公开(公告)号：US20150352209A1

公开(公告)日：2015-12-10

申请号：US14759758

申请日：2014-01-10

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Mitsuhiro EBARA ,  Takao AOYAGI ,  Koichiro UTO

IPC: A61K41/00 ,  D01D5/00 ,  A61K47/32 ,  D04H1/728 ,  A61K9/70

CPC classification number: A61K41/0052 ,  A61K9/7007 ,  A61K9/7061 ,  A61K33/00 ,  A61K33/26 ,  A61K33/44 ,  A61K47/32 ,  C08F220/56 ,  C08L33/24 ,  D01D5/0007 ,  D01D5/003 ,  D01F1/10 ,  D01F6/28 ,  D01F6/30 ,  D04H1/413 ,  D04H1/728 ,  D10B2321/10 ,  D10B2401/10 ,  D10B2509/00 ,  C08F220/54 ,  C08F220/58

Abstract: The invention aims to provide a nanofiber having self-heating properties and biologically active substance release properties, which can release a drug at the same time as self-heating, and can be safely used on a human body without diffusing self-heating nanoparticles, a production method for the same, and a nonwoven fabric having self-heating properties and biologically active substance release capabilities. A fiber is provided having a diameter in a range of 50 nm to 50 μm, and a length of 100 times the diameter or more, the fiber including: self-heating particles that generate heat in response to stimulation from outside; a stimulation-responsive polymer of which physical properties change by directly or indirectly reacting due to the stimulation; and a biologically active substance that is held by the stimulation-responsive polymer, in which the biologically active substance is released to the outside in response to the changes in the physical properties of the stimulation-responsive polymer, a production method for the same, and a nonwoven fabric having self-heating properties and biologically active substance release capabilities.

Abstract translation: 本发明的目的在于提供具有自热特性和生物活性物质释放性质的纳米纤维，其能够在自加热的同时释放药物，并且可以安全地使用在人体上而不扩散自加热纳米颗粒， 以及具有自热性和生物活性物质释放能力的无纺布。 提供的纤维的直径在50nm至50μm的范围内，长度为直径或以上的100倍，纤维包括：响应于来自外部的刺激产生热量的自加热颗粒; 刺激响应性聚合物，其物理性质由于刺激而直接或间接反应而改变; 以及由刺激响应性聚合物保持的生物活性物质，其中响应于刺激响应性聚合物的物理性质的变化而将生物活性物质释放到外部，其生产方法和 具有自热特性和生物活性物质释放能力的无纺织物。

公开(公告)号：US20210140081A1

公开(公告)日：2021-05-13

申请号：US17257043

申请日：2019-07-09

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE ,  NIPPON ZOKI PHARMACEUTICAL CO., LTD.

Inventor： Koichiro UTO ,  Mitsuhiro EBARA ,  Mitsuru NAIKI ,  Takafumi KONISHI ,  Hitoshi YAMAMOTO

IPC: D04H1/728 ,  D04H1/55

Abstract: A non-woven fabric including fibers including an aliphatic polyester that has at least two maximum values in a molecular weight distribution thereof, wherein the fibers have a fiber diameter falling within the range of 100 to 3000 nm. The non-woven fabric of the present invention has excellent biodegradability.