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    ARENAVIRUS GROWTH INHIBITOR COMPRISING POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE
    1.
    发明申请
    ARENAVIRUS GROWTH INHIBITOR COMPRISING POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE 有权

    公开(公告)号：US20210292321A1

    公开(公告)日：2021-09-23

    申请号：US17255566

    申请日：2019-06-29

    申请人： NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY ,  Shionogi & Co., Ltd.

    发明人： Akihiro ISHII ,  Akihiko SATO ,  Makoto KAWAI ,  Yoshiyuki TAODA

    IPC分类号： C07D471/04 ,  C07D471/14 ,  C07D498/14 ,  A61P31/14

    摘要： The present invention provides a compound having antiviral activity, especially having arenavirus proliferation inhibitory activity, and/or a medicament comprising the compound. More preferably, the present invention provides a compound having proliferation inhibitory activity on the Old World arenaviruses such as Luna virus, Lassa virus, and lymphocytic choriomeningitis virus and/or the New World arenaviruses such as Junin virus, and/or a medicament comprising the compound.
    An arenavirus proliferation inhibitor comprising a compound represented by Formula (I) or a prodrug thereof or a pharmaceutically acceptable salt thereof: (wherein R1 is carboxy, or the like; A3 is CR2 or N; R2 is a hydrogen atom, halogen, hydroxy, or the like; R3 is a hydrogen atom, hydroxy, carboxy, cyano, formyl, alkyl optionally substituted with Substituent group F, or the like; either A1 or A2 is CR6R6, and the other is NR7, or A1 is CR8R9, and A2 is CR10R11; and R5, R6, R7, R8, R9, R10, and R11 are each independently a hydrogen atom, carboxy, cyano, alkyl optionally substituted with Substituent group F, or the like).

    ARENAVIRUS GROWTH INHIBITOR COMPRISING POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE
    2.
    发明申请
    ARENAVIRUS GROWTH INHIBITOR COMPRISING POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE 有权

    公开(公告)号：US20230117695A1

    公开(公告)日：2023-04-20

    申请号：US17957103

    申请日：2022-09-30

    申请人： NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY ,  Shionogi & Co., Ltd.

    发明人： Akihiro ISHII ,  Akihiko SATO ,  Makoto KAWAI ,  Yoshiyuki TAODA

    IPC分类号： C07D471/04 ,  A61P31/14 ,  C07D471/14 ,  C07D498/14

    摘要： The present invention provides a compound having antiviral activity, especially having arenavirus proliferation inhibitory activity, and/or a medicament comprising the compound. More preferably, the present invention provides a compound having proliferation inhibitory activity on the Old World arenaviruses such as Luna virus, Lassa virus, and lymphocytic choriomeningitis virus and/or the New World arenaviruses such as Junin virus, and/or a medicament comprising the compound.
    An arenavirus proliferation inhibitor comprising a compound represented by Formula (I) or a prodrug thereof or a pharmaceutically acceptable salt thereof. (wherein R1 is carboxy, or the like: A3 is CR2 or N; R2 is a hydrogen atom, halogen, hydroxy, or the like: R3 is a hydrogen atom, hydroxy, carboxy, cyano, formyl, alkyl optionally substituted with Substituent group F, or the like; either A1 or A2 is CR5R6, and the other is NR7, or A1 is CR8R9, and A2 is CR10OR11; and R5, R6, R7, R8, R9, R10, and R11 are each independently a hydrogen atom, carboxy, cyano, alkyl optionally substituted with Substituent group F, or the like).

    PHARMACEUTICAL COMPOSITIONS CONTAINING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUG THEREOF
    3.
    发明申请
    PHARMACEUTICAL COMPOSITIONS CONTAINING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUG THEREOF 有权

    公开(公告)号：US20220281890A1

    公开(公告)日：2022-09-08

    申请号：US17689194

    申请日：2022-03-08

    申请人： Shionogi & Co., Ltd.

    发明人： Makoto KAWAI ,  Kenji TOMITA ,  Toshiyuki AKIYAMA ,  Azusa OKANO ,  Masayoshi MIYAGAWA

    IPC分类号： C07D498/14 ,  A61P43/00 ,  A61P31/12 ,  A61P31/16 ,  A61K31/5383

    摘要： The present invention provides a pharmaceutical composition containing the following compound having antiviral action: P is hydrogen or a group to form a prodrug; A1 is CR1AR1B, S or O; A2 is CR2AR2B, S or O; A3 is CR3AR3B, S or O; A4 is each independently CR4AR4B, S or O; the number of hetero atoms among atoms constituting the ring which consists of A1, A2, A3, A4, nitrogen atom adjacent to A1 and carbon atom adjacent to A4, is 1 or 2; R1A and R1B are each independently hydrogen, halogen, alkyl, or the like; R2A and R2B are each independently hydrogen, halogen, alkyl, or the like; R3A and R3B are each independently hydrogen, halogen, alkyl, or the like; R4A and R4B are each independently hydrogen, halogen, alkyl, or the like; R3A and R3B may be taken together with an adjacent carbon atom to form non-aromatic carbocycle or non-aromatic heterocycle; R1 is fluorine; m is any integer of 1 to 2; and n is any integer of 1 to 2.