公开(公告)号：US20240263213A1

公开(公告)日：2024-08-08

申请号：US18683730

申请日：2022-08-16

Applicant: NAGI BIOSCIENCE SA

Inventor： Matteo CORNAGLIA ,  Fabien TACHE

IPC: C12Q1/18 ,  C12M1/00 ,  C12M1/34 ,  C12M1/36

CPC classification number: C12Q1/18 ,  C12M23/34 ,  C12M29/06 ,  C12M41/46 ,  C12M41/48

Abstract: Microscopic worm culture and observation apparatus (1) comprising a support structure (10), one or more chip holders (3) mounted on the support structure, a pump (P) and a valve system (V), each chip holder configured for holding a microfluidic chip (2) having one or more microfluidic channels (54) and culture chambers (52) therein extending between a pump side coupling (44a) of the microfluidic chip and a reservoir side coupling (44b) of the microfluidic chip. The support structure comprises a reservoirs support platform (7) mounted on a movable table (12), the reservoirs support platform (7) configured for holding a plurality of nutrition reservoirs (5) for containing microscopic worms or nutrients and substances to be tested in a liquid. The chip holder (3) and/or microfluidic chips (2) comprise reservoir side fluidic couplings (26) in the form of hollow tubes extending from the microfluidic chip (2) to a tip (26b) at a free end of the hollow tube, each tip (26b) insertable in a corresponding nutrition reservoir (5). The support structure comprises an enclosure (15) forming a chamber within which the one or more chip holders and the reservoirs support platform is housed, and a temperature control unit (19) and a temperature sensor (23) for control of the temperature within the chamber, the enclosure comprising an openable or removable cover (17) allowing access to the inside of the enclosure.

公开(公告)号：US20240263117A1

公开(公告)日：2024-08-08

申请号：US18683715

申请日：2022-08-16

Applicant: Nagi Bioscience SA

Inventor： Matteo CORNAGLIA ,  Fabien TACHE

IPC: C12M3/06 ,  B01L3/00 ,  C12M1/00 ,  C12M1/12 ,  C12M3/00 ,  G02B21/00 ,  G06T7/00

CPC classification number: C12M23/16 ,  B01L3/502723 ,  C12M23/34 ,  C12M23/48 ,  C12M25/10 ,  C12M27/16 ,  C12M31/00 ,  G02B21/0004 ,  G06T7/0012 ,  B01L2200/0684 ,  G06T2207/10056

Abstract: Microscopic biological organism culture and observation apparatus (1) comprising a support structure (10), one or more chip holders (3) mounted on the support structure, a pump (P) and a valve system (V), each chip holder configured for holding a microfluidic chip (2) having one or more microfluidic channels (54) and culture chambers (52) therein extending between a pump coupling side (44a) of the microfluidic chip and a reservoir side coupling (44b) of the microfluidic chip. The support structure comprises a reservoirs support platform (7) mounted on a movable table (12), the reservoirs support platform (7) configured for holding a plurality of nutrition reservoirs (5) for containing microscopic biological organisms or nutrients and substances to be tested in a liquid. The chip holder (3) and/or microfluidic chips (2) comprise reservoir side fluidic couplings (26) in the form of hollow tubes extending from the microfluidic chip (2) to a tip (26b) at a free end of the hollow tube, each tip (26b) insertable in a corresponding nutrition reservoir