公开(公告)号：US10370329B2

公开(公告)日：2019-08-06

申请号：US15573290

申请日：2016-04-22

申请人： Mylan Laboratories Limited

发明人： Ramesh Dandala ,  Sureshbabu Jayachandra ,  Vipin Kumar Kaushik ,  Nageshwara Rao Achanta ,  Sivaprasad Dorasala

IPC分类号： C07C315/06 ,  C07D209/48 ,  C07C311/19 ,  C07C317/28 ,  C07C69/76 ,  C07C315/04

摘要： A process for the resolution of racemic 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine using novel chiral salts is disclosed. An L-phenylalanine p-toluene-sulfonamide salt of (S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine and a di-p-toluoyl-L-tartaric acid salt of (S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine are also provided.

公开(公告)号：US20180312484A1

公开(公告)日：2018-11-01

申请号：US15772833

申请日：2016-11-03

申请人： Mylan Laboratories Limited

发明人： Sureshbabu Jayachandra ,  Vipin Kumar Kaushik ,  Vijaya Krishna RAVI ,  Vikas Chandra Dev ,  Saiprasad Kottolla ,  Potla Venkata Srinivasa Rao ,  Srinivas Vakiti ,  Chaitanya Muggu ,  Subramanyam Dandala

IPC分类号： C07D307/33 ,  C07D319/12

CPC分类号： C07D307/33 ,  C07D307/20 ,  C07D319/12

摘要： A process for the preparation of intermediates 9, useful in the synthesis of sofosbuvir, as well as intermediates of formula [12] are disclosed herein.

公开(公告)号：US10344009B2

公开(公告)日：2019-07-09

申请号：US15772833

申请日：2016-11-03

申请人： Mylan Laboratories Limited

发明人： Sureshbabu Jayachandra ,  Vipin Kumar Kaushik ,  Vijaya Krishna Ravi ,  Vikas Chandra Dev ,  Saiprasad Kottolla ,  Potla Venkata Srinivasa Rao ,  Srinivas Vakiti ,  Chaitanya Muggu ,  Subramanyam Dandala

IPC分类号： C07D307/33 ,  C07D319/12 ,  C07D307/20

摘要： A process for the preparation of intermediates 9, useful in the synthesis of sofosbuvir, as well as intermediates of formula [12] are disclosed herein.

公开(公告)号：US20180134660A1

公开(公告)日：2018-05-17

申请号：US15573290

申请日：2016-04-22

申请人： Mylan Laboratories Limited

发明人： Ramesh Dandala ,  Sureshbabu Jayachandra ,  Vipin Kumar Kaushik ,  Nageshwara Rao Achanta ,  Sivaprasad Dorasala

IPC分类号： C07D209/48 ,  C07C315/04

CPC分类号： C07D209/48 ,  C07B2200/07 ,  C07C69/76 ,  C07C311/19 ,  C07C315/04 ,  C07C315/06 ,  C07C317/28

摘要： A process for the resolution of racemic 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine using novel chiral salts is disclosed. An L-phenylalanine p-toluene-sulfonamide salt of (S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine and a di-p-toluoyl-L-tartaric acid salt of (S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine are also provided.