公开(公告)号：US10159642B2

公开(公告)日：2018-12-25

申请号：US15317885

申请日：2015-06-12

Applicant: SEED CO., LTD. ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Yoshiko Yamazaki ,  Takao Sato ,  Wuxiao Ding ,  Mitsutoshi Masuda ,  Momoyo Wada

IPC: A61K9/00 ,  A61L27/00 ,  A61K9/06 ,  A61K47/30 ,  A61K47/36 ,  A61K47/42 ,  C08F6/00 ,  A61K31/352 ,  A61K31/5415 ,  A61K47/32 ,  G02B1/04 ,  A61K9/50

Abstract: The purpose of the present invention is to provide: a functional polymer gel which is able to be practically used as an ocular lens having excellent transparency and mechanical strength by uniformly dispersing organic nanotubes in a polymer gel without the formation of agglomerates of the organic nanotubes in the case where the organic nanotubes are complexed into the polymer gel; and a method for producing this functional polymer gel. The above-mentioned purpose is achieved by: a functional polymer gel which is characterized by containing organic nanotubes and having a light transmittance of 80% or more; and a method for producing this functional polymer gel.

公开(公告)号：US20140147476A1

公开(公告)日：2014-05-29

申请号：US14116182

申请日：2012-03-30

Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Noahiro Kameta ,  Wuxiao Ding ,  Mitsutoshi Masuda ,  Hiroyuki Minamikawa ,  Momoyo Wada ,  Toshimi Shimizu

IPC: A61K9/00 ,  A61K47/48 ,  C07K1/113

CPC classification number: A61K9/0092 ,  A61K47/6925 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00 ,  C07K1/1136

Abstract: Provided is an organic nanotube having a hydrophobized inner surface, formed by molecules including an asymmetric bipolar lipid molecule represented by the following General Formula (1) and a derivative thereof represented by the following General Formula (2), wherein the organic nanotube has a hydrophilized outer surface and a hydrophobized inner surface of a hollow cylinder and is formed by binary self-assembly, the organic nanotube encapsulates a hydrophobic guest in the hollow cylinder, has a function of refolding a denatured protein, and has a function of sustainably-releasing a hydrophobic drug according to the change in hydrophobicity of the inner surface of the tube or external stimulus, In Formulas (1) and (2), wherein the same symbols have the same meanings, G is a 1-glucopyranosyl group or 2-glucopyranosyl group, and n is an integer of 12 to 22.Particularly, an asymmetric bipolar lipid molecule and an ester thereof respectively represented by general formulae (1) and (2) wherein n is an integer of 18 to 22, both of Z1 and Z2 are single bonds, Y is Gly, m(s) is the same or different integer of 3 to 6, X is OH, and R is a methoxy group, an ethoxy group, or a benzyloxy group are novel substances, and can form a carboxylic acid based asymmetric nanotube by single component self-assembly or binary self-assembly.

Abstract translation: 本发明提供一种具有疏水化内表面的有机纳米管，其由包含由以下通式（1）表示的不对称双相脂质分子及其通式（2）所示的衍生物的分子形成，其中有机纳米管具有亲水化 外表面和中空圆柱体的疏水化内表面，并且通过二元自组装形成，有机纳米管在中空圆柱体中包封疏水性客体，具有重折叠变性蛋白质的功能，并且具有可持续释放的功能 根据管内表面或外部刺激物的疏水性变化的疏水性药物，在式（1）和（2）中，其中相同的符号具有相同的含义，G是1-吡喃葡萄糖基或2-吡喃葡萄糖基 ，n为12〜22的整数。特别地，分别由通式（1）和（2）表示的不对称双相脂质分子及其酯 erein n为18〜22的整数，Z1和Z2均为单键，Y为Gly，m（s）为3〜6的相同或不同的整数，X为OH，R为甲氧基， 乙氧基或苄氧基是新物质，可以通过单组分自组装或二元自组装形成羧酸类不对称纳米管。