公开(公告)号：US20170296479A1

公开(公告)日：2017-10-19

申请号：US15508094

申请日：2015-08-31

Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Fukue NAGATA ,  Katsuya KATO ,  Masahiko INAGAKI

IPC: A61K9/51 ,  A61K9/50 ,  A61K47/34

Abstract: Provided are core-shell particles which are kept stable in a solvent such as water for a long period. Each core-shell particle includes a core which contains a hydrophobic polymer having an anionic group and a shell which contains calcium phosphate. At least one of calcium atoms contained in calcium phosphate is chemically bonded to a functional group derived from the anionic group. In a method of manufacturing core-shell particles each core-shell particle includes a core which contains a hydrophobic polymer and a shell which contains calcium phosphate, the method includes the steps of: mixing a water-soluble organic solution which contains a hydrophobic polymer having an anionic group with a solution which contains calcium ion so as to obtain a first mixed solution; mixing the first mixed solution with a solution which contains phosphate ions so as to obtain a second mixed solution; and stirring the second mixed solution.

公开(公告)号：US20220119498A1

公开(公告)日：2022-04-21

申请号：US17424691

申请日：2020-01-17

Applicant: NGK Spark Plug Co., LTD. ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Katsuya KATO ,  Fukue NAGATA ,  Shinjiro KASAHARA ,  Yuki HIROBE ,  Jun OTSUKA

IPC: C07K16/00 ,  C07K1/30

Abstract: To provide an immunoglobulin purification method which achieves a high immunoglobulin recovery percentage without causing loss of the antibody nature of an immunoglobulin. The immunoglobulin purification method includes an adsorption step and a desorption step. The adsorption step involves adsorption of an immunoglobulin onto porous zirconia particles in a neutral buffer. The desorption step involves desorption of the immunoglobulin adsorbed on the porous zirconia particles from the porous zirconia particles by means of a neutral desorption liquid.

公开(公告)号：US20220089453A1

公开(公告)日：2022-03-24

申请号：US17424640

申请日：2020-01-17

Applicant: NGK Spark Plug Co., LTD. ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Katsuya KATO ,  Fukue NAGATA ,  Shinjiro KASAHARA ,  Jun OTSUKA ,  Yuki HIROBE

IPC: C01G25/02 ,  B01J20/06 ,  B01J20/28

Abstract: Porous zirconia particles exhibit high specificity to a protein to be immobilized thereto and are used in immobilization of the protein. The porous zirconia particles have a pore diameter D50, at which a ratio of a cumulative pore volume to a total pore volume is 50%, the pore diameter D50 being in a range of 3.20 nm or more and 6.50 nm or less; and a pore diameter D90, at which a ratio of a cumulative pore volume to a total pore volume is 90%, the pore diameter D90 being in a range of 10.50 nm or more and 100.00 nm or less. The total pore volume of the particles is greater than 0.10 cm3/g. D50, D90, and the total pore volume are determined based on a pore diameter distribution measured through a BET method.

公开(公告)号：US20200216629A1

公开(公告)日：2020-07-09

申请号：US16482711

申请日：2018-01-29

Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Fukue NAGATA ,  Tatsuya MIYAJIMA ,  Katsuya KATO

IPC: C08J7/06 ,  C08J3/205 ,  C01B25/32

Abstract: Provided is a composite body where ceramic crystals are thinly and uniformly coated onto a base material containing a hydrophilic polymer. The composite body has a base material containing a hydrophilic polymer, and a ceramic layer which is coated onto at least a portion of a surface of the base material, and the ceramic layer contains crystals having a laminated structure. The ceramic layer may contain calcium phosphate. A thickness of the ceramic layer is 0.3 nm to 50 nm. The composite body is produced through a step of mixing and stirring a dispersion liquid in which the base material is dispersed, a first solution containing calcium ions, and a second solution containing phosphate ions.