公开(公告)号：US20230059836A1

公开(公告)日：2023-02-23

申请号：US17818942

申请日：2022-08-10

申请人： Nanjing Legend Biotech Co., Ltd.

发明人： Chuan-Chu CHOU ,  Yafeng ZHANG ,  Shu WU ,  Zhenyu LIU ,  Zhongdao LI ,  Fangliang ZHANG

IPC分类号： C07K16/46 ,  A61P35/00 ,  C07K16/28 ,  A61P37/00 ,  A61P29/00 ,  C07K16/24 ,  C07K16/30

摘要： Disclosed herein are multispecific, such as bispecific, antigen binding proteins comprising a first antigen binding domain comprising a heavy chain variable domain and a light chain variable domain, and a second antigen binding domain comprising a single-domain antibody. Pharmaceutical compositions comprising the multispecific antigen binding proteins, kits and methods of use thereof are further provided.

公开(公告)号：US20190202935A1

公开(公告)日：2019-07-04

申请号：US16319224

申请日：2017-07-20

申请人： NANJING LEGEND BIOTECH CO., LTD.

发明人： Chuan-Chu CHOU ,  Yafeng ZHANG ,  Shu WU ,  Zhenyu LIU ,  Zhongdao LI ,  Fangliang ZHANG

IPC分类号： C07K16/46 ,  C07K16/30 ,  C07K16/24 ,  A61P37/00 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07K16/46 ,  A61K2039/505 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07K16/24 ,  C07K16/2818 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/31

摘要： Disclosed herein are multispecific, such as bispecific, antigen binding proteins comprising a first antigen binding domain comprising a heavy chain variable domain and a light chain variable domain, and a second antigen binding domain comprising a single-domain antibody. Pharmaceutical compositions comprising the multispecific antigen binding proteins, kits and methods of use thereof are further provided.