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公开(公告)号：US20180245032A1
公开(公告)日：2018-08-30
申请号：US15970092
申请日：2018-05-03
申请人： NIKKISO CO., LTD.
发明人： Fumihiko KITAGAWA
CPC分类号： C12M25/06 , C07K14/705 , C07K14/78 , C12M25/00 , C12M25/10 , C12N5/0068 , C12N5/0686 , C12N2533/52
摘要： A cell support composite includes: a substrate formed of an artificial material; a laminin molecule or a fragment thereof which adheres to at least a part of the substrate; and a renal tubule epithelial cell or a renal tubule epithelial-like cell which is a culture cell attached to the substrate via the laminin molecule or the fragment thereof.
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公开(公告)号：US09932559B2
公开(公告)日：2018-04-03
申请号：US13679510
申请日：2012-11-16
发明人： Andrew D. Wong , Peter C. Searson
CPC分类号： C12N5/0691 , A61F2/062 , C12M21/08 , C12M25/10 , C12M25/14 , C12M29/10 , C12N5/0068 , C12N5/069 , C12N2533/30 , C12N2533/90
摘要： A platform for creating an artificial blood brain barrier including a functional, perfused artificial vessel lined with endothelial cells embedded in a physiologically relevant three-dimensional extracellular matrix is described.
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公开(公告)号：US20180066220A1
公开(公告)日：2018-03-08
申请号：US15697306
申请日：2017-09-06
申请人： Pulak Nath , Jen-Huang Huang
发明人： Pulak Nath , Jen-Huang Huang
CPC分类号： C12M23/16 , C12M21/08 , C12M23/26 , C12M25/10 , C12M25/14 , C12M29/10 , C12M33/12 , C12M35/04 , C12M35/08 , C12M41/40 , C12N5/0697 , C12N2502/095 , C12N2502/1305 , C12N2502/1323 , C12N2502/27 , C12N2502/28 , C12N2502/30 , C12N2521/00 , C12N2533/78 , G01N33/5032
摘要： Devices and systems for cell culture that include one or more hollow fibers or channels integrated into a chamber are provided. The hollow fibers or channels and/or the chamber are seeded with one or more cell types. Methods of co-culturing two or more cell types in the devices are also provided.
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公开(公告)号：US09902939B2
公开(公告)日：2018-02-27
申请号：US13120323
申请日：2009-09-23
申请人： David Luttropp , Markus Neubauer , Helmut Geiger , Juergen Bereiter-Hahn , Patrick Baer , Reinhold Deppisch , Doris Deppisch
发明人： David Luttropp , Markus Neubauer , Helmut Geiger , Juergen Bereiter-Hahn , Patrick Baer , Reinhold Deppisch , Doris Deppisch
CPC分类号： C12N5/0686 , B01D71/42 , B01D71/68 , C12M21/08 , C12M25/10 , C12M29/16 , C12N2533/30
摘要： A device for culturing, storing and expanding adherent renal cells. The device permits the adhesion and proliferation of the cells and the surface characteristics of the membrane material used in said device further permit the cellular matrix components (EMC). A method for expanding adherent renal cells and methods of using particular membranes for culturing, storing and expanding adherent renal cells. The membranes comprise a copolymer of acrylonitrile and sodium methallyl sulfonate as well as polyethylenimine.
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公开(公告)号：US20180030406A1
公开(公告)日：2018-02-01
申请号：US15656539
申请日：2017-07-21
申请人： Bobban Subhadra
发明人： Bobban Subhadra
IPC分类号： C12N1/20 , A61K9/00 , A61K35/74 , C12N1/04 , C12M1/34 , C12M1/00 , C12M3/00 , C12M1/12 , C12N7/00 , A61K35/00
CPC分类号： C12N1/20 , A61K9/0031 , A61K9/0053 , A61K35/74 , A61K2035/11 , C12M23/02 , C12M23/06 , C12M23/20 , C12M23/42 , C12M25/10 , C12M41/12 , C12M41/14 , C12M41/34 , C12N1/04 , C12N7/00 , C12N2795/00032 , C12N2795/00051 , C12R1/01 , C12R1/145 , C12R1/19 , C12R1/46 , G01N33/558
摘要： One embodiment provides a commensal gut production platform for ex vivo production of human gut commensal microbiota. Another embodiment provides devices, systems and methods for ex vivo culturing of gut microflora in a system that mimics the human gut environment. The culturing of the commensal microbiota in the disclosed systems produces gut microbiota having defined characteristics and properties that can be exploited to treat various conditions in a subject.
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公开(公告)号：US20170292103A1
公开(公告)日：2017-10-12
申请号：US15485866
申请日：2017-04-12
CPC分类号： C12M29/10 , B01D61/14 , B01D61/18 , B01D61/20 , B01D63/02 , B01D63/06 , B01D71/26 , B01D2315/10 , C07K2317/10 , C12M25/10 , C12M29/04 , C12M29/16 , C12N5/00
摘要： Provided herein are tubular membrane filter elements, tangential flow filtration systems comprising such filter elements and methods of using such filter elements and filtration systems.
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公开(公告)号：US09670451B2
公开(公告)日：2017-06-06
申请号：US14548617
申请日：2014-11-20
申请人： Terumo BCT, Inc.
发明人： Thomas G. Dilorenzo , Edward Allan Stanton, IV , Glen Delbert Antwiler , Michael E. Kinzie , Brian J. Nankervis , Monique Givens , Casey V. Medina , Jon A. Dodd
CPC分类号： C12M41/44 , C12M23/42 , C12M23/44 , C12M25/10 , C12M25/12 , C12M29/16 , C12M29/20 , C12M41/48 , G06F8/38
摘要： Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.
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公开(公告)号：US09618500B2
公开(公告)日：2017-04-11
申请号：US13924665
申请日：2013-06-24
摘要： A vascular model includes at least one microchannel perfusable by at least one fluid and in a form of a hollow structure having a wall thickness in a range from 0.1 μm to 1000 μm, a concave inner surface with a cross-section which is circular in part and at least one pore having a diameter in a range from 1 nm to 100 μm. The at least one microchannel has a width in a range from 0.01 μm to 10 mm and a depth in a range from 0.01 μm to 10 mm. At least one chamber is perfusable by a same and/or different fluid and surrounds the at least one microchannel over an entire length and width or over parts thereof. The at least one chamber adjoins the at least one microchannel. At least one connector is configured to receive and/or discharge the at least one fluid.
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公开(公告)号：US20170022472A1
公开(公告)日：2017-01-26
申请号：US15267802
申请日：2016-09-16
申请人： ReGenesys BVBA
IPC分类号： C12N5/00 , A61K35/28 , C12N5/0775
CPC分类号： C12N5/0068 , A61K35/28 , C12M21/08 , C12M23/06 , C12M25/10 , C12M29/10 , C12M29/16 , C12M33/04 , C12N5/0663 , C12N2513/00 , C12N2533/52
摘要： The invention is directed to producing large numbers of cells using hollow fiber bioreactor technology. The cells are non-embryonic stem, non-germ cells that can be characterized by one or more of the following: extended replication in culture and markers of extended replication, such as telomerase, markers of pluripotentiality, and broad differentiation potential, without being transformed.
摘要翻译： 本发明涉及使用中空纤维生物反应器技术生产大量细胞。 细胞是非胚胎干，非生殖细胞，其可以通过以下一个或多个来表征：培养中的扩展复制和扩展复制的标记，例如端粒酶，多能性标记和广泛的分化潜能，而不被转化 。
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公开(公告)号：US09260698B2
公开(公告)日：2016-02-16
申请号：US14336719
申请日：2014-07-21
申请人： Terumo BCT, Inc.
CPC分类号： C12N5/0663 , C12M25/10 , C12M25/12 , C12M29/10 , C12M29/16 , C12M41/00 , C12N2521/00
摘要： Cell expansion systems and methods of use are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second circulation loops (intracapillary loops and extracapillary loops) associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. Detachable flow circuits and methods of expanding cells are also provided.
摘要翻译： 提供电池膨胀系统和使用方法。 细胞扩增系统通常包括中空纤维细胞生长室，以及分别与中空纤维内部和中空纤维外部相关联的第一和第二循环回路（毛细管内毛细管环和毛细血管外循环）。 还提供了可拆卸的流动电路和膨胀电池的方法。
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