快速崩解片剂具有足够的实用硬度并且在口腔中快速崩解及其制备方法。 通过将粉末材料生长成具有固定粒径的造粒材料，粉末材料包括作为主要成分的糖醇或糖类的粉末材料，其平均粒径不大于 通过将由此获得的造粒材料与活性成分和崩解剂混合，并将混合物压缩成预定形状。