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Patent Agency Ranking
公开(公告)号：US10328213B2
公开(公告)日：2019-06-25
申请号：US14211702
申请日：2014-03-14
Applicant: Muffin Incorporated
Inventor： Richard B. Sisken , Ryan Pruchnic , Frank J. Fischer, Jr. , Steven Charlebois
Abstract: Methods and apparatus are provided for treating tissue with apparatus that includes an priming portion for initiating a healing response in the tissue to be treated, and which delivers a bioactive agent during or after preparing tissue adjacent the apparatus, as by generating or aiding a healing, regeneration or repair response in the tissue. The priming portion may comprise an abrasive surface, fluid ejection ports, and/or stimulation by electrical, thermal, or light energy.
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公开(公告)号：US09388451B2
公开(公告)日：2016-07-12
申请号：US14038080
申请日：2013-09-26
Applicant: Cook Biotech Incorporated , Muffin Incorporated
Inventor： Niraj Ramachandran , Frank J. Fischer, Jr. , Michael C. Hiles , Neal E. Fearnot
IPC: C12Q1/42 , G01N33/50 , G01N33/566 , A61M25/00
CPC classification number: C12Q1/42 , G01N33/5005 , G01N33/5014 , G01N33/502 , G01N33/566
Abstract: Described are methods and systems for testing lumens of cannulated delivery components or assemblies thereof that may be used to deliver cells to a patient. Test cells are contacted with walls of the lumens and/or liquids that contact walls of the lumens, potentially over an incubation period. The test cells are then assessed for an effect of the wall contact, or the liquid contact, on at least one and preferably multiple characteristics of the test cells such as innate immune response, metabolic activity, viability, cytotoxic response, and/or motility. Methods and systems as described can be used in the development and/or manufacture of cannulated delivery devices, for example providing specifications for design or process inputs or outputs, design or process validations, and/or device lot approvals. Also described are devices or products produced in accordance with such methods and systems.
Abstract translation: 描述了用于测试可用于将细胞递送至患者的插管输送组件或其组件的腔的方法和系统。 可能在潜伏期内，将测试细胞与腔内壁和/或液体壁接触。 然后评估测试细胞对测试细胞的至少一个优选多个特征（例如先天免疫应答，代谢活性，存活力，细胞毒性反应和/或运动）的壁接触或液体接触的影响。 所描述的方法和系统可以用于开发和/或制造插管式输送装置，例如提供设计或过程输入或输出的规范，设计或过程验证和/或装置批次批准。 还描述了根据这些方法和系统生产的设备或产品。
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公开(公告)号：US09604037B2
公开(公告)日：2017-03-28
申请号：US13910693
申请日：2013-06-05
Applicant: Cook Medical Technologies LLC , Muffin Incorporated
Inventor： Frank J. Fischer, Jr. , James R. Randolph , Neal E. Fearnot , Jimmy L. Taylor, Jr. , Gary Bradford Shirley
CPC classification number: A61M25/1011 , A61B34/20 , A61M25/0026 , A61M25/0041 , A61M25/0068 , A61M25/007 , A61M25/10 , A61M37/0092 , A61M2025/0003 , A61M2025/0004 , A61M2025/0042 , A61M2025/1015 , A61M2025/1052 , A61M2025/1061 , A61M2025/1093
Abstract: Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients.
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公开(公告)号：US09855401B2
公开(公告)日：2018-01-02
申请号：US15159025
申请日：2016-05-19
Applicant: Muffin Incorporated
Inventor： Frank J. Fischer, Jr.
CPC classification number: A61M25/007 , A61M5/158 , A61M5/3286 , A61M5/329 , A61M5/3291 , A61M5/3295 , A61M5/3298 , A61M2202/0064 , A61M2202/097
Abstract: Arrangements and methods for delivering bioactive agents and/or cells into an extended volume of tissue are disclosed. In one embodiment, a cell-delivering needle arrangement has a tube positioned within a tube and fixedly attached to a wall thereof. In one exemplary method, a cell-delivering needle is advanced into tissue, a suspension of cells is passed through a first lumen and out of side ports, and a suspension of cells is passed through a second lumen and out of a distal opening. Other embodiments are disclosed.
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公开(公告)号：US10532193B2
公开(公告)日：2020-01-14
申请号：US15453194
申请日：2017-03-08
Applicant: Muffin Incorporated
Inventor： Frank J. Fischer, Jr. , James R. Randolph , Neal E. Fearnot , Jimmy L. Taylor, Jr. , Gary B. Shirley
Abstract: Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients.
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