公开(公告)号：US20150267178A1

公开(公告)日：2015-09-24

申请号：US14425837

申请日：2013-09-09

Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Kazumichi Ozawa ,  Noriko Sasaki ,  Atsunori Hiratsuka ,  Kenji Yokoyama ,  Nao Kinoshita ,  Hideaki Ooe ,  Jun Takagi ,  Koji Tanaka ,  Katsushige Kotani

IPC: C12N9/04 ,  C12Q1/54

CPC classification number: C12N9/0006 ,  C12Q1/006 ,  C12Q1/54 ,  C12Y101/9901 ,  G01N2333/904 ,  H01M4/90 ,  H01M8/16 ,  Y02E60/527

Abstract: The present invention provides a protein derived from a thermophilic filamentous fungus having flavin adenine dinucleotide-dependent glucose dehydrogenase activity. The present invention provides an enzyme for glucose measurement that has better thermal stability than that of conventional enzymes while being unaffected by dissolved oxygen, not requiring the addition of a coenzyme, and maintaining the excellent properties of FADGDH in terms of having excellent substrate specificity (particularly low reactivity with maltose).

Abstract translation: 本发明提供衍生自具有黄素腺嘌呤二核苷酸依赖性葡萄糖脱氢酶活性的嗜热丝状真菌的蛋白质。 本发明提供了一种具有比常规酶更好的热稳定性的酶的葡萄糖测定酶，而不受溶解氧的影响，不需要加入辅酶，并且在具有优异的底物特异性（特别是，特别是）的情况下，保持了FADGDH的优异性能 低麦芽糖的反应性）。

公开(公告)号：US20150148226A1

公开(公告)日：2015-05-28

申请号：US14610089

申请日：2015-01-30

Applicant: TANITA CORPORATION ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Narushi Ito ,  Jun Kimura ,  Masayuki Mizushina ,  Yohei Inaba ,  Kenji Yokoyama

IPC: B01J20/287 ,  B01J20/28

CPC classification number: B01J20/287 ,  B01D15/325 ,  B01D15/362 ,  B01J20/28004

Abstract: Aimed at readily and exactly separate 8-hydroxy-2′-deoxyguanosine (8-OHdG) contained in a sample, a column packing material used for separating 8-OHdG, which contains a packing material composed of a material having a straight-chain hydrocarbon group having 6 or more and 30 or less carbon atoms as a functional group, and having a carbon content over the surface of carrier of 18% or less by element ratio, wherein the packing material contains 1 cumulative percent or more and 20 cumulative percent or less, on the particle-count basis, of particles having a circle-equivalent diameter, measured using a flow-type particle image analyzer, of 0.5 μm or larger and 10 μm or smaller, is used.

Abstract translation: 针对样品中所含的8-羟基-2'-脱氧鸟苷（8-OHdG）容易且精确地分离，用于分离8-OHdG的柱填充材料，其包含由具有直链烃的材料组成的包装材料 具有6个或更多和30个或更少碳原子的官能团，并且在载体表面上的碳含量超过18％或更少的元素比，其中包装材料包含1个累积百分比或更多和20个累积百分比，或 使用0.5μm以上且10μm以下的使用流动型粒子图像分析仪测定的具有圆当量直径的粒子，以粒子计数为基准。