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公开(公告)号：US20200147231A1
公开(公告)日：2020-05-14
申请号：US16609668
申请日：2018-04-27
摘要： The present invention relates to an antibody-drug conjugate (ADC) and a composition containing the conjugate for use in treating cancer. According to the present invention, provided are an ADC of an antibody specific to insoluble fibrin and a drug in which a linker linking the antibody and the drug has a plasmin cleavage sequence, and a pharmaceutical composition containing the ADC for use in treating cancer.
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公开(公告)号：US20210221911A1
公开(公告)日：2021-07-22
申请号：US16760539
申请日：2018-10-29
摘要： The present invention provides an antibody beneficial for treatment of a solid tumor, an antibody-drug conjugate thereof, and an anticancer agent comprising these. The present invention provides, for example, an antibody that binds to tissue factor or an antigen-binding fragment thereof, wherein the antibody has a dissociation rate constant kd of 5×10−4 s−1 or more and an association rate constant Ka of 1×104 M−1s−1 or more.
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公开(公告)号：US20240148893A1
公开(公告)日：2024-05-09
申请号：US18178854
申请日：2023-03-06
发明人： Yasuhiro MATSUMURA , Masahiro Yasunaga , Shinji Saijou , Shingo Hanaoka , Takahiro Anzai , Shino Manabe
IPC分类号： A61K47/68 , A61K39/395 , A61K49/00 , A61P35/00 , C07K16/30 , C12N5/10 , C12N15/09 , C12N15/62 , G01N33/574
CPC分类号： A61K47/6851 , A61K39/395 , A61K49/00 , A61P35/00 , C07K16/30 , C12N5/10 , C12N15/09 , C12N15/62 , G01N33/574 , G01N33/57419
摘要： An object of the present invention is to provide an anticancer drug capable of treating cancer by finding a target molecule specifically expressed in cancer cells and by specifically acting on the target molecule, and to provide a cancer testing method including a step of measuring the target molecule in a sample. The present invention provides an anticancer drug containing, as an active ingredient thereof, an anti-transmembrane protein 180 (TMEM-180) antibody or an antigen-binding fragment thereof. In addition, the present invention provides a cancer testing method including a step of measuring the amount of TMEM-180 in a sample collected from a subject.
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公开(公告)号：US20190060480A1
公开(公告)日：2019-02-28
申请号：US16083077
申请日：2017-03-07
发明人： Yasuhiro MATSUMURA , Masahiro YASUNAGA , Shinji SAIJO , Shingo HANAOKA , Takahiro ANZAI , Shino MANABE
IPC分类号： A61K47/68 , A61P35/00 , C12N15/62 , C07K16/30 , G01N33/574
摘要： An object of the present invention is to provide an anticancer drug capable of treating cancer by finding a target molecule specifically expressed in cancer cells and by specifically acting on the target molecule, and to provide a cancer testing method including a step of measuring the target molecule in a sample. The present invention provides an anticancer drug containing, as an active ingredient thereof, an anti-transmembrane protein 180 (TMEM-180) antibody or an antigen-binding fragment thereof. In addition, the present invention provides a cancer testing method including a step of measuring the amount of TMEM-180 in a sample collected from a subject.
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公开(公告)号：US20190225704A1
公开(公告)日：2019-07-25
申请号：US16325315
申请日：2017-08-14
IPC分类号： C07K16/30 , G01N33/574 , A61K47/68
摘要： [Problem]The present invention provides an antibody that binds to TMEM132A, an anticancer agent and a cancer test method.[Solution]An antibody that binds to TMEM132A.
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6.发明公开公开(公告)号：US20240218058A1
公开(公告)日：2024-07-04
申请号：US17915905
申请日：2021-03-30
发明人： Yasuhiro MATSUMURA , Shingo HANAOKA , Shinji SAIJO
CPC分类号： C07K16/18 , A61P9/10 , C12N9/6462 , A61K38/00 , C07K2317/565 , C07K2319/50
摘要： The present invention provides a fusion protein suitable for dissolving a fibrin clot and a pharmaceutical composition containing the fusion protein. According to the present invention, there is provided a fusion protein of an antibody that binds to insoluble fibrin or an antigen-binding fragment thereof and a prourokinase mutant, in which amino acid sequence of a plasmin in a kringle domain is modified so as to be less cleavable with a plasmin, and a pharmaceutical composition containing the fusion protein.
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公开(公告)号：US20240261424A1
公开(公告)日：2024-08-08
申请号：US17915982
申请日：2021-03-16
发明人： Yasuhiro MATSUMURA , Ryo TSUMURA
CPC分类号： A61K47/6849 , A61K47/68037 , A61K47/6889 , A61P35/00 , C07K16/36
摘要： The present invention relates to an antibody drug conjugate in which an antibody that binds to tissue factor and Dxd that is the cytotoxic agent are bound via a linker composed of maleimide caproyl-glycine-glycine-phenylalanine-glycine.
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公开(公告)号：US20230132177A1
公开(公告)日：2023-04-27
申请号：US17915885
申请日：2021-03-30
发明人： Yasuhiro MATSUMURA , Shingo HANAOKA , Shinji SAIJO
摘要： The present invention provides an antibody that binds to fibrin and a pharmaceutical composition containing the antibody. According to the present invention, there is particularly provided a humanized antibody that binds to fibrin and a pharmaceutical composition containing the antibody.
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