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公开(公告)号：US20220280696A1
公开(公告)日：2022-09-08
申请号：US17527679
申请日：2021-11-16
摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
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公开(公告)号：US09931439B2
公开(公告)日：2018-04-03
申请号：US14088606
申请日：2013-11-25
发明人： Neal E. Fearnot , Michael C. Hiles , Jeremy Metz , F. Joseph Obermiller , Andrew J. Kaucher , Steven Charlebois
CPC分类号： A61L27/60 , A61F2/0063 , A61F2/02 , A61F2002/0072 , A61F2210/0076 , A61F2250/0003 , A61F2250/0068 , A61L27/3633 , A61L27/38
摘要： Described are medical graft materials and devices which can be usefully modified with liquid additives such as cell suspensions, bioactive agents, or combinations of these. The medical graft materials and devices can have a first outer surface and a second outer surface and can define an internal chamber between the first outer surface and the second outer surface. The medical graft materials and devices can also have at least one region of the graft material interrupting the chamber and surrounded by the chamber. Also described are methods for making and using these medical graft materials and devices.
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公开(公告)号：US20160082157A1
公开(公告)日：2016-03-24
申请号：US14835005
申请日：2015-08-25
CPC分类号： A61L27/50 , A61L27/24 , A61L27/3604 , A61L27/3633 , A61L27/3808 , A61L27/3826 , A61L2430/02 , A61L2430/06 , A61L2430/26 , A61L2430/28 , A61L2430/30 , A61L2430/32 , A61L2430/34 , C12M21/08 , C12M23/06 , C12M23/34 , C12M25/14 , C12N5/0062 , C12N2533/54
摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
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公开(公告)号：US20190117843A1
公开(公告)日：2019-04-25
申请号：US16127872
申请日：2018-09-11
摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
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公开(公告)号：US11077231B2
公开(公告)日：2021-08-03
申请号：US14834971
申请日：2015-08-25
摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
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公开(公告)号：US09388451B2
公开(公告)日：2016-07-12
申请号：US14038080
申请日：2013-09-26
IPC分类号： C12Q1/42 , G01N33/50 , G01N33/566 , A61M25/00
CPC分类号： C12Q1/42 , G01N33/5005 , G01N33/5014 , G01N33/502 , G01N33/566
摘要： Described are methods and systems for testing lumens of cannulated delivery components or assemblies thereof that may be used to deliver cells to a patient. Test cells are contacted with walls of the lumens and/or liquids that contact walls of the lumens, potentially over an incubation period. The test cells are then assessed for an effect of the wall contact, or the liquid contact, on at least one and preferably multiple characteristics of the test cells such as innate immune response, metabolic activity, viability, cytotoxic response, and/or motility. Methods and systems as described can be used in the development and/or manufacture of cannulated delivery devices, for example providing specifications for design or process inputs or outputs, design or process validations, and/or device lot approvals. Also described are devices or products produced in accordance with such methods and systems.
摘要翻译： 描述了用于测试可用于将细胞递送至患者的插管输送组件或其组件的腔的方法和系统。 可能在潜伏期内，将测试细胞与腔内壁和/或液体壁接触。 然后评估测试细胞对测试细胞的至少一个优选多个特征（例如先天免疫应答，代谢活性，存活力，细胞毒性反应和/或运动）的壁接触或液体接触的影响。 所描述的方法和系统可以用于开发和/或制造插管式输送装置，例如提供设计或过程输入或输出的规范，设计或过程验证和/或装置批次批准。 还描述了根据这些方法和系统生产的设备或产品。
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7.发明申请公开(公告)号：US20150359940A1
公开(公告)日：2015-12-17
申请号：US14834971
申请日：2015-08-25
CPC分类号： A61L27/50 , A61L27/24 , A61L27/3604 , A61L27/3633 , A61L27/3808 , A61L27/3826 , A61L2430/02 , A61L2430/06 , A61L2430/26 , A61L2430/28 , A61L2430/30 , A61L2430/32 , A61L2430/34 , C12M21/08 , C12M23/06 , C12M23/34 , C12M25/14 , C12N5/0062 , C12N2533/54
摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
摘要翻译： 描述了可用于制备用于给予患者的含细胞的移植材料的方法，细胞生长底物和装置。 可以在细胞生长底物中定义管状通道以促进细胞分布到底物中。 还描述了用于制备细胞接种组合物的方法和装置，在施用细胞之前预处理细胞生长底物的方法和装置，以及具有新基底的细胞接种移植物及其用途。
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公开(公告)号：US11173231B2
公开(公告)日：2021-11-16
申请号：US16127872
申请日：2018-09-11
摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
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公开(公告)号：US10071187B2
公开(公告)日：2018-09-11
申请号：US14835005
申请日：2015-08-25
CPC分类号： A61L27/50 , A61L27/24 , A61L27/3604 , A61L27/3633 , A61L27/3808 , A61L27/3826 , A61L2430/02 , A61L2430/06 , A61L2430/26 , A61L2430/28 , A61L2430/30 , A61L2430/32 , A61L2430/34 , C12M21/08 , C12M23/06 , C12M23/34 , C12M25/14 , C12N5/0062 , C12N2533/54
摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
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公开(公告)号：US20140188250A1
公开(公告)日：2014-07-03
申请号：US14088606
申请日：2013-11-25
发明人： Neal E. Fearnot , Michael C. Hiles , Jeremy Metz , F. Joseph Obermiller , Andrew J. Kaucher , Steven Charlebois
IPC分类号： A61F2/01
CPC分类号： A61L27/60 , A61F2/0063 , A61F2/02 , A61F2002/0072 , A61F2210/0076 , A61F2250/0003 , A61F2250/0068 , A61L27/3633 , A61L27/38
摘要： Described are medical graft materials and devices which can be usefully modified with liquid additives such as cell suspensions, bioactive agents, or combinations of these. Also described are methods for making and using these medical graft materials and devices.
摘要翻译： 描述了可以用液体添加剂如细胞悬浮液，生物活性剂或它们的组合有效地改性的医用移植材料和装置。 还描述了制造和使用这些医用移植材料和装置的方法。
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