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公开(公告)号：US09206438B2
公开(公告)日：2015-12-08
申请号：US13462636
申请日：2012-05-02
IPC分类号： C12N15/82 , C07K14/435
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C07K14/43563 , C12N15/8218 , C12N15/8286 , C12N2310/14 , Y02A40/162
摘要： The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants, using interfering ribonucleic acid (RNA) molecules. Compositions and combinations containing the interfering RNA molecules of the invention for use in topical applications, for example in the form of insecticides.
摘要翻译： 本发明涉及使用干扰核糖核酸（RNA）分子的昆虫害虫侵染的遗传控制，特别是预防和/或控制植物害虫侵染。 含有用于局部应用的本发明的干扰RNA分子的组合物和组合，例如以杀虫剂的形式。
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公开(公告)号：US20120322660A1
公开(公告)日：2012-12-20
申请号：US13462636
申请日：2012-05-02
IPC分类号： A01N57/16 , C12N15/11 , C12N15/63 , A01P13/00 , A01P7/04 , A01N63/00 , A01N37/46 , C07H21/02 , C12N1/21
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C07K14/43563 , C12N15/8218 , C12N15/8286 , C12N2310/14 , Y02A40/162
摘要： The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants, using interfering ribonucleic acid (RNA) molecules. Compositions and combinations containing the interfering RNA molecules of the invention for use in topical applications, for example in the form of insecticides.
摘要翻译： 本发明涉及使用干扰核糖核酸（RNA）分子的昆虫害虫侵染的遗传控制，特别是预防和/或控制植物害虫侵染。 含有用于局部应用的本发明的干扰RNA分子的组合物和组合，例如以杀虫剂的形式。
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公开(公告)号：US09845479B2
公开(公告)日：2017-12-19
申请号：US13462610
申请日：2012-05-02
IPC分类号： C12N15/82 , C12N15/113 , C07K14/435
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C07K14/43563 , C12N15/8218 , C12N15/8286 , C12N2310/14 , Y02A40/162
摘要： The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants, using interfering ribonucleic acid (RNA) molecules. The invention provides transgenic plants that (i) express or are capable of expressing interfering RNAs of the invention and (ii) are resistant to infestation by insect pest species.
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公开(公告)号：US20130231246A9
公开(公告)日：2013-09-05
申请号：US13462636
申请日：2012-05-02
IPC分类号： A01N57/16 , C12N15/11 , C12N15/63 , A01P13/00 , A01P7/04 , A01N63/00 , A01N37/46 , C07H21/02 , C12N1/21
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C07K14/43563 , C12N15/8218 , C12N15/8286 , C12N2310/14 , Y02A40/162
摘要： The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants, using interfering ribonucleic acid (RNA) molecules. Compositions and combinations containing the interfering RNA molecules of the invention for use in topical applications, for example in the form of insecticides.
摘要翻译： 本发明涉及使用干扰核糖核酸（RNA）分子的昆虫害虫侵染的遗传控制，特别是预防和/或控制植物害虫侵染。 含有用于局部应用的本发明的干扰RNA分子的组合物和组合，例如以杀虫剂的形式。
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公开(公告)号：US20120297501A1
公开(公告)日：2012-11-22
申请号：US13462610
申请日：2012-05-02
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C07K14/43563 , C12N15/8218 , C12N15/8286 , C12N2310/14 , Y02A40/162
摘要： The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants, using interfering ribonucleic acid (RNA) molecules. The invention provides transgenic plants that (i) express or are capable of expressing interfering RNAs of the invention and (ii) are resistant to infestation by insect pest species.
摘要翻译： 本发明涉及使用干扰核糖核酸（RNA）分子的昆虫害虫侵染的遗传控制，特别是预防和/或控制植物害虫侵染。 本发明提供了（i）表达或能够表达本发明的干扰RNA的转基因植物，以及（ii）抗昆虫害虫侵染。
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公开(公告)号：US08906876B2
公开(公告)日：2014-12-09
申请号：US13592513
申请日：2012-08-23
申请人： Romaan Raemaekers , Laurent Kubler , Geert Karel Maria Plaetinck , Els Vanbleu , Thierry Andre Olivier Eddy Bogaert
发明人： Romaan Raemaekers , Laurent Kubler , Geert Karel Maria Plaetinck , Els Vanbleu , Thierry Andre Olivier Eddy Bogaert
CPC分类号： C07K14/43563 , A01N57/16 , A01N63/00 , A01N63/02 , A01N63/04 , A61K38/00 , C12N15/8218 , C12N15/8286 , Y02A40/162 , A01N25/00 , A01N2300/00
摘要： The present invention concerns methods for controlling insect infestation via RNAi-mediated gene silencing, whereby the intact insect cell(s) are contacted with a double-stranded RNA from outside the insect cell(s) and whereby the double-stranded RNA is taken up by the intact insect cell(s). In one particular embodiment, the methods of the invention are used to alleviate plants from insect pests. Alternatively, the methods are used for treating and/or preventing insect infestation on a substrate or a subject in need of such treatment and/or prevention. Suitable insect target genes and fragments thereof, dsRNA constructs, recombinant constructs and compositions are disclosed.
摘要翻译： 本发明涉及通过RNAi介导的基因沉默来控制昆虫侵袭的方法，其中完整的昆虫细胞与来自昆虫细胞外的双链RNA接触，由此将双链RNA吸收 通过完整的昆虫细胞。 在一个具体实施方案中，本发明的方法用于减轻植物害虫。 或者，所述方法用于治疗和/或预防对需要这种治疗和/或预防的基质或受试者的昆虫侵袭。 公开了合适的昆虫靶基因及其片段，dsRNA构建体，重组构建体和组合物。
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公开(公告)号：US20130058890A1
公开(公告)日：2013-03-07
申请号：US13592513
申请日：2012-08-23
申请人： Romaan Raemaekers , Laurent Kubler , Geert Karel Maria Plaetinck , Els Vanbleu , Thierry Andre Olivier Eddy Bogaert
发明人： Romaan Raemaekers , Laurent Kubler , Geert Karel Maria Plaetinck , Els Vanbleu , Thierry Andre Olivier Eddy Bogaert
IPC分类号： A01N63/04 , A61K35/74 , A61K36/06 , A01M1/20 , C12N1/19 , C07H21/04 , A01P21/00 , A01N63/02 , A01N25/00 , C12N1/21
CPC分类号： C07K14/43563 , A01N57/16 , A01N63/00 , A01N63/02 , A01N63/04 , A61K38/00 , C12N15/8218 , C12N15/8286 , Y02A40/162 , A01N25/00 , A01N2300/00
摘要： The present invention concerns methods for controlling insect infestation via RNAi-mediated gene silencing, whereby the intact insect cell(s) are contacted with a double-stranded RNA from outside the insect cell(s) and whereby the double-stranded RNA is taken up by the intact insect cell(s). In one particular embodiment, the methods of the invention are used to alleviate plants from insect pests. Alternatively, the methods are used for treating and/or preventing insect infestation on a substrate or a subject in need of such treatment and/or prevention. Suitable insect target genes and fragments thereof, dsRNA constructs, recombinant constructs and compositions are disclosed.
摘要翻译： 本发明涉及通过RNAi介导的基因沉默来控制昆虫侵袭的方法，其中完整的昆虫细胞与来自昆虫细胞外的双链RNA接触，由此将双链RNA吸收 通过完整的昆虫细胞。 在一个具体实施方案中，本发明的方法用于减轻植物害虫。 或者，所述方法用于治疗和/或预防对需要这种治疗和/或预防的基质或受试者的昆虫侵袭。 公开了合适的昆虫靶基因及其片段，dsRNA构建体，重组构建体和组合物。
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公开(公告)号：US09982258B2
公开(公告)日：2018-05-29
申请号：US14485103
申请日：2014-09-12
申请人： Romaan Raemaekers , Pascale Feldmann , Geert Plaetinck , Irene Nooren , Frederic Pecqueur , Laurent Kubler , Nicole Damme , Lies Degrave , Isabel Remory , Thierry Bogaert
发明人： Romaan Raemaekers , Pascale Feldmann , Geert Plaetinck , Irene Nooren , Els Van Bleu , Frederic Pecqueur , Laurent Kubler , Nicole Damme , Lies Degrave , Isabel Remory , Thierry Bogaert
IPC分类号： C12N15/11 , C12N15/113 , A01N63/02 , C12N15/82
CPC分类号： C12N15/113 , A01N63/02 , C12N15/8286 , C12N2310/14 , Y02A40/162
摘要： The present invention relates to methods for controlling pest infestation using double stranded RNA molecules. The invention provides methods for producing transgenic cells expressing the double stranded RNA molecules, as well as compositions and commodity products containing or treated with such molecules.
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公开(公告)号：US08853489B2
公开(公告)日：2014-10-07
申请号：US11992090
申请日：2006-09-18
申请人： Romaan Raemaekers , Pascale Feldmann , Irene Nooren , Geert Plaetinck , Frederic Pecqueur , Els Van Bleu , Thierry Bogaert
发明人： Romaan Raemaekers , Pascale Feldmann , Irene Nooren , Geert Plaetinck , Frederic Pecqueur , Els Van Bleu , Thierry Bogaert
CPC分类号： C12N15/8286 , A01N57/10 , C12N15/113 , C12N15/8218 , C12N15/8281 , C12N15/8282 , C12N15/8283 , C12N15/8285 , C12N2310/14 , Y02A40/162 , Y02A40/164
摘要： The present invention relates to methods for controlling pest infestation using double stranded RNA molecules. The invention provides methods for making transgenic plants that express the double stranded RNA molecules, as well as pesticidal agents and commodity products produced by the inventive plants. The invention also provides transgenic plants that are resistant to insect pest infestation.
摘要翻译： 本发明涉及使用双链RNA分子控制害虫侵染的方法。 本发明提供了用于制备表达双链RNA分子的转基因植物以及由本发明植物产生的杀虫剂和商品的方法。 本发明还提供了抗虫害侵染的转基因植物。
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公开(公告)号：US20090300796A1
公开(公告)日：2009-12-03
申请号：US11992090
申请日：2006-09-18
申请人： Romaan Raemaekers , Pascale Feldmann , Irene Nooren , Geert Plaetinck , Frederic Pecqueur , Els Van bleu
发明人： Romaan Raemaekers , Pascale Feldmann , Irene Nooren , Geert Plaetinck , Frederic Pecqueur , Els Van bleu
CPC分类号： C12N15/8286 , A01N57/10 , C12N15/113 , C12N15/8218 , C12N15/8281 , C12N15/8282 , C12N15/8283 , C12N15/8285 , C12N2310/14 , Y02A40/162 , Y02A40/164
摘要： The present invention relates to methods for controlling pest infestation using double stranded RNA molecules. The invention provides methods for making transgenic plants that express the double stranded RNA molecules, as well as pesticidal agents and commodity products produced by the inventive plants.
摘要翻译： 本发明涉及使用双链RNA分子控制害虫侵染的方法。 本发明提供了用于制备表达双链RNA分子的转基因植物以及由本发明植物产生的杀虫剂和商品的方法。
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