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公开(公告)号：US08906876B2
公开(公告)日：2014-12-09
申请号：US13592513
申请日：2012-08-23
申请人： Romaan Raemaekers , Laurent Kubler , Geert Karel Maria Plaetinck , Els Vanbleu , Thierry Andre Olivier Eddy Bogaert
发明人： Romaan Raemaekers , Laurent Kubler , Geert Karel Maria Plaetinck , Els Vanbleu , Thierry Andre Olivier Eddy Bogaert
CPC分类号： C07K14/43563 , A01N57/16 , A01N63/00 , A01N63/02 , A01N63/04 , A61K38/00 , C12N15/8218 , C12N15/8286 , Y02A40/162 , A01N25/00 , A01N2300/00
摘要： The present invention concerns methods for controlling insect infestation via RNAi-mediated gene silencing, whereby the intact insect cell(s) are contacted with a double-stranded RNA from outside the insect cell(s) and whereby the double-stranded RNA is taken up by the intact insect cell(s). In one particular embodiment, the methods of the invention are used to alleviate plants from insect pests. Alternatively, the methods are used for treating and/or preventing insect infestation on a substrate or a subject in need of such treatment and/or prevention. Suitable insect target genes and fragments thereof, dsRNA constructs, recombinant constructs and compositions are disclosed.
摘要翻译： 本发明涉及通过RNAi介导的基因沉默来控制昆虫侵袭的方法，其中完整的昆虫细胞与来自昆虫细胞外的双链RNA接触，由此将双链RNA吸收 通过完整的昆虫细胞。 在一个具体实施方案中，本发明的方法用于减轻植物害虫。 或者，所述方法用于治疗和/或预防对需要这种治疗和/或预防的基质或受试者的昆虫侵袭。 公开了合适的昆虫靶基因及其片段，dsRNA构建体，重组构建体和组合物。
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公开(公告)号：US20130058890A1
公开(公告)日：2013-03-07
申请号：US13592513
申请日：2012-08-23
申请人： Romaan Raemaekers , Laurent Kubler , Geert Karel Maria Plaetinck , Els Vanbleu , Thierry Andre Olivier Eddy Bogaert
发明人： Romaan Raemaekers , Laurent Kubler , Geert Karel Maria Plaetinck , Els Vanbleu , Thierry Andre Olivier Eddy Bogaert
IPC分类号： A01N63/04 , A61K35/74 , A61K36/06 , A01M1/20 , C12N1/19 , C07H21/04 , A01P21/00 , A01N63/02 , A01N25/00 , C12N1/21
CPC分类号： C07K14/43563 , A01N57/16 , A01N63/00 , A01N63/02 , A01N63/04 , A61K38/00 , C12N15/8218 , C12N15/8286 , Y02A40/162 , A01N25/00 , A01N2300/00
摘要： The present invention concerns methods for controlling insect infestation via RNAi-mediated gene silencing, whereby the intact insect cell(s) are contacted with a double-stranded RNA from outside the insect cell(s) and whereby the double-stranded RNA is taken up by the intact insect cell(s). In one particular embodiment, the methods of the invention are used to alleviate plants from insect pests. Alternatively, the methods are used for treating and/or preventing insect infestation on a substrate or a subject in need of such treatment and/or prevention. Suitable insect target genes and fragments thereof, dsRNA constructs, recombinant constructs and compositions are disclosed.
摘要翻译： 本发明涉及通过RNAi介导的基因沉默来控制昆虫侵袭的方法，其中完整的昆虫细胞与来自昆虫细胞外的双链RNA接触，由此将双链RNA吸收 通过完整的昆虫细胞。 在一个具体实施方案中，本发明的方法用于减轻植物害虫。 或者，所述方法用于治疗和/或预防对需要这种治疗和/或预防的基质或受试者的昆虫侵袭。 公开了合适的昆虫靶基因及其片段，dsRNA构建体，重组构建体和组合物。
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公开(公告)号：US20100170000A9
公开(公告)日：2010-07-01
申请号：US11666021
申请日：2005-10-25
申请人： Marc Van De Craen , Geert Karel Maria Plaetinck , Isabelle Vercauteren , Marc Georges Logghe , Thierry Andre Olivier Eddy Bogaert , Richard Zwaal
发明人： Marc Van De Craen , Geert Karel Maria Plaetinck , Isabelle Vercauteren , Marc Georges Logghe , Thierry Andre Olivier Eddy Bogaert , Richard Zwaal
IPC分类号： C12N15/82 , C12N15/11 , C12N15/00 , C12N5/04 , A61K31/7105 , C12N1/21 , C12N1/19 , A01N57/16
CPC分类号： C12N15/8285 , C12N15/111 , C12N15/113 , C12N15/8279 , C12N2310/14 , C12N2310/3519 , C12N2330/30
摘要： The present invention concerns concatemer and/or stabilized RNA constructs capable of forming dsRNA, optionally comprising a sequence capable of protecting the dsRNA against RNA processing in a host cell. The invention also relates to methods of producing these constructs and to methods for using these constructs. The constructs according to the present invention are particularly useful in plant pest control.
摘要翻译： 本发明涉及能够形成dsRNA的并联和/或稳定的RNA构建体，任选地包含能够保护dsRNA的宿主免受宿主细胞中RNA加工的序列。 本发明还涉及生产这些构建体的方法和使用这些构建体的方法。 根据本发明的构建体在植物害虫防治中特别有用。
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公开(公告)号：US20090126038A1
公开(公告)日：2009-05-14
申请号：US11666021
申请日：2005-10-25
申请人： Marc Van De Craen , Geert Karel Maria Plaetinck , Isabelle Vercauteren , Marc Georges Logghe , Thierry Andre Olivier Eddy Bogaert , Richard Zwaal
发明人： Marc Van De Craen , Geert Karel Maria Plaetinck , Isabelle Vercauteren , Marc Georges Logghe , Thierry Andre Olivier Eddy Bogaert , Richard Zwaal
CPC分类号： C12N15/8285 , C12N15/111 , C12N15/113 , C12N15/8279 , C12N2310/14 , C12N2310/3519 , C12N2330/30
摘要： The present invention concerns concatemer and/or stabilized RNA constructs capable of forming dsRNA, optionally comprising a sequence capable of protecting the dsRNA against RNA processing in a host cell. The invention also relates to methods of producing these constructs and to methods for using these constructs. The constructs according to the present invention are particularly useful in plant pest control.
摘要翻译： 本发明涉及能够形成dsRNA的并联和/或稳定的RNA构建体，任选地包含能够保护dsRNA的宿主免受宿主细胞中RNA加工的序列。 本发明还涉及生产这些构建体的方法和使用这些构建体的方法。 根据本发明的构建体在植物害虫防治中特别有用。
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公开(公告)号：US09206438B2
公开(公告)日：2015-12-08
申请号：US13462636
申请日：2012-05-02
IPC分类号： C12N15/82 , C07K14/435
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C07K14/43563 , C12N15/8218 , C12N15/8286 , C12N2310/14 , Y02A40/162
摘要： The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants, using interfering ribonucleic acid (RNA) molecules. Compositions and combinations containing the interfering RNA molecules of the invention for use in topical applications, for example in the form of insecticides.
摘要翻译： 本发明涉及使用干扰核糖核酸（RNA）分子的昆虫害虫侵染的遗传控制，特别是预防和/或控制植物害虫侵染。 含有用于局部应用的本发明的干扰RNA分子的组合物和组合，例如以杀虫剂的形式。
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公开(公告)号：US20120322660A1
公开(公告)日：2012-12-20
申请号：US13462636
申请日：2012-05-02
IPC分类号： A01N57/16 , C12N15/11 , C12N15/63 , A01P13/00 , A01P7/04 , A01N63/00 , A01N37/46 , C07H21/02 , C12N1/21
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C07K14/43563 , C12N15/8218 , C12N15/8286 , C12N2310/14 , Y02A40/162
摘要： The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants, using interfering ribonucleic acid (RNA) molecules. Compositions and combinations containing the interfering RNA molecules of the invention for use in topical applications, for example in the form of insecticides.
摘要翻译： 本发明涉及使用干扰核糖核酸（RNA）分子的昆虫害虫侵染的遗传控制，特别是预防和/或控制植物害虫侵染。 含有用于局部应用的本发明的干扰RNA分子的组合物和组合，例如以杀虫剂的形式。
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公开(公告)号：US09845479B2
公开(公告)日：2017-12-19
申请号：US13462610
申请日：2012-05-02
IPC分类号： C12N15/82 , C12N15/113 , C07K14/435
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C07K14/43563 , C12N15/8218 , C12N15/8286 , C12N2310/14 , Y02A40/162
摘要： The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants, using interfering ribonucleic acid (RNA) molecules. The invention provides transgenic plants that (i) express or are capable of expressing interfering RNAs of the invention and (ii) are resistant to infestation by insect pest species.
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公开(公告)号：US20130231246A9
公开(公告)日：2013-09-05
申请号：US13462636
申请日：2012-05-02
IPC分类号： A01N57/16 , C12N15/11 , C12N15/63 , A01P13/00 , A01P7/04 , A01N63/00 , A01N37/46 , C07H21/02 , C12N1/21
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C07K14/43563 , C12N15/8218 , C12N15/8286 , C12N2310/14 , Y02A40/162
摘要： The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants, using interfering ribonucleic acid (RNA) molecules. Compositions and combinations containing the interfering RNA molecules of the invention for use in topical applications, for example in the form of insecticides.
摘要翻译： 本发明涉及使用干扰核糖核酸（RNA）分子的昆虫害虫侵染的遗传控制，特别是预防和/或控制植物害虫侵染。 含有用于局部应用的本发明的干扰RNA分子的组合物和组合，例如以杀虫剂的形式。
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公开(公告)号：US20120297501A1
公开(公告)日：2012-11-22
申请号：US13462610
申请日：2012-05-02
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C07K14/43563 , C12N15/8218 , C12N15/8286 , C12N2310/14 , Y02A40/162
摘要： The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants, using interfering ribonucleic acid (RNA) molecules. The invention provides transgenic plants that (i) express or are capable of expressing interfering RNAs of the invention and (ii) are resistant to infestation by insect pest species.
摘要翻译： 本发明涉及使用干扰核糖核酸（RNA）分子的昆虫害虫侵染的遗传控制，特别是预防和/或控制植物害虫侵染。 本发明提供了（i）表达或能够表达本发明的干扰RNA的转基因植物，以及（ii）抗昆虫害虫侵染。
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公开(公告)号：US20100311819A1
公开(公告)日：2010-12-09
申请号：US12778278
申请日：2010-05-12
申请人： Marc Van De Craen , Phuay-Yee Goh , Marc Georges Logghe , Yee-Ling Khu , Katherine Mortier , Thierry Andre Olivier Eddy Bogaert
发明人： Marc Van De Craen , Phuay-Yee Goh , Marc Georges Logghe , Yee-Ling Khu , Katherine Mortier , Thierry Andre Olivier Eddy Bogaert
CPC分类号： A01N57/16 , A01N63/02 , A01N63/04 , C07K14/37 , C12N15/113 , C12N15/8218 , C12N15/8282 , C12N2310/14
摘要： The present invention concerns methods for controlling fungus infestation via dsRNA mediated gene silencing, whereby the intact fungus cell(s) are contacted with a double-stranded RNA from outside the fungal cell(s) and whereby the double-stranded RNA is taken up by the intact fungal cell(s). In one particular embodiment, the methods of the invention are used to alleviate plants from fungus pests. Alternatively, the methods are used for treating and/or preventing fungal infestation on a substrate or a subject in need of such treatment and/or prevention. Suitable fungal target genes and fragments thereof, dsRNA constructs, recombinant constructs and compositions are disclosed.
摘要翻译： 本发明涉及通过dsRNA介导的基因沉默来控制真菌感染的方法，其中完整的真菌细胞与来自真菌细胞外的双链RNA接触，由此双链RNA被 完整的真菌细胞。 在一个具体实施方案中，本发明的方法用于减轻植物从真菌害虫中的减少。 或者，所述方法用于治疗和/或预防对需要这种治疗和/或预防的基质或受试者的真菌侵袭。 公开了合适的真菌靶基因及其片段，dsRNA构建体，重组构建体和组合物。
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