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公开(公告)号：US10414751B2
公开(公告)日：2019-09-17
申请号：US16270717
申请日：2019-02-08
IPC分类号： C07D401/06 , A61P31/10 , C07B63/04
摘要： The present invention relates to polymorphic forms of compound 1 or 1a and processes for preparing compound 1 and 1a polymorphs, which are useful as antifungal agents. In particular, the invention seeks to provide a new methodology for preparing polymorphs of compound 1 and substituted derivatives thereof.
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公开(公告)号：US10399943B2
公开(公告)日：2019-09-03
申请号：US15126392
申请日：2015-03-19
申请人： Mycovia Pharmaceuticals, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： William J. Hoekstra , Christopher M. Yates , Mark Behnke , Asaf Alimardanov , Scott A. David , Douglas Franklin Fry
IPC分类号： C07D213/26 , C07D401/06 , C07D213/50 , C07D405/06 , C07D213/30 , C07D213/38
摘要： The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
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公开(公告)号：US10370353B2
公开(公告)日：2019-08-06
申请号：US15835991
申请日：2017-12-08
IPC分类号： C07D401/06
摘要： The present invention relates to polymorphic forms of compound 1 or 1a and processes for preparing compound 1 and 1a polymorphs, which are useful as antifungal agents. In particular, the invention seeks to provide a new methodology for preparing polymorphs of compound 1 and substituted derivatives thereof.
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公开(公告)号：US20190177298A1
公开(公告)日：2019-06-13
申请号：US16132973
申请日：2018-09-17
申请人： Mycovia Pharmaceuticals, Inc , The U.S.A., as represented by the Secretary, Department of Health and Human Services
发明人： William J. Hoekstra , Christopher M. Yates , Mark Behnke , Asaf Alimardanov , Scott A. David , Douglas Franklin Fry
IPC分类号： C07D401/06 , C07D213/56 , C07D405/06 , C07D213/38 , C07D213/50
摘要： The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
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公开(公告)号：US11247981B2
公开(公告)日：2022-02-15
申请号：US16735094
申请日：2020-01-06
IPC分类号： C07D401/06 , A61K45/06 , C07F9/6524 , C12N9/02
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US11051514B2
公开(公告)日：2021-07-06
申请号：US15574775
申请日：2016-05-17
发明人： William J. Hoekstra , Christopher M. Yates , Robert J. Schotzinger , Michael R. Loso , Gary D. Gustafson , Michael T. Sullenberger , Kimberly Steward , Javier Delgado , Xuelin Wang
IPC分类号： A01N43/653 , C07D401/06
摘要： The present invention relates to compounds of Formula (I): wherein R1 is as defined herein, or an acceptable salt, solvate, prodrug or hydrate thereof. The compounds of Formula I are inhibitors of metalloenzymes, such as lanosterol demethylase (CYP51).
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公开(公告)号：US10421741B2
公开(公告)日：2019-09-24
申请号：US16030228
申请日：2018-07-09
申请人： Mycovia Pharmaceuticals, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： William J. Hoekstra , Christopher M. Yates , Mark Behnke , Asaf Alimardanov , Scott A. David , Douglas Franklin Fry
IPC分类号： C07D401/06 , C07D405/06 , C07D213/30 , C07D213/38 , C07D213/56 , C07D213/50
摘要： The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
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公开(公告)号：US20190210994A1
公开(公告)日：2019-07-11
申请号：US16270717
申请日：2019-02-08
IPC分类号： C07D401/06 , C07B63/04 , A61P31/10
CPC分类号： C07D401/06 , A61P31/10 , C07B63/04 , C07B2200/13
摘要： The present invention relates to polymorphic forms of compound 1 or 1a and processes for preparing compound 1 and 1a polymorphs, which are useful as antifungal agents. In particular, the invention seeks to provide a new methodology for preparing polymorphs of compound 1 and substituted derivatives thereof.
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公开(公告)号：US20180319768A1
公开(公告)日：2018-11-08
申请号：US15835991
申请日：2017-12-08
IPC分类号： C07D401/06
CPC分类号： C07D401/06 , A61P31/10 , C07B63/04 , C07B2200/13
摘要： The present invention relates to polymorphic forms of compound 1 or 1a and processes for preparing compound 1 and 1a polymorphs, which are useful as antifungal agents. In particular, the invention seeks to provide a new methodology for preparing polymorphs of compound 1 and substituted derivatives thereof.
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公开(公告)号：US20210360921A1
公开(公告)日：2021-11-25
申请号：US17338578
申请日：2021-06-03
发明人： William J. Hoekstra , Christopher M. Yates , Robert J. Schotzinger , Michael R. Loso , Gary D. Gustafson , Michael T. Sullenberger , Kimberly Steward , Javier Delgado , Xuelin Wang
IPC分类号： A01N43/653 , C07D401/06
摘要： The present invention relates to compounds of Formula (I): wherein R1 is as defined herein, or an acceptable salt, solvate, prodrug or hydrate thereof. The compounds of Formula I are inhibitors of metalloenzymes, such as lanosterol demethylase (CYP51).
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