公开(公告)号：US07069252B2

公开(公告)日：2006-06-27

申请号：US10337419

申请日：2003-01-07

申请人： Munehiko Ishimi ,  Hirofumi Fujiwara ,  Kazuhiko Sekine ,  Toshihiko Kaji ,  Toshiyuki Iida ,  Yoshihide Tanaka ,  Keiko Shiraishi ,  Akimitsu Yomoda ,  Seinosuke Kashima

发明人： Munehiko Ishimi ,  Hirofumi Fujiwara ,  Kazuhiko Sekine ,  Toshihiko Kaji ,  Toshiyuki Iida ,  Yoshihide Tanaka ,  Keiko Shiraishi ,  Akimitsu Yomoda ,  Seinosuke Kashima

IPC分类号： G06F17/60

CPC分类号： G06Q30/06 ,  G06Q10/087 ,  G06Q10/0875 ,  G06Q20/10 ,  G06Q20/3821 ,  G06Q40/00

摘要： A user registration processor unit registers the user registration information to the database, which includes the public key certification acquired from the certification authority that has jurisdiction over each party by the request from the transaction party including seller, buyer, and transportation company. A transfer registration processor unit changes the access right holder and the cargo owner of the shipment information registered to the database at the start of transaction in compliance with the request for request for changing registration of the party with the digital signature and public key certification attached. A verification processor unit achieves the transfer registration with legal binding power by verifying that the digital signature attached to the request for request for changing registration has been prepared by the private key which makes a pair with the public key certificate registered to the database and receiving the approval of the other party.

公开(公告)号：US20090016987A1

公开(公告)日：2009-01-15

申请号：US11596674

申请日：2005-05-17

申请人： Naoki Aikawa ,  Seitaro Fujishima ,  Kazuhiko Sekine

发明人： Naoki Aikawa ,  Seitaro Fujishima ,  Kazuhiko Sekine

IPC分类号： C07K14/54 ,  A61K38/21 ,  A61P29/00

CPC分类号： G01B11/04 ,  G01N21/8806 ,  G01N21/8986

摘要： The object of the present invention is, based on the finding of a novel effect of IL-18, to provide pharmaceutical compositions containing IL-18 and therapeutic methods, for preventing, improving, or treating inflammatory diseases such as systemic inflammatory response syndrome (SIRS). Inflammatory diseases, such as SIRS, can be prevented, improved, or treated by administering the pharmaceutical compositions according to the present invention containing IL-18 in an amount which does not bring the decreased interleukin 18 level in either plasma or liver to a higher level than normal.

摘要翻译： 本发明的目的是基于IL-18的新作用的发现，提供含有IL-18的药物组合物和治疗方法，用于预防，改善或治疗诸如全身炎症反应综合征（SIRS） ）。 可以通过给予含有IL-18的本发明的药物组合物来防止，改善或治疗炎性疾病，其量不会使血浆或肝脏中的白介素18水平降低到更高的水平 比正常