公开(公告)号：US20190112606A1

公开(公告)日：2019-04-18

申请号：US16227902

申请日：2018-12-20

申请人： NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION ,  DAIICHI SANKYO COMPANY, LIMITED

发明人： Ken ISHII ,  Kouji KOBIYAMA ,  Taiki AOSHI ,  Fumihiko TAKESHITA ,  Yuji KASUYA ,  Takako NIWA ,  Makoto KOIZUMI

IPC分类号： C12N15/117 ,  A61K31/7125 ,  C12N7/00 ,  A61K39/145 ,  A61K39/155 ,  A61K39/39 ,  A61K31/713 ,  C07H21/04 ,  A61K39/12 ,  C08B37/00

摘要： The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3′-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and β-1,3-glucan.

公开(公告)号：US20160208260A1

公开(公告)日：2016-07-21

申请号：US15022856

申请日：2014-09-19

申请人： NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEAL TH AND NUTRITION ,  DAIICHI SANKYO COMPANY, LIMITED

发明人： Ken ISHII ,  Kouji KOBIYAMA ,  Taiki AOSHI ,  Fumihiko TAKESHITA ,  Yuji KASUYA ,  Takako NIWA ,  Makoto KOIZUMI

IPC分类号： C12N15/117 ,  C08B37/00 ,  C12N7/00 ,  A61K39/145 ,  A61K39/155 ,  C07H21/04 ,  A61K39/39

CPC分类号： C12N15/117 ,  A61K31/7125 ,  A61K31/713 ,  A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/55561 ,  A61K2039/55583 ,  C07H21/04 ,  C08B37/0024 ,  C12N7/00 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2310/351 ,  C12N2310/3519 ,  C12N2320/31 ,  C12N2760/16134 ,  C12N2760/18534

摘要： The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3′-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and β-1,3-glucan.

摘要翻译： 本发明提供了含有人源化K型CpG寡脱氧核苷酸和聚脱氧腺苷酸的寡脱氧核苷酸，其中所述聚脱氧腺苷酸位于人源化K型CpG寡脱氧核苷酸的3'侧。 此外，本发明提供含有上述寡脱氧核苷酸和β-葡聚糖的复合物。