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    Hydrogel-forming sustained-release preparation
    3.
    发明授权
    Hydrogel-forming sustained-release preparation 失效
    水凝胶形成持续释放制剂

    公开(公告)号：US06699503B1

    公开(公告)日：2004-03-02

    申请号：US09702880

    申请日：2000-11-01

    申请人： Kazuhiro Sako ,  Hiroshi Nakashima ,  Toyohiro Sawada ,  Akira Okada ,  Muneo Fukui

    发明人： Kazuhiro Sako ,  Hiroshi Nakashima ,  Toyohiro Sawada ,  Akira Okada ,  Muneo Fukui

    IPC分类号： A61K910

    CPC分类号： A61K9/2054 ,  A61K9/2018 ,  A61K9/2031

    摘要： The invention provides a hydrogen-type sustained-release preparation comprising (1) at least one drug, (2) an additive which insures a penetration of water into the core of the preparation and (3) a hydrogen-forming polymer, wherein said preparation is capable of undergoing substantially complete gelation during its stay in the upper digestive tract such as stomach and small intestine and is capable of releasing the drug in the lower digestive tract including colon. By the preparation of the invention, the drug is efficiently released and absorbed even in the colon so that a steady and sustained release effect can be achieved.

    摘要翻译： 本发明提供一种氢型缓释制剂，其包含（1）至少一种药物，（2）确保水渗入制剂核心的添加剂和（3）形成氢的聚合物，其中所述制剂 能够在其停留在上消化道如胃和小肠期间经历基本上完全的凝胶化，并且能够在包括结肠的下消化道中释放药物。 通过本发明的制备，即使在结肠中也能有效地释放和吸收药物，从而可以获得稳定且持续的释放效果。

    Colon-specific drug release system
    5.
    发明授权
    Colon-specific drug release system 有权

    公开(公告)号：US06506407B2

    公开(公告)日：2003-01-14

    申请号：US09952992

    申请日：2001-09-14

    申请人： Shunsuke Watanabe ,  Hitoshi Kawai ,  Masataka Katsuma ,  Muneo Fukui

    发明人： Shunsuke Watanabe ,  Hitoshi Kawai ,  Masataka Katsuma ,  Muneo Fukui

    IPC分类号： A61K948

    CPC分类号： A61K9/2886 ,  A61K9/2018 ,  A61K9/2826 ,  A61K9/2846 ,  A61K9/4808

    摘要： A system for releasing a drug specifically in the colon of the gastrointestinal tract, which comprises a drug (b) coated with an organic acid-soluble polymer material (a), and a saccharide (c) which rapidly generates an organic acid by the action of enterobacteria in the lower part of the gastrointestinal tract; a colon-specific drug release oral preparation, which comprises a composition comprising a drug (b) coated with an organic acid-soluble polymer material (a) and a saccharide (c) which rapidly generates an organic acid by the action of enterobacteria in the lower part of the gastrointestinal tract, said composition being coated with an enteric coating polymer material (d). The invention provides a drug release system and a preparation which utilize enterobacteria, which do not form harmful substances due to the release-starting mechanism, show rapid degradation, and have higher colon specificity.

    Hydrogel-forming sustained-release preparation
    6.
    发明授权
    Hydrogel-forming sustained-release preparation 失效
    水凝胶形成持续释放制剂

    公开(公告)号：US06436441B1

    公开(公告)日：2002-08-20

    申请号：US08403752

    申请日：1995-03-20

    申请人： Kazuhiro Sako ,  Hiroshi Nakashima ,  Toyohiro Sawada ,  Akira Okada ,  Muneo Fukui

    发明人： Kazuhiro Sako ,  Hiroshi Nakashima ,  Toyohiro Sawada ,  Akira Okada ,  Muneo Fukui

    IPC分类号： A61K922

    CPC分类号： A61K9/2054 ,  A61K9/2018 ,  A61K9/2031

    摘要： The invention provides a hydrogel-type sustained-release preparation comprising (1) at least one drug, (2) an additive which insures a penetration of water into the core of the preparation and (3) a hydrogel-forming polymer, wherein said preparation is capable of undergoing substantially complete gelation during its stay in the upper digestive tract such as stomach and small intestine and is capable of releasing the drug in the lower digestive tract including colon. By the preparation of the invention, the drug is efficiently released and absorbed even in the colon so that a steady and sustained release effect can be achieved.

    摘要翻译： 本发明提供一种水凝胶型持续释放制剂，其包含（1）至少一种药物，（2）确保水渗入制剂核心的添加剂，和（3）水凝胶形成聚合物，其中所述制剂 能够在上消化道（如胃和小肠）停留期间发生基本上完全的凝胶化，并且能够在包括结肠的下消化道中释放药物。通过本发明的制备，药物被有效地释放和吸收 即使在结肠中也能达到稳定和持续释放的效果。

    Colon-specific drug release system
    7.
    发明授权
    Colon-specific drug release system 有权
    结肠特异性药物释放系统

    公开(公告)号：US06368629B1

    公开(公告)日：2002-04-09

    申请号：US09183339

    申请日：1998-10-30

    申请人： Shunsuke Watanabe ,  Hitoshi Kawai ,  Masataka Katsuma ,  Muneo Fukui

    发明人： Shunsuke Watanabe ,  Hitoshi Kawai ,  Masataka Katsuma ,  Muneo Fukui

    IPC分类号： A61K932

    CPC分类号： A61K9/2886 ,  A61K9/2018 ,  A61K9/2826 ,  A61K9/2846 ,  A61K9/4808

    摘要： A system for releasing a drug specifically in the colon of the gastrointestinal tract, which comprises a drug (b) coated with an organic acid-soluble polymer material (a), and a saccharide (c) which rapidly generates an organic acid by the action of enterobacteria in the lower part of the gastrointestinal tract; a colon-specific drug release oral preparation, which comprises a composition comprising a drug (b) coated with an organic acid-soluble polymer material (a) and a saccharide (c) which rapidly generates an organic acid by the action of enterobacteria in the lower part of the gastrointestinal tract, said composition being coated with an enteric coating polymer material (d). The invention provides a drug release system and a preparation which utilize enterobacteria, which do not form harmful substances due to the release-starting mechanism, show rapid degradation, and have higher colon specificity.

    摘要翻译： 一种用于特别在胃肠道结肠中释放药物的系统，其包括用有机酸溶性聚合物材料（a）涂覆的药物（b）和通过动作快速产生有机酸的糖（c） 的胃肠道下部的肠细菌; 一种结肠特异性药物释放口服制剂，其包含包含有机酸溶性聚合物材料（a）的药物（b）和通过肠杆菌的作用快速产生有机酸的糖（c）的组合物 所述组合物涂覆有肠溶衣聚合物材料（d）。本发明提供一种药物释放系统和利用肠杆菌的制剂，其不会由于释放启动机制而形成有害物质 快速降解，并具有更高的结肠特异性。

    Drug release controlling coating material for long acting formulations
    9.
    发明授权
    Drug release controlling coating material for long acting formulations 失效
    用于长效制剂的药物释放控制涂料

    公开(公告)号：US5258186A

    公开(公告)日：1993-11-02

    申请号：US885910

    申请日：1992-05-18

    申请人： Tadayoshi Ohmura ,  Muneo Fukui ,  Hiroshi Sugiura ,  Satoru Yoneya ,  Toshiharu Hosono ,  Atsushi Kajiyama

    发明人： Tadayoshi Ohmura ,  Muneo Fukui ,  Hiroshi Sugiura ,  Satoru Yoneya ,  Toshiharu Hosono ,  Atsushi Kajiyama

    IPC分类号： A61K9/50 ,  A61K9/16

    CPC分类号： A61K9/5026 ,  A61K9/5078

    摘要： A coating material for controlling drug release, useful for long acting formulations--e.g. for once-a-day administration, and to a long acting granular composition comprising a drug (especially one conventionally difficult to prepare in long acting form) coated with the coating material. This composition may be mixed with other granular drug formulations. The drug-release controlling coating material comprising, in a specific ratio, one specific water-insoluble and low water-permeability polymers and two materials differing from each other in the pH-dependency of their solubility (pH-dependent polymer-materials).

    摘要翻译： 用于控制药物释放的涂料，可用于长效制剂 - 例如， 以及长效粒状组合物，其包含涂覆有涂层材料的药物（特别是通常难以制备的长效型）。 该组合物可与其它颗粒药物制剂混合。 所述药物释放控制涂层材料以其特定比例包含一种特定的水不溶性和低透水性聚合物，以及两者在溶解度（pH依赖性聚合物材料）的pH依赖性方面彼此不同。