公开(公告)号：US3639256A

公开(公告)日：1972-02-01

申请号：US3639256D

申请日：1970-05-27

Applicant: NCR CO

Inventor： HORGER GEORG

IPC: A61K9/50 ,  B01J13/10 ,  A61K9/04 ,  B01J13/02 ,  B44D1/02

CPC classification number: A61K9/50 ,  B01J13/10 ,  Y10T428/2984 ,  Y10T428/2987 ,  Y10T428/2989

Abstract: A process is disclosed for manufacturing capsules, en masse, by use of a liquid-liquid phase separation which includes certain inorganic material as complexing, phase-separation-inducing, polymer. The disclosed process is conducted in an aqueous capsule manufacturing vehicle and the material which emerges as a liquid phase is an aqueous solution of organic hydrophilic polymeric material and inorganic polymeric material complexed together. The liquid-liquid phase separation of this invention is the type generally named ''''complex'''' coacervation wherein the separated, emergent, liquid phase includes a major portion of both, the organic hydrophilic polymeric material and the phase-separationinducing material; in this invention, inorganic polyacid polymeric material. The organic polymeric material and the inorganic polymeric material are complexed together by virtue of opposite electrical charges, the complex is at least partially immiscible with the manufacturing vehicle, and the manufacturing vehicle contains only a minor amount of either polymeric material. Preferred materials for use in practicing the present invention include gelatin as the organic hydrophilic polymeric material and polymolybdates and polytungstates as the inorganic polymeric phase-separation-inducing material.

Abstract translation: 公开了一种通过使用包含某些无机材料作为络合，相分离诱导的聚合物的液相分离来大量制造胶囊的方法。 所公开的方法在水性胶囊制造载体中进行，并且作为液相出现的材料是有机亲水聚合物材料和无机聚合物材料的水溶液复合在一起。 本发明的液 - 液相分离是通常称为“复合”凝聚的类型，其中分离的，紧急的液相包括两者的主要部分，有机亲水聚合物材料和相分离诱导材料; 在本发明中，无机多酸聚合材料。 有机聚合物材料和无机聚合物材料由于相反的电荷而复合在一起，复合物至少部分地与制造车辆不混溶，并且制造车辆仅含有少量的聚合物材料。 用于实施本发明的优选材料包括作为有机亲水聚合物材料的明胶和作为无机聚合物相分离诱导材料的多钼酸盐和多钨酸盐。

公开(公告)号：US3697437A

公开(公告)日：1972-10-10

申请号：US3697437D

申请日：1970-05-27

Applicant: NCR CO

Inventor： FOGLE MARK V ,  HORGER GEORG

IPC: A61K9/50 ,  B01J13/10 ,  A61K9/04 ,  B01J13/02 ,  B44D1/02

CPC classification number: B01J13/10 ,  A61K9/50 ,  Y10T428/2984 ,  Y10T428/2987 ,  Y10T428/2989

Abstract: A PROCESS IS DISCLOSED FOR MANUFACTURING CAPSULES, EN MASSE, BY USE OF A LIQUID-LIQUID PHASE SEPARATION WHICH INCLUDES POLYPHOSPHATE INORGANIC MATERIAL AS A COMPLEXING, PHASE-SEPARATION-INDUCING, POLYMER. THE DISCLOSED PROCESS IS CONDUCTED IN AN AQUEOUS CAPSULE MANUFACTURING VEHICLE AND THE MATERIAL WHICH EMERGES AS A LIQUID PHASE IS AN AQUEOUS SOLUTION OF ORGANIC HYDROPHILIC POLYMERIC MATERIAL AND INORGANIC POLYPHOSPHATE MATERIAL. THE LIQUIDLIQUID PHASE SEPARATION OF THIS INVENTION IS THE TYPE GENERALLY NAMED "COMPLEX" COACERVATION WHEREIN THE SEPARATED, EMERGENT, LIQUID PHASE INCLUDES A MAJOR PORTION OF BOTH, THE ORGANIC HYDROPHILIC POLYMERIC MATERIAL AND THE PHASE-SEPARATION-INDUCING MATERIAL-IN THIS INVENTION, POLYPHOSPHATE POLYMERIC MATERIAL. THE ORGANIC POLYMERIC MATERIAL AND THE INORGANIC POLYMERIC MATERIAL ARE COMPLEXED TOGETHER BY VIRTUE OF OPPOSITE ELECTRICAL CHARGES, THE COMPLEX IS AT LEAST PARTIALLY IMMISCIBLE WITH THE MANUFACTURING VEHICLE, AND THE MANUFACTURING VEHICLE CONTAINS ONLY A MINOR AMOUNT OF EITHER POLYMERIC MATERIAL. PREFERRED MATERIALS FOR USE IN PRACTICING THE PRESENT INVENTION INCLUDE GELATIN AS THE ORGANIC HYDROPHILIC POLYMERIC MATERIAL AND POLYPHOSPHATES AS THE INORGANIC POLYMERIC PHASE-SEPARATION-INDUCING MATERIAL.

公开(公告)号：US3872024A

公开(公告)日：1975-03-18

申请号：US4111270

申请日：1970-05-27

Applicant: NCR CO

Inventor： HORGER GEORG

IPC: B01J13/08 ,  B01J13/02 ,  B44D1/02

CPC classification number: B01J13/08 ,  Y10T428/24942 ,  Y10T428/24967 ,  Y10T428/2984 ,  Y10T428/2989

Abstract: A process is disclosed for liquid-liquid phase separation utilizing certain inorganic polymeric materials as phaseseparation-inducing materials. The disclosed process is conducted in an aqueous liquid manufacturing vehicle and the material which emerges as a liquid phase is an aqueous solution comprising organic hydrophilic polymeric material. The liquid-liquid phase separation of this disclosure is of the type generally named ''''simple'''' coacervation wherein a major portion of the organic hydrophilic polymeric material is included in the separated, emergent, liquid phase and the phase-separation-inducing material is substantially evenly distributed, as to concentration, between the separated phase and the manufacturing vehicle. Preferred materials for use in practicing the present invention include gelatin as the organic hydrophilic polymeric material and polysilicates and polyphosphates as the inorganic polymeric phase-separation-inducing materials. The liquid-liquid phase separation of the present invention is useful for, among other things, manufacturing, en masse, minute capsules having the organic and inorganic hydrophilic polymeric material as capsule wall material.

Abstract translation: 公开了使用某些无机聚合物材料作为相分离诱导材料的液 - 液相分离的方法。 所公开的方法在水性液体制造载体中进行，并且作为液相出现的材料是包含有机亲水性聚合物材料的水溶液。 本公开的液 - 液相分离是通常称为“简单”凝聚的类型，其中主要部分的有机亲水聚合物材料包括在分离的，紧急的液相中，并且相分离诱导材料基本上均匀 分布在分离相和制造车辆之间的浓度。 用于实施本发明的优选材料包括作为有机亲水聚合物材料的明胶和作为无机聚合物相分离诱导材料的聚硅酸盐和多磷酸盐。

公开(公告)号：US3692690A

公开(公告)日：1972-09-19

申请号：US3692690D

申请日：1970-05-27

Applicant: NCR CO

Inventor： HORGER GEORG

IPC: A61K9/50 ,  B01J13/10 ,  A61K9/04 ,  B01J13/02 ,  B44D1/02

CPC classification number: B01J13/10 ,  A61K9/50 ,  Y10T428/2984 ,  Y10T428/2987 ,  Y10T428/2989

Abstract: A PROCESS IS DISCLOSED FOR MANUFACTURING CAPSULES, EN MASSE, BY USE OF A LIQUID-LIQUID PHASE SEPARATION WHICH INCLUDES POLYSILICATE INORGANIC MATERIAL AS A COMPLEXING, PHASE-SEPARATION-INDUCING, POLYMER. THE DISCLOSED PROCESS IN CONDUCTED IN AN AQUEOUS CAPSULE MANUFACTURING VEHICLE AND THE MATERIAL WHICH EMERGES AS A LIQUID PHASE IS AN AQUEOUS SOLUTION OF ORGANIC HYDROPHILIC POLYMERIC MATERIAL AND INORGANIC POLYSILICATE MATERIAL. THE LIQUID-LIQUID PHASE SEPARATION OF THIS INVENTION IS THE TYPE GENERALLY NAMED "COMPLEX" COACERVATION WHEREIN THE SEPARATED, EMERGENT, LIQUID PHASE INCLUDES A MAJOR PORTION OF BOTH, THE ORGANIC HYDROPHILIC POLYMERIC MATERIAL AND THE PHASESEPARATION-INDUCING MATERIAL;-IN THIS INVENTION POLYSILICATE POLYMERIC MATERIAL. THE ORGANIC POLYMERIC MATERIAL AND THE INORGANIC POLYMERIC MATERIAL ARE COMPLEXED TOGETHER BY VIRTUE OF OPPOSITE ELECTRICAL CHARGES, THE COMPLEX IS LEAST PARTIALLY IMMISCIBLE WITH THE MANUFACTURING VEHICLE, AND THE MANUFACTURING VEHICLE CONTAINS ONLY A MINOR AMOUNT OF EITHER POLYMERIC MATERIAL. PREFERRED MATERIALS FOR USE IN PRACTICING THE PRESENT INVENTION INCLUDE GELATIN AS THE ORGANIC HYDROPHILIC POLYMERIC MATERIAL AND POLYSILICATES AS THE INORGANIC POLYMERIC PHASE-SEPARATIONINDUCING MATERIAL.

公开(公告)号：US3585998A

公开(公告)日：1971-06-22

申请号：US3585998D

申请日：1968-03-29

Applicant: NCR CO

Inventor： HAYFORD DONALD E ,  HORGER GEORG

IPC: A61F13/511 ,  A61F13/15 ,  A61F13/49 ,  A61F13/16

CPC classification number: A61F13/8405

Abstract: This invention is directed to disposable baby diapers and baby diaper liners, viz., disposable baby diaper components containing encapsulated baby oil.